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All Journal Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Indonesian Journal of Dental Medicine Bhakta Dental Journal Frontiers on Healthcare Research
Sisca Meida Wati
Department Of Oral Pathology And Maxillofacial, Faculty Of Dental Medicine, Universitas Airlangga
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Characterization of lactoferrin in gingival crevicular fluid of chronic periodontitis patient Sisca Meida Wati; Istiati Istiati; Pratiwi Soesilawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 47 No. 3 (2014): September 2014
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.745 KB) | DOI: 10.20473/j.djmkg.v47.i3.p141-145

Abstract

Background: Human periodontal diseases are inflammatory disorders as the result of complex interactions between periodontopathogens and the host’s immune response. Periodontitis results in tooth loss and can even lead to systemic diseases if not treated. Gingival crevicular fluid (GCF) reflects the condition of the gingiva and contains proteins transuded from serum or cells at inflamated sites. Polymorphonuclear leukocyte (PMNs) infiltration can be seen in each stage of periodontitis. Lactoferrin is one of the PMN specific granules and could be a useful marker of PMN activity. Purpose: The aim of this study was to determine the band intensity of lactoferrin used as periodontitis biomarker. Methods: Gingival crevicular fluid (GCF) samples were collected using paper point no.30 from 40 subjects, 30 periodontitis patients that devide according to the severity (10 mild periodontitis, 10 moderate periodontitis, and 10 severe periodontitis) and 10 healthy controls, ranging in ages from 20 to 35 years. GCF lactoferrin was analyzed by Western blot and measured the band intensity by quantity one software (bio-rad). Results: The periodontitis sites exhibited significantly greater band intensity of lactoferrin than healthy sites. The band intensity of lactoferrin was positively correlated with the severity of periodontitis (α = 0.05). Conclusion: The study showed that the intensity of the lactoferrin protein bands could be used as biomarkers of periodontitis.Latar belakang: Penyakit periodontal adalah gangguan inflamasi yang merupakan hasil dari interaksi yang kompleks antara periodontopathogens dan respon imun host. Periodontitis mengakibatkan hilangnya gigi dan bahkan dapat menyebabkan penyakit sistemik jika tidak diobati. Cairan sulkus gingiva (GCF) mencerminkan kondisi gingiva dan mengandung protein yang tertransudasi dari serum atau sel pada lokasi radang. Infiltrasi polymorphonuclear leukosit (PMN) dapat dilihat pada setiap tahap periodontitis. Laktoferin adalah salah satu granula spesifik PMN dan bisa menjadi indicator aktivitas PMN. Tujuan: Tujuan penelitian ini adalah untuk meneliti intensitas band laktoferin dapat sebagai biomarker periodontitis. Metode: Cairan sulkus gingiva (GCF) dari tiap sampel dikumpulkan menggunakan paper pint no. 30 dari 40 subjek, 30 pasien dengan periodontitis yang dibagi sesuai dengan tingkat keparahan (10 periodontitis ringan, 10 periodontitis moderat, dan 10 periodontitis parah) dan 10 kontrol, mulai usia 20-35 tahun. GCF lactoferrin dianalisis dengan Western blot dan diukur intensitas bandnya dengan quantity one software (bio-rad). Hasil: Pada jaringan yang mengalami periodontitis menunjukkan intensitas band yang secara signifikan lebih besar dari laktoferin daripada periodontal yang sehat. Intensitas band laktoferin berkorelasi positif dengan tingkat keparahan periodontitis (α = 0,05) Simpulan: Hasil penelitian ini menyimpulkan bahwa intensitas band protein laktoferin dapat digunakan sebagai biomarker periodontitis.
Curcumin in Turmeric (Curcuma longa L.) for Treatment of Oral Lichen Planus: A Narrative Review Purwaningrum, Vegananda Wahyu; Elizabeth, Laurencia Dwiamanda; Pratiwi, Chandrasasi Berlian; Nugraha, Ilyas Yakob Nurul; Setiawan, Kresna Erlangga; Maulina, Syafriaz Zulfa; Rahmah, Shafwa Aisha; Shallomitha, Aginta Gracia; Firjani, Putri Nabila; Supandji, Rafaelle Raditya; Salsabila, Alisya Rachel; Islamy, Azzahra Hasnur; Livesey, Gisele Nefertari Love; Masitoh, Hindun Fitria; Fadila, Okta Mulia Nur; Putri, Destiana Hardianti; Cinantya, Aulia Dian; Syahdiar, Aura Zalfa Ghassani; Wati, Sisca Meida; Rahayu, Retno Pudji; Budhy, Theresia Indah; Banerjee, Abhishek
Indonesian Journal of Dental Medicine Vol. 7 No. 1 (2024): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v7i1.2024.40-43

