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Efek Glycine max Varietas Anjasmoro terhadap Kadar Timbal dan Malondialdehid pada Mencit Terintoksikasi Timbal Yulia, Rika; Karina, Lidya; Veronica, .; Christyaningsih, Juliana
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 1 (2014)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (473.933 KB)

Abstract

The objective of this research is investigating the effect of Glycine max Anjasmoro variety to mice with lead intoxication by measuring the levels of Pb in mice's (Mus musculus) blood and MDA in mice's liver and kidney strain BALB/C by using the thiobarbituric acid reactive substance (TBARS) assay. Research carried out by using 20 mice strain BALB/C that were randomly divided into four groups of five mice including negative control, positive control, treatment, and reference. All groups except positive control were intoxicated with lead in a dose of 25 mg/kg body weight for the duration of seven days. One gram of Glycine max has been given to the treatment group and positive control. There after 64 mg/kg body weight of vitamin has been given to the reference group. The results showed that Glycine max Anjasmoro varieties was significantly decrease the levels of lead in mice's blood and also reduce the levels of MDA in the liver and kidney although the results were not significant.Keywords : Glycine max Anjasmoro variety, lead, malondialdehyde, vitamin C, Mus musculus
Efek Glycine max Varietas Anjasmoro terhadap Kadar Timbal dan Malondialdehid pada Mencit Terintoksikasi Timbal Yulia, Rika; Karina, Lidya; Veronica, .; Christyaningsih, Juliana
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (473.933 KB) | DOI: 10.35617/jfi.v7i1.153

Abstract

The objective of this research is investigating the effect of Glycine max Anjasmoro variety to mice with lead intoxication by measuring the levels of Pb in mice's (Mus musculus) blood and MDA in mice's liver and kidney strain BALB/C by using the thiobarbituric acid reactive substance (TBARS) assay. Research carried out by using 20 mice strain BALB/C that were randomly divided into four groups of five mice including negative control, positive control, treatment, and reference. All groups except positive control were intoxicated with lead in a dose of 25 mg/kg body weight for the duration of seven days. One gram of Glycine max has been given to the treatment group and positive control. There after 64 mg/kg body weight of vitamin has been given to the reference group. The results showed that Glycine max Anjasmoro varieties was significantly decrease the levels of lead in mice's blood and also reduce the levels of MDA in the liver and kidney although the results were not significant.Keywords : Glycine max Anjasmoro variety, lead, malondialdehyde, vitamin C, Mus musculus
PENGARUH SUBSTITUSI TEPUNG IKAN LELE TERHADAP PEMBUATAN COOKIES BEBAS GLUTEN DAN KASEIN SEBAGAI ALTERNATIF JAJANAN ANAK AUTISM SPECTRUM DISORDER [Effect of Catfish Flour Substitution towards Gluten-Free and Casein-Free Cookies as an Alternative Snack for Children with Autism Spectrum Disorder] Aliffah Nurria Nastiti; Juliana Christyaningsih
Media Gizi Indonesia Vol. 14 No. 1 (2019): JURNAL MEDIA GIZI INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (380.492 KB) | DOI: 10.20473/mgi.v14i1.35-43

Abstract

Children with Autism Spectrum Disorder (ASD) have digestive disorders, therefore their diet should be gluten-free and casein-free. Gluten-free and casein-free foods tend to be low in protein. ASD children who apply a gluten-free diet and casein have a lower calcium intake and low in bone density. Catfish flour with high protein and calcium content were expected to increase the nutritional value (protein and calcium) of cookies which gluten-free and casein-free. This study was aimed to determine the effect of catfish flour substitution towards acceptance and nutritional value of gluten and casein free cookies as an alternative snack for ASD children. This study was experimental research with Completely Randomized Design. Panelists of this study were children with ASD (4-6 years) and their parents as many as 40 people. There were 4 formulas in this study, F0 was control, and 3 substitution formulas. Percentage of Flour substitution were, F2 (2%: 2%); F3 (4%: 4%); and F5 (6%: 4%). Kruskal Wallis test showed no significant difference in the level on acceptance level in taste and aroma between F0, F3, and F5. The acceptability and nutritional value's ranking showed the best formula was F5. 100 grams of F5 cookies (protein: 6.75 g; calcium: 247.51 mg) can fulfill 19% of the protein and 24.8% calcium of children RDA (4-6 years). Gluten-free and casein-free cookies with catfish (Formula 5) with enough protein and high calcium can be an alternative snack for ASD children.
PENGARUH ASAM ASKORBAT TERHADAP KADAR TIMBAL FETUS DAN AKTIVITAS ENZIM SITOKROM P450 1A1 (CYP1A1) PADA INDUK MENCIT TERINTOKSIKASI TIMBAL Juliana Christyaningsih; Harianto Notopuro; Win Darmanto; Diah Titik Mutiarawati
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 16 No 1 (2010): December 2010
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/280

