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All Journal EARR Journal of Biomedical and Techno Nanomaterials
Mohamed, Ahmed
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Education Languange, Linguistic, Communication & Media Social Sciences Other

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ASSESSING THE EFFECT OF SCHOOL CULTURE ON INSTRUCTIONAL LEADERSHIP IN MALDIVES Mohamed, Ahmed; Moosa, Visal; Yusoff, Sazali
EARR (Educational Administration Research and Review) Vol 4, No 2 (2020): DECEMBER 2020
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/earr.v4i2.31300

Abstract

Organisational culture and leadership are linked to each other across various organisations including schools. This research attempts to examine the influence of school culture on instructional leadership of principals in schools of Maldives. A total of 145 teachers participated in the study.  The data were statistically analysed using descriptive and inferential statistics. The result showed that all the dimensions of school culture are significantly associated with all the three dimensions of instructional leadership.  The findings also revealed that three dimensions of school culture - ‘professional development’, ‘unity of purpose’ and ‘teacher collaboration’ - have a significant impact on instructional leadership. Based on the statistical results, implications of the findings were discussed in the context of school culture, and leadership. Consequently, suggestions for future research were also explored.
TARGETING THE TUMOR MICRO-ENVIRONMENT: NANOPARTICLE-MEDIATED DELIVERY OF IMMUNOMODULATORY DRUGS TO ENHANCE CANCER IMMUNOTHERAPY Ali, Omar; Mohamed, Ahmed; Hassan, Mariam
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 6 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i6.2982

Abstract

The tumor micro-environment plays a central role in regulating antitumor immune responses and represents a major barrier to the effectiveness of cancer immunotherapy. Immunosuppressive cellular components, abnormal vasculature, and inhibitory cytokine networks often limit immune cell infiltration and reduce the efficacy of systemically administered immunomodulatory drugs. This study aims to investigate nanoparticle-mediated delivery strategies to selectively target the tumor micro-environment and enhance cancer immunotherapy outcomes. An experimental nanomedicine approach was employed, involving the design and characterization of drug-loaded nanoparticles, evaluation of biodistribution and tumor localization, and assessment of immunological responses in tumor models. Nanoparticle performance was compared with free drug administration to determine delivery efficiency and therapeutic impact. The results demonstrate that nanoparticle-mediated delivery significantly improved accumulation of immunomodulatory drugs within tumor tissues, leading to enhanced cytotoxic T cell infiltration, reduced immunosuppressive cell populations, and improved antitumor efficacy. Targeted delivery also reduced off-target immune activation and systemic toxicity compared to conventional administration. In conclusion, nanoparticle-based targeting of the tumor micro-environment offers an effective strategy to overcome immunosuppressive barriers and amplify the therapeutic potential of cancer immunotherapy. This approach provides a promising framework for the development of next-generation precision immuno-oncology treatments.
Co-Authors Ali, Omar Hassan, Mariam Moosa, Visal Yusoff, Sazali