Abstract

Background: Turmeric (Curcuma longa L.) has long been used as a traditional medicine. The primary active component of turmeric is curcumin. It has potential anti-inflammatory effects and high antioxidant activity. Curcumin contained in turmeric has been reported as an effective treatment for Oral lichen planus (OLP). OLP is a chronic autoimmune, inflammatory disease of the oral mucosa associated with systemic disease. This disease involves the skin and mucous membranes (mucocutaneous) of stratified squamous epithelium. Purpose: This narrative review conducted on Google Scholar, PubMed, Research Gate, and ScienceDirect databases aims to study the effectiveness of curcumin contained in Turmeric (C. longa L.)   in OLP treatment. Review(s): OLP is a condition of the oral mucosa that is a chronic autoimmune mucocutaneous disease. As many as 0.5% to 2.2% of cases of OLP occur in the adult population. Systemic and topical corticosteroid drugs are usually used to treat OLP. However, the use of these drugs has many side effects, so it needs searching for a new active substance to treat OLP. Curcumin is a hydrophobic polyphenol extracted from the rhizome of the herb Curcuma longa (turmeric), which has a low molecular weight. The repeated use of steroids can cause side effects that cause atrophy of the mucosa and candidiasis. One natural product that is superior to corticosteroids is curcumin. This is due to curcumin's anti-inflammatory, antioxidant, and chemopreventive properties in several diseases. Conclusion: This review suggests that OLP treatment using curcumin in Turmeric (C. longa L.)   is effective because curcumin exhibits antioxidant, anti-inflammatory, antimicrobial, and anticarcinogenic activities, as well as immunomodulatory properties.
MicroRNA-21 expression as a novel diagnostic and prognostic biomarker in oral cancer: A narrative review Llahfi, Yasminia Sambac Shofie Putri; Zafar, Anis Fatimah; ZV, Astrid Faradia; Pandora, Imelda Prisca; SD, Alfonsus Sindhu; NA, Muhammad Rafi; Widyanti, Salma Putri; Andrew, Emmanuel; Eliya A, Salsabilla; Alfisaida, Aliyya; Qadira R, Malika; Rodhiyah B, Aimmatur; Ramadhani, Puspita; Indriani, Ratri; Salim, Achmad Faishal; Septyan A, Ciptantyo; Rachmad C, Alfin; Mujahidah, Amirah; Wati, Sisca Meida
Indonesian Journal of Dental Medicine Vol. 7 No. 2 (2024): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v7i2.2024.73-76