Abstract

Lead contamination occurs through air pollution and industry, enter the body through respiratory and digestive tract. High lead content will accumulate and affect adversely the cognitive function, causing neuropsychological dysfunction, encephalopathy, hyperactivity and other problems in children, disrupt the central nervous system and the immune system of children as well. This experimental research was randomized control group post-test only design. The experiment used of 27 pregnant mice, divided into three groups: negative control group, which were given distilled water, positive control group were exposed only to lead and the third group were exposed to lead and administered ascorbic acid. 25 mg/kg/day/orally neutral lead acetate was given during gestation day 7 to 16, and ascorbic acid 64 mg/kg/day/orally, started on gestation day 9 to 16. Treatment group with ascorbic acid supplementation had the lowest CYP1A1 enzyme activity compared to positive and negative control groups. This results confirmed by the molecular weight of CYP1A1 enzyme ranges 53.7 to 59.2 kDa, and the western blotting test showed the same thin band both two groups. The lowest of the average lead concentration in the head of fetal mice was found on the group of mice that treated with vitamin C. Supplementation of ascorbic acid can protect the liver and fetuses, by suspected mechanism that ascorbic acid could chelate the lead and excrete it via urine.
UJI STABILITAS POOLED SERA YANG DISIMPAN DALAM FREEZER UNTUK PEMANTAPAN MUTU INTERNAL DI LABORATORIUM KLINIK Anik Handayati; Juliana Christyaningsih; Tjipto Rini
JURNAL PENELITIAN KESEHATAN Vol 12, No 1 (2014): Jurnal Penelitian Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.559 KB)

Abstract

Stability of control sera is very important in order to assess the performance of a laboratory, including quality instruments and reagents. Some small laboratories are using pooled sera as a control sera for day-to- day examination. In general, the temperature of the freezer is used to save serum in - 7 to - 4the freezer is frequently opened  and closed so it is likely the temperature is too unstable. This study was an experiment laboratory, with  the time series control group design. The serum was analyzed the influence of storage time in the freezer at a temperature of -7 to -4ºC and a temperature of – 15stability of the normal and abnormal of pooled sera and examination were using the parameters of glucose, cholesterol and uric acid in serum. Samples were divided into 9 groups: 0,  1, 2 , 3 , 4 , 5, 6, 7 , 8 weeks. Data were analyzed with regression equations. The storage effect on normal and abnormal of blood glucose level in the freezer temperature -7 º to -4 º C for 8 weeks but at - 15temperature had no effect on both normal and abnormal of serum glucose level. There was no effect of storage in a freezer temperature -7 º to -4 º C and -15 º C for 8 weeks on cholesterol levels and normal and abnormal uric acid. Key Word: stability, control of sera, freezer, internal quality, clinical laboratory
Assistance in improving the welfare of foster grandmothers at the Tikung Health Center, Lamongan Regency Lieliek Soetjiatie; Juliana Christyaningsih; Nur Hatijah
Community Empowerment Vol 7 No 2 (2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (373.897 KB) | DOI: 10.31603/ce.5975

Abstract

This community service intends to assist Tikung Health Center foster grandmothers in becoming great grandmothers with healthy toddlers. Because the toddler's mother was at work, the foster grandmother program began with the Posyandu Toddler activity, which was attended by grandmothers taking their grandchildren. As a result, support is still required to improve grandmothers' and grandchildren's nutrition and health awareness. Nutrition education for the elderly, parenting and nutrition education for toddlers, nutrition counseling services and blood glucose checks, and community empowerment through cassava processing competitions (local foods) are all part of this program. The program went off without a hitch, thanks to the foster grandmothers' joyful reception and a lot of help from cadres, PKK, village officials, and the Tikung Health Center in Lamongan Regency. Foster grandmothers' knowledge of parenting and nutrition is also increased, as is their ability to process many varieties of processed cassava, which can provide income opportunities for foster grandmothers and their family.
The Effectiveness Of Moringa Leaf Extract (Moringa oleifera) on Cadmium and LDL Cholesterol Levels in Blood as Indicators of Atherosclerosis in Cadmium (Cd) Induced White Rats (Rattus norvegicus) Vernanda Arsya Nabilla; Indah Lestari; Christ Kartika Rahayuningsih; Juliana Christyaningsih
Jurnal Teknokes Vol 15 No 3 (2022): September
Publisher : Jurusan Teknik Elektromedik, POLTEKKES KEMENKES Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/teknokes.v15i3.268

