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All Journal Acta Pharmaceutica Indonesia Jurnal Abdimas Kesehatan
Ramadhani, Chelsea Aulia
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Medicine & Pharmacology

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INVOLVEMENT ARACHIDONIC ACID CASCADE IN MEMORY DEFICIT BY KRATOM (Mitragyna speciosa) IN MALE WISTAR RATS Ramadhani, Chelsea Aulia; Anggadiredja, Kusnandar
Acta Pharmaceutica Indonesia Vol. 49 No. 01 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v49i01.23562

Abstract

Kratom (Mitragyna speciosa) is a plant that is widely found in Southeast Asia particularly, in Indonesia. Mitragynine, which was the main alkaloid of kratom, has been reported associated with addictiveness and memory impairment in animal studies. However, the mechanism of memory impairment is still unclear. In the present study, we investigated the involvement of the arachidonic acid cascade in memory impairment caused by kratom. Male Wistar rats were divided into seven groups, namely vehicle (CMC Na 0.5%; oral), kratom ethanolic extract (50, 100 and 200 mg/Kg; oral (p.o)), and the group given Diclofenac Sodium (5 mg /Kg; Intraperitonial (i.p)) 30 mins before administration of kratom ethanolic extract (50, 100 and 200 mg/Kg; oral) for 14 days. Memory impairment was carried out using a spatial memory test on days 10-16 using the Morris Water Maze and a working memory test using the Y Maze on the 17th day. Kratom administration was shown to impair spatial memory and working memory when compared with the vehicle group (P<0.05). Diclofenac sodium prevents spatial memory and working memory impairment due to Kratom when compared to the group administered by kratom monotherapy at the equivalent dose (P<0.05). In this study, it was found that there was involvement of the arachidonic acid cascade in memory impairment by kratom.
UPAYA PENINGKATAN KESADARAN MASYARAKAT LANJUT USIA DALAM TATALAKSANA PENYAKIT KOLESTEROL DAN HIPERTENSI KRONIK SERTA KOMPLIKASINYA DI DESA JATISARI, MAJASEM, NGAWI Sawitri, Satwika Budi; Jasmine, Fashabilla Firstlanda; Rohmah, Alifia; Anjani, Rara Sativa; Milawati, Ridha Ayu; Kurniawan; Ramadhani, Chelsea Aulia
Jurnal Abdimas Kesehatan (JAKes) Vol. 3 No. 1 (2025): Jurnal Abdimas Kesehatan (JAKes)
Publisher : PC IAI Sragen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/jakes.v3i1.92

Abstract

Hipertensi dan kolesterol tinggi merupakan salah satu penyakit yang sering ditemuai di masyarakat, terutama di daerah pedesaan seperti Desa Majasem dusun Jatisari, Jawa Timur. Komplikasinya terhadap gangguan kardiovaskuler menjadikan kewaspadaan yang perlu ditangani dan ditanamkan kesadarannya terhadap para penderitanya. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan kesadaran masyarakat tentang pentingnya pengelolaan kolesterol dan hipertensi melalui edukasi dan pemeriksaan Kesehatan. Metode yang digunakan meliputi penyuluhan Kesehatan guna mengedukasi masyarakat, pemeriksaan tekanan darah secara gratis, serta pendistribusian bahan edukasi. Edukasi yang diberikan berhasil meningkatkan pemahaman masyarakat tentang pola makan sehat, aktivitas fisik, dan pentingnya pemeriksaan Kesehatan rutin. Kegiatan ini diharapkan dapat menjadi Langkah awal untuk mengurangi prevalensi hipertensi dan kolesterol tinggi di Dusun Jatisari. Keimpulannya bahwasanya masalah penyakit kardiovaskuler dan komplikasnya dapat diatasi untuk meningkatkan kualitas hidup pasien dengan adanya sinergi dari faskes tingkat pertama dan kesadaran oleh masyarakat secara luas cara pencegahan dan tatalaksananya sehingga meminimakan terjadinya komplikasi lebih lanjut.
Co-Authors Anjani, Rara Sativa Jasmine, Fashabilla Firstlanda Kurniawan, Kurniawan Kusnandar Anggadiredja Milawati, Ridha Ayu Rohmah, Alifia Sawitri, Satwika Budi