Abstract

Background: Oral cancer is a life-threatening disease that has 377.713 new cases every year and 60% of the 5-year overall survival rate globally. Approximately 84–97% of oral cancer arises from squamous cells, categorized as oral squamous cell carcinoma (OSCC). MiR-21 is a single-stranded, non-coding RNA that has been studied for its role in carcinogenesis. Overexpression of miR-21 is found in various cancers and is linked to a poor prognosis. However, few studies analyze the expression of miR-21 as a diagnostic and prognostic biomarker in oral cancer. Purpose: This review aimed to describe the expression of miR-21 as a novel diagnostic and prognostic biomarker in oral cancer. Review: MiR-21 was found to be upregulated in various cancers, including oral cancer. miR-21 targets several tumor suppressors such as PTEM, TPM1, and PDCD4 to modulate characteristics linked to cancer prognosis, including cell proliferation, apoptosis, invasion, and metastasis. Furthermore, the constant increase of miR-21 expression in healthy oral mucosa to oral potentially malignant disease to OSCC demonstrated its diagnostic value. Conclusion: miRNA-21 may act as a novel diagnostic and prognosticbiomarker of oral cancer.
External beam radiation therapy for oral squamous cell carcinoma: A narrative review Fahira, Jihan; Rifasky, Akmalisnani Putri; Pakphan, Mileniatri Evriany Lestari; Puspa L, Lusia Dinda; Putri, Yasmin Kamila; Darojah, Zakiyyah; Rohita Z, Dhea Rima; Ilhamuddin K, Haedar; Salwa SS, Jasmine; Benedictine O, Gabriella; Fadiyah, Malika; Rahmi, Adila Dzakiyya; Hurun’in, Arini; Fajrin, Farah Richana; Nurfitri, Aisyah Qonita; Azriella, Covina Reyhana; Diva, Annisa Tiara; Loveisca, Moza Zikra; Diandhary B, Ni Nengah; Wati, Sisca Meida
Indonesian Journal of Dental Medicine Vol. 8 No. 1 (2025): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v8i1.2025.46-48

Abstract

Background: Oral cancer is a malignancy that occurs in the oral cavity. Many factors cause oral cancer, namely alcohol consumption, tobacco smoking, smokeless tobacco, chronic irritation, and others. external beam radiation therapy (EBRT) is a technology commonly used in the standard treatment of head and neck cancer. Purpose: The aim of this review was to determine the effectiveness of EBRT for oral squamous cell carcinoma. Review: Lip carcinoma has a higher chance of healing compared to other cancers that usually appear in the neck and head. Lip carcinoma can be cured through radiation therapy, namely external beam radiation therapy (EBRT). EBRT can be combined withbrachytherapy, which can improve cancer healing. Conclusion: EBRT can be used for oral squamous cell carcinoma cancer treatment. However, there are some disadvantages of EBRT that need to be reviewed based on the conditions in the patient’s case.
Mdm2 Gene as Transcriptional Protein Antagonist of P53 in OSCC with Mir-218 Expression Hanif, Hilmy Irsyadi; Zafar, Anis Fatimah; Puteri, Astari; Wati, Sisca Meida; Rahayu, Retno Pudji
Bhakta Dental Journal Vol 2 No 02 (2024): Desember
Publisher : Fakultas Kedokteran Gigi IIK Bhakti Wiyata, Kediri.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/bhaktadent.v2i02.47

Abstract

Background: Murine double minute-2 (Mdm-2) gene expressed overly to the various type of human cancers. Murine double minute-2 associates with p53 affecting negatively with its gene products for activation of its transcriptional function. These genes mainly expressed in oral squamous cell carcinomas with p53 mutation condition. MicroRNAs nowadays becoming a promising diagnostic and prognostic biomarkers for malignancy through the expression and regulating the transcriptional function. It is reported that mir-218 expression may indicate the occurrence of OSCC. Purpose: The literature describes the putative pathway and function of mdm2 gene as transcriptional antagonist function of p53 in OSCC of mir-218 expression. Review(s): The relationship of mdm2 with mir-218 expression in OSCC may indicate the alternative mechanism of p53 dysfunction condition. Downregulated mir-218 will tend less binding to promoter of p53 causing the mutant state. The overexpression of mdm-2 may constitute inactivation of p53. Conclusion: The study findings may suggest mdm2 protein causing in OSCC due alternative mechanism of p53 as downregulated expression of mir-218.
The diagnostic challenges and two-step surgical approach to an infected dentigerous cyst resembling a unicystic ameloblastoma: A case report Suryabharata, Cokorda Gde; Rizqiawan, Andra; Mulyawan, Indra; Wati, Sisca Meida; Rahman, Mohammad Zeshaan
Dental Journal (Majalah Kedokteran Gigi) Vol. 56 No. 3 (2023): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i3.p202-207

