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All Journal Indonesian Journal of Dental Medicine Bhakta Dental Journal
Zafar, Anis Fatimah
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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MicroRNA-21 expression as a novel diagnostic and prognostic biomarker in oral cancer: A narrative review Llahfi, Yasminia Sambac Shofie Putri; Zafar, Anis Fatimah; ZV, Astrid Faradia; Pandora, Imelda Prisca; SD, Alfonsus Sindhu; NA, Muhammad Rafi; Widyanti, Salma Putri; Andrew, Emmanuel; Eliya A, Salsabilla; Alfisaida, Aliyya; Qadira R, Malika; Rodhiyah B, Aimmatur; Ramadhani, Puspita; Indriani, Ratri; Salim, Achmad Faishal; Septyan A, Ciptantyo; Rachmad C, Alfin; Mujahidah, Amirah; Wati, Sisca Meida
Indonesian Journal of Dental Medicine Vol. 7 No. 2 (2024): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v7i2.2024.73-76

Abstract

Background: Oral cancer is a life-threatening disease that has 377.713 new cases every year and 60% of the 5-year overall survival rate globally. Approximately 84–97% of oral cancer arises from squamous cells, categorized as oral squamous cell carcinoma (OSCC). MiR-21 is a single-stranded, non-coding RNA that has been studied for its role in carcinogenesis. Overexpression of miR-21 is found in various cancers and is linked to a poor prognosis. However, few studies analyze the expression of miR-21 as a diagnostic and prognostic biomarker in oral cancer. Purpose: This review aimed to describe the expression of miR-21 as a novel diagnostic and prognostic biomarker in oral cancer. Review: MiR-21 was found to be upregulated in various cancers, including oral cancer. miR-21 targets several tumor suppressors such as PTEM, TPM1, and PDCD4 to modulate characteristics linked to cancer prognosis, including cell proliferation, apoptosis, invasion, and metastasis. Furthermore, the constant increase of miR-21 expression in healthy oral mucosa to oral potentially malignant disease to OSCC demonstrated its diagnostic value. Conclusion: miRNA-21 may act as a novel diagnostic and prognosticbiomarker of oral cancer.
Mdm2 Gene as Transcriptional Protein Antagonist of P53 in OSCC with Mir-218 Expression Hanif, Hilmy Irsyadi; Zafar, Anis Fatimah; Puteri, Astari; Wati, Sisca Meida; Rahayu, Retno Pudji
Bhakta Dental Journal Vol 2 No 02 (2024): Desember
Publisher : Fakultas Kedokteran Gigi IIK Bhakti Wiyata, Kediri.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/bhaktadent.v2i02.47

Abstract

Background: Murine double minute-2 (Mdm-2) gene expressed overly to the various type of human cancers. Murine double minute-2 associates with p53 affecting negatively with its gene products for activation of its transcriptional function. These genes mainly expressed in oral squamous cell carcinomas with p53 mutation condition. MicroRNAs nowadays becoming a promising diagnostic and prognostic biomarkers for malignancy through the expression and regulating the transcriptional function. It is reported that mir-218 expression may indicate the occurrence of OSCC. Purpose: The literature describes the putative pathway and function of mdm2 gene as transcriptional antagonist function of p53 in OSCC of mir-218 expression. Review(s): The relationship of mdm2 with mir-218 expression in OSCC may indicate the alternative mechanism of p53 dysfunction condition. Downregulated mir-218 will tend less binding to promoter of p53 causing the mutant state. The overexpression of mdm-2 may constitute inactivation of p53. Conclusion: The study findings may suggest mdm2 protein causing in OSCC due alternative mechanism of p53 as downregulated expression of mir-218.
Co-Authors Alfisaida, Aliyya Andrew, Emmanuel Eliya A, Salsabilla Hanif, Hilmy Irsyadi Indriani, Ratri Llahfi, Yasminia Sambac Shofie Putri Mujahidah, Amirah NA, Muhammad Rafi Pandora, Imelda Prisca Puteri, Astari Qadira R, Malika Rachmad C, Alfin Ramadhani, Puspita Retno Pudji Rahayu Rodhiyah B, Aimmatur Salim, Achmad Faishal SD, Alfonsus Sindhu Septyan A, Ciptantyo Sisca Meida Wati Widyanti, Salma Putri ZV, Astrid Faradia