Abstract

Moringa leaves (Moringa oleifera) have chelating agent properties that act as natural antioxidants in binding heavy metals and free radical scavengers, with cadmium being one of the heavy metals free radicals having toxic effects on the body. Exposure to cadmium can reduce the activity of lipoprotein lipase enzymes (LPL) which function in the triglycerides and free fatty acids catabolism process, and can increase cholesterol and triglyceride levels in the blood. This study aims to determine the effectiveness of Moringa (Moringa oleifera) on Cadmium chloride-induced white rats (Rattus norvegicus) using an experimental research design with a quantitative analysis technique. This study uses the level of cadmium and LDL cholesterol for the dependent variable and the dose of Moringa leaf extract (Moringa oleifera) for its independent variable. The samples used are white rats (Rattus norvegicus) aged 8-12 weeks with a weight of 150-200 grams, along with blood drawn from the heart for the specimen. The researcher conducted the study at the Faculty of Veterinary Medicine, Airlangga University; Surabaya Health Laboratory Center; and Surabaya Bakti Analysis Laboratory from October 2021 to June 2022 using Atomic Absorption Spectrophotometry (AAS) and Chemical Analyzer BS-200. The results show that the average value of cadmium and LDL cholesterol levels in white rats in treatment group 1 are 0.605 g/dL and 8.25 mg/dL, group 2 are 0.075 g/dL & 18.5 mg/dL; and group 3 are 0.08125 g/dL and 12 mg/dL. Based on the statistical analysis of the One-Way ANOVA test, the sig. p-value is > 0.05. Thus, the average value of cadmium and LDL cholesterol has no significant difference. Compared to the 400 mg/kgBW and 500 mg/kgBW, the 600 mg/kgBW dose has the best effectiveness in reducing LDL cholesterol in white rats (Rattus norvegicus) after being induced with cadmium chloride. This study recommends consuming fresh Moringa leaves (Moringa oleifera) as much as 66.522 grams per human/day as an additional antioxidant and chelating agent.
The Effectiveness of Moringa Oleifera Leaf Extract on Hepatotoxic Case Reviewing from Cadmium, SGOT and SGPT Blood Levels in white Rats (Rattus norvegicus) Induced with Cadmium (Cd) Devi Puspitasari; Indah Lestari; Christ Kartika Rahayuningsih; Juliana Christyaningsih
Jurnal Teknokes Vol 15 No 3 (2022): September
Publisher : Jurusan Teknik Elektromedik, POLTEKKES KEMENKES Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/teknokes.v15i3.278

Abstract

Moringa leaf (Moringa oleifera Lamk.) is part of herbal plants that have been known for their good natural chelating agent and hepatoprotective properties, especially in hepatotoxic events due to cadmium (Cd) exposure, where flavonoid compounds are contained in the form of quercetin and kaempferol, vitamin A, vitamin C and several phenol components that can inhibit the accumulation of cadmium metals and neutralize free radicals by lowering SGOT and SGPT levels, so this study aimed to determine the effectiveness of moringa leaf extract (Moringa oleifera Lamk.) against hepatotoxic in white rats (Rattus norvegicus) induced with cadmium. This study was expected to provide potential of Moringa leaves in hepatotoxic case at dose 400 mg/kgwb, 500 mg/kgwb and 600 mg/kgwb in white rats. This research was an experimental study with quantitative analysis conducted at the Faculty of Veterinary Medicine, Airlangga University, Surabaya Health Laboratory Center, and Bakti Analisa Laboratory in November 2021 – July 2022. The independent variable was the dose of Moringa leaf extract and the dependent variables were levels of cadmium, SGOT and SGPT in white rat blood. Analysis of blood cadmium levels using an atomic absorption spectrophotometer and analysis of SGOT SGPT levels using the BS-200 Chemistry Analyzer. The results showed that the average blood cadmium, SGOT and SGPT levels in treatment group 1 were 0.0605 μg/dL, 260.175 U/L, and 143.85 U/L; in treatment group 2 were 0.075 μg/dL, 250.925 U/L and 77.575 U/L; in treatment group 3 were 0.08125 μg/dL, 171.475 U/L and 66.075 U/L. Based on statistical analysis of One-way Anova test, sig. p value > 0.05, there was no significant difference in cadmium and SGOT levels. Then, the results of the Kruskal wallis test on SGPT levels showed sig. p value > 0.05, there was no significant difference in all treatments. Moringa leaf extract at a dose of 600 mg/kgbw/day had the best effect as chelating agent and hepatoprotective compared to doses of 400 mg/kgbw/day and 500 mg/kgbw/day at cadmium induction for 10 days. From this study, we recommend to consume about 66,522 g/day Moringa fresh leaves as the natural chelating agent and hepatoprotector for overcoming acute hepatotoxic case. INDEX TERMS Moringa Leaves, Cadmium, SGOT, SGPT, Rattus norvegicus, Atomic Absorption Spectrophotometer, Chemistry Analyzer
Comparison of Acceptability Test of Alternative Diabetic Snacks Obtain from Fiber and Protein Levels Pineapple Moringa Velva with Addition of Oatmeal Rihlah Sa'idah; Juliana Christyaningsih; Melina Sari; Patcharanee Pavadhgul
International Journal of Advanced Health Science and Technology Vol. 2 No. 6 (2022): December
Publisher : Forum Ilmiah Teknologi dan Ilmu Kesehatan (FORITIKES)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/ijahst.v2i6.179