Abstract

Background: A dentigerous cyst is the second-most frequently observed odontogenic cyst, and an ameloblastoma is one of the most frequently observed odontogenic tumors. Both are mostly associated with an impacted mandibular third molar and have similar characteristics. Diagnostic difficulties often result in misdiagnosis and remain a challenge to overcome. Comprehensive clinical, radiographic, and histopathological views are essential to correctly diagnose the problem and formulate the most suitable treatment plan. Purpose: This case report aims to present a thorough approach to the diagnostic and surgical procedures involved in treating a dentigerous cyst that resembles an ameloblastoma by using marsupialization followed by enucleation. Case: This article presents the case report of a 27-year-old male patient with an infected dentigerous cyst resembling a unicystic ameloblastoma associated with a totally impacted lower mandibular left third molar. The patient had a history of swelling, pain, and pus drainage in the retromolar area. Symptoms subsided after antibiotic and analgesic prescriptions, but the lesion remained and was slowly progressing. The diagnostic approach began with a fine-needle aspiration biopsy, and the result confirmed a benign cystic lesion that was suspected to be an odontogenic tumor. Then an incisional biopsy was conducted under local anesthesia, diagnosing an infected dentigerous cyst. Case Management: Marsupialization and decompression using an obturator was preferred, followed by enucleation. Nine months later, a radiographic examination revealed satisfactory bone regeneration without recurrence. Conclusion: An incisional biopsy plays a vital role in establishing a definitive diagnosis. Marsupialization followed by enucleation offers an excellent combination of treatments achieving complete cyst removal, anatomical structure preservation, and bone regeneration with minimal complications.
DISTRIBUTION AND FREQUENCY OF MALIGNANT LYMPHOMA AT RSUD DR. SOETOMO BETWEEN 2013 - 2023 Wati, Sisca Meida; Budhy, Theresia Indah; Fidari, Nadila Tahta; Nazhifa, Amira; Zulfa, Najwa Aulina; Ridholia, Ridholia
Dentino: Jurnal Kedokteran Gigi Vol 10, No 2 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i2.24174

Abstract

Background: Malignant lymphoma is a type of cancer caused by the proliferation of abnormal lymphocyte cells. In Indonesia, Non-Hodgkin's Lymphoma is ranked seventh as the most common new malignancy, while Hodgkin's Lymphoma is ranked 27th. Information on malignant lymphoma in East Java, especially Surabaya, is still limited, especially for a period of more than five years. Therefore, a ten-year study was conducted to gain a more comprehensive understanding of its distribution and frequency. Purpose: To obtain an overview of the distribution and frequency level of malignant lymphoma cases at Dr. Soetomo Hospital, Surabaya in the period 2013-2023. Methods: This observational study with a descriptive approach involved 382 patients as samples, which were analyzed based on the variables of age, gender, type of work, area of residence, anatomical location of the tumor, and size of the tumor. Results: Non-Hodgkin's Lymphoma was found to more dominant (59.4%) compared to Hodgkin's Lymphoma (40.6%). Cases were more common in men (57.3%) than women (42.7%), with the largest age group being in the range of 51–60 years. The majority of patients came from East Java Province, especially Surabaya, and were most often found in individuals working in the private sector (28.8%). The most common anatomical location was the nodal area, with the most common tumor size being less than 2 cm in diameter. Conclusion: This study presents the latest data on the distribution of malignant lymphoma at Dr. Soetomo Hospital, Surabaya and is expected to be a reference for further epidemiological research.  Keywords: distribution, frequency, hodgkin lymphoma, malignant lymphoma, non-hodgkin lymphoma
Oral Maxillofacial Pathology Specialist and AI Supported for Histopathological Diagnosis of Oral Lesions Muhammad, Ilham Nur; Al Fessi, Reza; Wati, Sisca Meida
Frontiers on Healthcare Research Vol. 3 No. 1 (2026)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v3.n1.p18-23.2026

