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All Journal International Journal of Advanced Health Science and Technology Jurnal Info Kesehatan
Salleh, Mohd Nazil
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Electrical & Electronics Engineering Health Professions Immunology & microbiology Nursing Public Health

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Enhancing the Therapeutic Potential of Purslane Leaf Extract (Portulaca oleracea) for Cholesterol Management Christyaningsih, Juliana; Izza, Fahin; Raiza, Regina; Nayla, Azfa Alifatun; Pristanti, Deswita Aulia; Az-Zahra, Faradyna Putri; Salleh, Mohd Nazil
International Journal of Advanced Health Science and Technology Vol. 4 No. 5 (2024): October
Publisher : Forum Ilmiah Teknologi dan Ilmu Kesehatan (FORITIKES)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/ijahst.v4i5.418

Abstract

Cholesterol is one of the essential molecules in humans. An imbalance in cholesterol levels in the body, such as high levels of triglycerides and low-density lipoprotein (LDL) or total cholesterol, can contribute to one of the leading causes of death in Indonesia. Diseases caused by high cholesterol levels include cardiovascular diseases, atherosclerosis, hypercholesterolemia, hyperlipidemia, coronary heart disease, hypertension, and stroke [6,9,14]. As a result, additional intake from sources like omega-3-rich supplements or herbal remedies is recommended. Historically, plant-based treatments have been used as pharmacological therapies. Researchers have explored the use of purslane (Portulaca oleracea) leaves, which contain unsaturated fatty acids and antioxidants, including omega-3 fatty acids, vitamins A and C, and minerals such as magnesium and potassium, offering cardiovascular benefits. The researchers utilized purslane extract as an herbal tea blend, serving as a natural alternative to supplements in capsule form, which may be more expensive. In extract form, purslane leaves are hygienically processed and mixed with herbal tea, creating a convenient health drink for daily consumption. The purslane leaf extract was obtained through method maceration using 96% food-grade ethanol. Proximate tests were conducted to assess total energy, energy from fat, ash content, moisture content, carbohydrates (by difference), total fat, and protein content [5,24]. Sensory evaluation was conducted by semi-trained panelists to assess the color, aroma, and taste of herbal tea blends containing purslane leaf extract. This evaluation aimed to collect subjective feedback from potential consumers regarding the organoleptic characteristics of the product.
Treatment Duration and Its Impact on the Number of Polymorphonuclear, Mononuclear and Neutrophil Lymphocyte Ratio as Indicators of Recovery Rate in Tuberculosis Patients Aini, Aini; Fihiruddin, Fihiruddin; Diarti, Maruni Wiwin; Tatontos, Erlin Yustin; Salleh, Mohd Nazil
JURNAL INFO KESEHATAN Vol 23 No 4 (2025): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol23.Iss4.1960

Abstract

The calculation of leukocyte types can be used to assess the level of infection or inflammation, particularly through the neutrophil-lymphocyte ratio (NLR). The NLR has been established as a useful biomarker for predicting bacteremia. Although differential leukocyte count and the neutrophil–lymphocyte ratio (NLR) have been widely proposed as indicators of infection and inflammation, their clinical interpretation remains unclear across disease states, particularly in tuberculosis. Current evidence is limited regarding how leukocyte profiles and NLR change during standard anti tuberculosis treatment (ATT), especially in the early and intermediate phases of therapy. Furthermore, it is not well established whether changes in leukocyte subtypes reflect treatment response or disease recovery in tuberculosis patients. Therefore, there is a need to quantify changes in leukocytes and NLR during TB treatment and to determine their potential role as readily accessible biomarkers for monitoring therapy outcomes. The goal of this study was to determine the effect of treatment duration on the number of polymorphonuclear cells, mononuclear cells, and the neutrophil-lymphocyte ratio as indicators of recovery in TB patients. This study employed a cross-sectional design with an analytical observational approach, involving 26 TB patients undergoing treatment for 1 to 6 months. The results showed the following average cell counts (per microliter) over the treatment period: basophils at 0.04, eosinophils at 0.30, neutrophils at 4.10, lymphocytes at 2.36, monocytes at 1.84, and a neutrophil-lymphocyte ratio of 0.53. One-way ANOVA analysis revealed a positive correlation between basophils, neutrophils, lymphocytes, monocytes, and the neutrophil-lymphocyte ratio with TB recovery. In conclusion, treatment of TB patients during the fourth to sixth month, or in the advanced phase of treatment showed differences in the number of  polymorphonuclear cells, mononuclear cells and  the NLR ratio compared to intensive phase treatment in TB patients at the Karang Taliwang and akranegara Health Centers.
Co-Authors Aini, Aini Az-Zahra, Faradyna Putri Erlin Yustin Tatontos Fihiruddin, Fihiruddin Izza, Fahin Juliana Christyaningsih Maruni Wiwin Diarti Nayla, Azfa Alifatun Pristanti, Deswita Aulia Raiza, Regina