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Computational Study of N-Hexane Extract of Jotang Herba (Acmella uliginosa) Nabillah, Deya Adiby; Kholifah, Eva; Ahmaddhani, Surya
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8268

Abstract

The study investigates the in silico toxicity of n-hexane extract from Acmella uliginosa (Jotang) herb, a plant widely used in traditional medicine. In silico methods, such as molecular docking, toxicity prediction, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, were employed to assess the potential harmful effects of the extract’s chemical constituents. The primary aim was to evaluate the safety profile of the extract in terms of cytotoxicity, mutagenicity, and organ toxicity. The study used computational tools like Pre.ADMET to predict various toxicological endpoints based on the molecular properties of the compounds identified in the n-hexane extract. The results suggested that while some compounds exhibited low toxicity risk, others showed potential mutagenic or hepatotoxic effects. This in silico approach provides a rapid and cost-effective method for preliminary toxicity assessment, offering valuable insights for further in vivo or clinical studies. The findings underscore the importance of integrating computational techniques into the safety evaluation of herbal medicines.
Tingkat Pengetahuan Karang Taruna Cahaya Mandala dalam Pembuatan Kombucha Bunga Kecombrang di Desa Mandalawangi Kholifah, Eva; Nabillah, Deya Adiby; Suhaemi, Muhamad; Endah, Endah; Ismiyati, Renditya; Anton, Anton; Asep, Asep; Maulana, Balqis; Ahmaddhani, Surya; Nabilah, Syala
Jurnal Medika: Medika Vol. 4 No. 4 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/gena5b10

Abstract

This community service activity was motivated by the potential of local natural resources in the form of Torch Ginger flowers (Etlingera elatior) in Mandalawangi Village, Pandeglang Regency, which have not been optimally utilized despite their high antioxidant activity and potential to be processed into probiotic kombucha beverages that are beneficial for health and possess economic value. The purpose of this activity was to improve the knowledge and skills of members of the Karang Taruna Cahaya Mandala in producing Torch Ginger flower kombucha as an effort to enhance public health and welfare. The activity was carried out through interactive lectures, hands-on training, and counseling using leaflet media, involving 30 respondents selected based on their active participation in the community. Knowledge evaluation was conducted through pretest and posttest assessments using the Wilcoxon test to analyze significant differences in knowledge levels before and after the activity. The results showed an increase in the knowledge level categorized as “good” from 63% before the training to 90% after the training, with a significance value of p = 0.000 (p<0.05), indicating that the activity was effective in improving participants’ understanding of Torch Gingerflower kombucha production. In addition to increasing health awareness, this activity also contributed positively to community economic empowerment through the development of local value-added products. In conclusion, the training and counseling on Torch Ginger flower kombucha production proved effective in enhancing community knowledge and skills; however, further activities are recommended, including business mentoring and product certification, to ensure the sustainability and broader impact of the program.