Abstract

Background: Histopathological (HPA) analysis is the gold standard for oral lesions. However, clinical diagnoses often have low agreement rates (44.1%). Artificial intelligence (AI) may offer diagnostic assistance, but its accuracy requires critical evaluation. Purpose: This study compared the diagnostic accuracy of AI models, ChatGPT and Gemini, in interpreting HPA images of oral maxillofacial lesions to the gold standard diagnosis from Oral and Maxillofacial Pathology (OMP) specialists. Methods: This analytical observational study used 54 digital HPA slides from a university research center. The diagnoses generated by ChatGPT and Gemini were evaluated for agreement ('Correct' or 'Incorrect') with the definitive diagnoses made by OMP specialists. Ethical approval was obtained.  Results: Gemini demonstrated a diagnostic accuracy of 74.07% (40 of 54 cases), while ChatGPT achieved 70.37% (38 of 54 cases). The most common lesions were mucoceles and dentigerous cysts. A statistically significant difference (<0.001) was observed between the accuracy of both AI models and the OMP specialist. Conclusion: AI models showed considerable ability to recognize histopathological patterns, but their accuracy was significantly lower than OMP specialists. AI is an augmentative tool for triage or learning but cannot replace the role of OMP specialists in establishing a definitive diagnosis.
Co-Authors Al Fessi, Reza Alfisaida, Aliyya Andra Rizqiawan Andrew, Emmanuel Azriella, Covina Reyhana Banerjee, Abhishek Benedictine O, Gabriella Cinantya, Aulia Dian Darojah, Zakiyyah Diandhary B, Ni Nengah Diva, Annisa Tiara Eliya A, Salsabilla Elizabeth, Laurencia Dwiamanda Fadila, Okta Mulia Nur Fadiyah, Malika Fahira, Jihan Fajrin, Farah Richana Fidari, Nadila Tahta Firjani, Putri Nabila Hanif, Hilmy Irsyadi Hurun’in, Arini Ilhamuddin K, Haedar Indriani, Ratri Islamy, Azzahra Hasnur Istiati Istiati Livesey, Gisele Nefertari Love Llahfi, Yasminia Sambac Shofie Putri Loveisca, Moza Zikra Masitoh, Hindun Fitria Maulina, Syafriaz Zulfa Muhammad, Ilham Nur Mujahidah, Amirah NA, Muhammad Rafi Nazhifa, Amira Nugraha, Ilyas Yakob Nurul Nurfitri, Aisyah Qonita Pakphan, Mileniatri Evriany Lestari Pandora, Imelda Prisca Pratiwi Soesilawati Pratiwi, Chandrasasi Berlian Purwaningrum, Vegananda Wahyu Puspa L, Lusia Dinda Puteri, Astari Putri, Destiana Hardianti Putri, Yasmin Kamila Qadira R, Malika Rachmad C, Alfin Rahmah, Shafwa Aisha Rahman, Mohammad Zeshaan Rahmi, Adila Dzakiyya Ramadhani, Puspita Retno Pudji Rahayu Ridholia, Ridholia Rifasky, Akmalisnani Putri Rodhiyah B, Aimmatur Rohita Z, Dhea Rima Salim, Achmad Faishal Salsabila, Alisya Rachel Salwa SS, Jasmine SD, Alfonsus Sindhu Septyan A, Ciptantyo Setiawan, Kresna Erlangga Shallomitha, Aginta Gracia Supandji, Rafaelle Raditya Suryabharata, Cokorda Gde Syahdiar, Aura Zalfa Ghassani Theresia Indah Budhy Sulisetyawati Widyanti, Salma Putri Zafar, Anis Fatimah Zulfa, Najwa Aulina ZV, Astrid Faradia