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All Journal Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Biologi Tropis Journal of Fundamental and Applied Pharmaceutical Science Jurnal Ilmiah Bakti Farmasi Journal of Biotechnology and Natural Science Jurnal Ilmiah Kesehatan Delima Parapemikir Jurnal Ilmiah Farmasi Jurnal Farmasi Galenika
Kholifah, Eva
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Formulation and Antioxidant Activity Analysis of Jotang Herb (Acmella paniculata) Extract Mask Cream Kholifah, Eva; Fitriani, Via; Shobah, Afifah Nur
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.19341

Abstract

Pollution in the environment can increase the production of reactive oxygen species (ROS), which can reduce the amount of antioxidants in the skin. Antioxidants are compounds that can inhibit oxidation reactions by binding to free radicals and reactive molecules. Herbaceous plant jotang (Acmella paniculata) has secondary metabolites such as flavonoids, alkaloids, tannins, and saponins, which can protect the internal and external organs of the body's cells from damage caused by free radicals on the skin. One of the treatment preparations used for the skin is a cream mask, as the use or application at the final level of skin care can improve cleanliness and health and stimulate and repair skin cells. This study aims to determine a formula that has a good antioxidant value using the DPPH method (2,2-diphenyl-1-pikrilhidrazyl). In this study, preparations were made with 3 formulas, namely Formula I (1% w/w), Formula II (10%w/w), and Formula 0 (Control). Evaluation of physical properties included organoleptic tests, homogeneity tests, spreadability tests, pH tests, viscosity tests, cream-type tests, and antioxidant tests. The result showed that the organoleptic test had a cream mask dosage in the form of semi-solid, distinctive jotang odor, light and dark green, had a homogeneous dosage form, spreadability around 5.1-5.7 with an average pH value of 6, had a good viscosity value and had a type of cream M/A and a high antioxidant value in formula II (10% w/w ) with an IC50 value of 21.959 μg/ml. Based on statistical tests, significant results were obtained of 0.000p (0.05) so that it can be interpreted that there was a significant difference in each concentration of jotang herb extract to the resulting IC50 value.
Literature Review: Mekanisme Kerja Obat Antidislipidemia Udin, Baha; Kholifah, Eva
Jurnal Ilmiah Bakti Farmasi Vol 6 No 1 (2021): Jurnal Ilmiah Bakti Farmasi
Publisher : Lembaga Penelitian & Pengabdian Kepada Masyarakat (LPPM) STIFI Bhakti Pertiwi Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61685/jibf.v6i1.75

Abstract

Dislipidemia merupakan kondisi tubuh manusia yang memiliki kadar lipid yang abnormal. Penggunaan obat merupakan salah satu metode yang ideal untuk menangani pasien dislipidemia. Saat ini, terdapat cukup bervariasi golongan obat yang digunakan untuk mengatasi dislipidemia dengan memiliki mekanisme kerja nya masing-masing. Berdasarkan mekanisme kerja obat antidislipidemia saat ini terdapat tujuh golongan, seperti golongan statin, fibrat dan derivatnya, bile acid sequestrants (bass), ezetimibe, asam nikotinik dan derivatnya, PCSK9 inhibitor, asam lemak omega-3. Terdapat perbedaan target dan mekanisme kerja suatu golongan obat.
Eksplorasi Toksisitas Ekstrak N-Hexan dan Aseton Telur Keong Mas (Pomacea canaliculata) Secara In Vitro dan In Silico Kholifah, Eva; Alifia A.T, Mohammad; Nur S, Afifah
Jurnal Ilmiah Bakti Farmasi Vol 7 No 1 (2022): Jurnal Ilmiah Bakti Farmasi
Publisher : Lembaga Penelitian & Pengabdian Kepada Masyarakat (LPPM) STIFI Bhakti Pertiwi Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61685/jibf.v7i1.86