Abstract

Diabetes is a major public health problem. For diabetics, diet shows great potential in controlling blood glucose levels by practicing regular eating patterns, either snacking between meals. Then, it’s important to consume foods with a low glycemic index, meanwhile fulfill daily protein and fiber intake. This study aims to identify organoleptic tests, along with analysis of fiber and protein levels from the best organoleptic test results. This type of research was a pre-experimental design on 3 groups velva. Organoleptic tests were performed on 25 trained panelists using purposive sampling. Analysis technique uses kruskall wallis and mann whitney test. Also, laboratory tests for fiber and protein levels. The results of this study are diabetics have a daily calorie requirement of 1,500 kcal. Moreover, 150 kcal is required for one snack, 7.5 g of protein and 2.5 g for fiber is needed. In addition, based on the results of the organoleptic test, the best velva is formulation 3 (KN 03). The average value obtained from 25 panelists is 3.38. The fiber content contained in the formulation 3 velva is 3.19 g/100 g. Meanwhile, the protein content per 100 g is 8.68 g. The conclusion of this study is that diabetics can consume velva at a rate of 1 cup (100 g) with 151.9 kcal calories per snack consumption to meet 10% of their daily fiber and protein needs. The implication of this research is to find the best velva formulation with high fiber and protein levels for diabetics
Nutrition education through provision of additional local food for pregnant women and toddlers in Kalisat District, Jember Regency Erlyna Jayeng Wijayanti; Juliana Christyaningsih; Umul Annisa Fadhila; Ainur Rifda Kurnia Puspita Sari
Community Empowerment Vol 7 No 9 (2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.6480

