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All Journal Indonesian Journal of Dental Medicine
Rachmad C, Alfin
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Dentistry

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MicroRNA-21 expression as a novel diagnostic and prognostic biomarker in oral cancer: A narrative review Llahfi, Yasminia Sambac Shofie Putri; Zafar, Anis Fatimah; ZV, Astrid Faradia; Pandora, Imelda Prisca; SD, Alfonsus Sindhu; NA, Muhammad Rafi; Widyanti, Salma Putri; Andrew, Emmanuel; Eliya A, Salsabilla; Alfisaida, Aliyya; Qadira R, Malika; Rodhiyah B, Aimmatur; Ramadhani, Puspita; Indriani, Ratri; Salim, Achmad Faishal; Septyan A, Ciptantyo; Rachmad C, Alfin; Mujahidah, Amirah; Wati, Sisca Meida
Indonesian Journal of Dental Medicine Vol. 7 No. 2 (2024): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v7i2.2024.73-76

Abstract

Background: Oral cancer is a life-threatening disease that has 377.713 new cases every year and 60% of the 5-year overall survival rate globally. Approximately 84–97% of oral cancer arises from squamous cells, categorized as oral squamous cell carcinoma (OSCC). MiR-21 is a single-stranded, non-coding RNA that has been studied for its role in carcinogenesis. Overexpression of miR-21 is found in various cancers and is linked to a poor prognosis. However, few studies analyze the expression of miR-21 as a diagnostic and prognostic biomarker in oral cancer. Purpose: This review aimed to describe the expression of miR-21 as a novel diagnostic and prognostic biomarker in oral cancer. Review: MiR-21 was found to be upregulated in various cancers, including oral cancer. miR-21 targets several tumor suppressors such as PTEM, TPM1, and PDCD4 to modulate characteristics linked to cancer prognosis, including cell proliferation, apoptosis, invasion, and metastasis. Furthermore, the constant increase of miR-21 expression in healthy oral mucosa to oral potentially malignant disease to OSCC demonstrated its diagnostic value. Conclusion: miRNA-21 may act as a novel diagnostic and prognosticbiomarker of oral cancer.
Co-Authors Alfisaida, Aliyya Andrew, Emmanuel Eliya A, Salsabilla Indriani, Ratri Llahfi, Yasminia Sambac Shofie Putri Mujahidah, Amirah NA, Muhammad Rafi Pandora, Imelda Prisca Qadira R, Malika Ramadhani, Puspita Rodhiyah B, Aimmatur Salim, Achmad Faishal SD, Alfonsus Sindhu Septyan A, Ciptantyo Sisca Meida Wati Widyanti, Salma Putri Zafar, Anis Fatimah ZV, Astrid Faradia