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All Journal Emerging Science Journal Journal of Biomedical and Techno Nanomaterials
Ali, Omar
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Biochemistry, Genetics & Molecular Biology Environmental Science

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Assessing the Impact of Innovation Processes on Electronic Systems Technology Adoption Ouheda, Salem; Murray, Peter A.; Alam, Khorshed; Ali, Omar
Emerging Science Journal Vol 8, No 5 (2024): October
Publisher : Ital Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28991/ESJ-2024-08-05-02

Abstract

Objectives: This study aims to explore the adoption of electronic health records (EHRs) in the Australian private healthcare sector by integrating three prominent innovation models, namely the Technology Acceptance Model (TAM), the Diffusion of Innovation (DOI) model, and the Technology-Organization-Environment (TOE) framework. The objective of the study is to understand how these combined models might better inform the EHR adoption process and identify the key factors influencing successful implementation. Methods/Analysis: An exploratory qualitative research design employing a phenomenological approach was utilized to investigate the research. Data were collected through semi-structured interviews with senior managers at a private hospital in South-East Queensland. Purposive sampling was employed to select participants, ensuring representation from key decision-makers involved in the EHRs planning process. Thematic analysis, guided by the reflexive thematic analysis (RTA) approach of Braun and Clarke, was used to analyze the data and derive insights into the factors influencing EHRs adoption. Findings: Key findings indicate that perceived usefulness and job relevance (from TAM), innovation attributes and communication channels (from DOI), and technological, organizational, and environmental contexts (from TOE) are critical elements for successful EHRs implementation. The study also highlights the importance of user engagement, comprehensive training, leadership support, and financial resources. Novelty/Improvement: This study offers a novel contribution by integrating the TAM, DOI, and TOE models to provide a more holistic understanding of EHRs adoption in the private healthcare sector. It also introduces the concept of time as a critical innovation artefact, highlighting its significance in the adoption process. Doi: 10.28991/ESJ-2024-08-05-02 Full Text: PDF
TARGETING THE TUMOR MICRO-ENVIRONMENT: NANOPARTICLE-MEDIATED DELIVERY OF IMMUNOMODULATORY DRUGS TO ENHANCE CANCER IMMUNOTHERAPY Ali, Omar; Mohamed, Ahmed; Hassan, Mariam
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 6 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i6.2982

Abstract

The tumor micro-environment plays a central role in regulating antitumor immune responses and represents a major barrier to the effectiveness of cancer immunotherapy. Immunosuppressive cellular components, abnormal vasculature, and inhibitory cytokine networks often limit immune cell infiltration and reduce the efficacy of systemically administered immunomodulatory drugs. This study aims to investigate nanoparticle-mediated delivery strategies to selectively target the tumor micro-environment and enhance cancer immunotherapy outcomes. An experimental nanomedicine approach was employed, involving the design and characterization of drug-loaded nanoparticles, evaluation of biodistribution and tumor localization, and assessment of immunological responses in tumor models. Nanoparticle performance was compared with free drug administration to determine delivery efficiency and therapeutic impact. The results demonstrate that nanoparticle-mediated delivery significantly improved accumulation of immunomodulatory drugs within tumor tissues, leading to enhanced cytotoxic T cell infiltration, reduced immunosuppressive cell populations, and improved antitumor efficacy. Targeted delivery also reduced off-target immune activation and systemic toxicity compared to conventional administration. In conclusion, nanoparticle-based targeting of the tumor micro-environment offers an effective strategy to overcome immunosuppressive barriers and amplify the therapeutic potential of cancer immunotherapy. This approach provides a promising framework for the development of next-generation precision immuno-oncology treatments.
Co-Authors Hassan, Mariam Khorshed Alam, Khorshed Mohamed, Ahmed Murray, Peter A. Ouheda, Salem