Abstract

The Nahdlatul Ulama Health Institute (LKNU), Puskesmas in the Jember Region and Poltekkes Kemenkes Surabaya held community service activities aimed at reducing the prevalence of stunting under five. The activity began with family assistance for pregnant women and stunting toddlers, which were attended by 112 mothers of toddlers and 40 pregnant women, and continued with nutrition education conducted by nutrition counseling with media in the form of posters, flipcharts and games. The third is the provision of nutritional intake for pregnant women and toddlers through Supplementary Food Provision (PMT), and the last is demonstration of examples of balanced nutrition for toddlers according to the principle of balanced nutrition through the use of local food ingredients. The results of the activity revealed an increase in the knowledge of pregnant women and mothers of toddlers by 47%, an increase in the attitudes of pregnant women by 4% and mothers of toddlers by 1.9%, as well as an increase in the practice behavior of pregnant women and mothers of toddlers in preparing and providing a balanced nutritional menu of local food.
Co-Authors ., Pestariati Adistya Dwi Cantika Ahmad Yudianto Ainur Rifda Kurnia Puspita Sari Ainur Wachidah Choirun Niza Aisya Eliarosa Andriyani, Nurul Ani Intiyati Ani Media Harumi Ani Media Harumi Anita Dwi Anggraini Annas Buanasita Astuti Setiyani Astuti Setiyani Ayu Puspitasari, Ayu Ayunis Naba'ur Rhodiyah Az-Zahra, Faradyna Putri Bambang Hadi Sugito Christ Kartika Rahayuningsih Darjati Deddy Adam Dedi Kurniawan Demes Nurmayanti Devi Eka Ratnasari Devi Puspitasari Dewi, Amiliya Antika Diah Titik Mutiarawati Dian Shofiya Dwi Purwanti Dyah Purbosari Dwi Pitaloka Edy Haryanto Endarini, Lully Hani Endarini, Lully Hanni Endro Yulianto Ervi Husni, Ervi Evi Yunita N Evi Yunita Nugrahini Evy Diah Woelansari Ferry Kriswandana Fika Nur Septianingtias Filisia Luna Andyana Firda Amalia Pratiwi Ginarsih, Yuni Hadi Suryono Halimah, Husnul Handayati, Anik HANIFA RAHMAWATI Harianto Notopuro Hermiyanti, Pratiwi Hilmi Yumni Hindaryani, Nurul Husnul Halimah I Dewa Gede Hari Wisana Ida Ariyanti, Ida Imam Sarwo Indah Lestari Indah Lestari Indah Lestari, Indah Inne Soesanti Ira Puspita Sari Ira Puspitasari Ira Puspitasari Ira Rahayu Tiyar Irwan Sulistio Isfentiani, Dina Islaha, Maria Isnanto Istanto, Wisnu Izza, Fahin Jayeng Wijayanti, Erlyna Karina, Lidya Karina, Lidya Kasiati Khambali, Khambali Khristine Saputri Kiaonarn Ongko Waluyo Kiaonarni O.W Kiaonarni OW Laili Rahmawati, Laili Lembunai Tat Alberta Lembunai Tat Alberta, Lembunai Tat Lieliek Soetjiatie Liliek Soetjiatie Liliek Soetjiatie Lully Hani Endarini Lully Hani Endarini Luthfi Rusyadi Mamik Mamik Mamik Mamik Marina Pengge Maulidyah Aisyah Putri Nadifah Meidayana, Ema Meisya Argia Sisviani Deva Melania Rizerda Pebianti Melina Sari MINARTI Minarti Minarti Minarti Minarti Mujayanto Mujayanto Muna Setia Madihah Museyaroh, Museyaroh Mutiarawati, Diah Titik N. S. Widodo Nadia Salsabila Nastiti, Aliffah Nurria Nayla, Azfa Alifatun Nugroho, Riezky Faisal Nuning Nuning Marina Pengge Nur Hatijah Nur Hatijah Nur Hatijah Nur Kholifah, Siti Nurul Hindaryani Nurul Hindaryani Nurwening TW Nuswantari, Atika Oktavianingsih, Yulis Patcharanee Pavadhgul Pebianti, Melania Rizerda Pengge, Nuning Marina Pojor Srirejeki Eka Lestari Pristanti, Deswita Aulia Purwanti, Dwi Puspita Zella Wigati Puspitadewi, Teresia Retna Queen Khoirun Nisa' Mairo Rahayu Sumaningsih Rahayuningsih, Christ Kartika Raiza, Regina Ratna Sari Ratno Tri Utomo Retno Puspitadewi, Teresia Retno Sasongko Wati Retno Sasongkowati Retno Sasongkowati Rihlah Sa'idah Rika Yulia Rokhmalia, Fitri Salleh, Mohd Nazil Sari, Ira Rahayu Tiyar Sasongkowati, Retno Sherly Amri, Qonita Salsabilla Amara sherly jeniawaty Sherly Jeniawaty Sholikah, Mar'atus Siagian, Hotmaida Siti Alfiah Siti Mar'atus Slamet Wardoyo Sri Sulami Endah Astuti Sri Utami SRI UTAMI Suhariyadi Suhariyadi Suhariyadi Suhariyadi Suliati Suliati Suliati Suliati Suliati Sulistyowati, Dwi Wahyu Wulan Sumasto, Hery Supriyatin, Endah Suyanto, Beny Tatarini Pipit Ika Cahyani Taufiqurrahman Taufiqurrahman Teresia Retna Teta Puji Rahayu Tjipto Rini Toni Watoyani ulfa hidayah Umul Annisa Fadhila Utomo, Ratno Tri Vernanda Arsya Nabilla Veronica, . Veronica, . Win Darmanto Wisnu Istanto Wulandari, Meisa Yohanes Kambaru W Yusianti Silviani Zida Shabrina Akmalia