Abstract

Telur keong mas merupakan salah satu hama pada tanaman padi. Namun, saat ini penanggulangan hama padi tersebut diarahkan pada pengembangan obat. Tujuan dari penelitian ini adalah untuk menganalisis potensi toksik yang ditimbulkan oleh ekstrak telur keong mas secara in silico. Kemudian dilakukan analisis secara in vitro untuk melihat potensi toksik pada larva Artemia salina denganmetode Brine Shrimp Lethality Test (BSLT). Selain itu, dilakukan skrining fitokimia dan untuk mengetahui metabolit sekunder yang terkandung dalam ekstrak telur keong mas. Hasil penelitian telur keong mas mengandung senyawa metabolit sekunder yakni alkaloid, flavonoid, steroid, saponin. Pengujian secara komputasi menunjukan senyawa yang terkandung dalam telur keong mas berpotensi menyebabkan toksik pada alga, daphnia. Namun senyawa tersebut tidak menyebabkan mutasi atau non mutagen. Namun hal ini berbanding terbalik dengan pengujian secara in vitro menggunakan artemia salina. Pengujian BSLT menggunakan pelarut aseton memiliki nilai LC50 1161,408 μg/ml dan n-heksana 1303,497 μg/ml. Berdaarkan nilai tersebut ekstrak telur keong mas (Pomacea canaliculata) dinyatakan bersifat tidak toksik terhadap Artemia salina Leach karna nilai LC50 >1000 μg/ml.
Analysis of sildenafil citrate in male stamina herbal medicines from the Magelang region, Central Java using thin-layer chromatography and UV spectrophotometry Saputra, Ilham Fahmi; Haresmita, Perdana Priya; Dianita, Puspita Septie; Kholifah, Eva
Acta Pharmaciae Indonesia Vol 12 No 1 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.1.11964

Abstract

Background: Male stamina herbal medicines are widely consumed in Indonesia, often believed to enhance sexual performance. However, the illegal addition of medicinal chemicals (BKOs) such as sildenafil citrate in traditional herbal products poses health risks. Objective: To identify and quantify sildenafil citrate in selected herbal medicine samples using thin-layer chromatography (TLC) and UV spectrophotometry. Method: Three samples of male stamina herbal medicine were purchased and subjected to organoleptic tests. Ethanol (96%) was used for extraction, followed by TLC analysis using two mobile phases (methanol: chloroform at 4:1 and 1:1 ratios). UV spectrophotometry was employed to determine the maximum absorbance wavelength and quantify sildenafil citrate. Results: TLC analysis revealed that two samples (K and L) contained sildenafil citrate, with Rf values consistent with the standard. UV spectrophotometry confirmed the presence of sildenafil citrate at a maximum wavelength of 292.5 nm. Sample K contained 0.96%, while sample L had 13.766% sildenafil citrate. Conclusion: The presence of sildenafil citrate in two samples violates Indonesian regulations prohibiting medicinal chemicals in herbal products, raising significant safety concerns.
Effect of Particle Size and Extraction Time on Total Flavonoid Level of Artemisia vulgaris Ethanol Extract Kurniasih, Kholif Sholehah Indra; Arifah, Mitsalina Fildzah; Setiyawati, Eka Ayu; Rahmah, Syafira Atika; Widianingrum, Lucia; Kholifah, Eva
Journal of Biotechnology and Natural Science Vol. 4 No. 2 (2024): December
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jbns.v4i2.12045

Abstract

Background: Artemisia vulgaris, also referred to as Daun Baru Cina, is a herbaceous species within the Asteraceae family. Artemisia vulgaris is a traditional remedy for numerous ailments, exhibiting anti-inflammatory and antioxidant properties due to its secondary metabolites, specifically flavonoids. The extraction method is essential for extracting the desired chemical from natural sources intended for therapeutic use. The extraction process is affected by several elements, including the particle size of simplicia powder and the duration of extraction. Objective: This study aims to test the effect of differences in particle size of powdered simplicia and extraction time of Artemisia vulgaris leaves on total flavonoid levels, using 70% ethanol solvent. Researchers used a quantitative approach using a descriptive research design. In this study, a qualitative test was carried out in the form of phytochemical screening followed by a quantitative test to determine the total flavonoid levels of Artemisia vulgaris leaves. Various particle sizes (40 mesh and 80 mesh) and extraction times (12 hours and 36 hours) were used in this study. Using ultraviolet-visible spectrophotometry, the Total Flavonoid Level (TFC) of the ethanol extract of Artemisia vulgaris leaves was determined. Results: The TFC value obtained for the optimal particle size was 40 mesh, with an extraction time of 12 hours, which was 72.073 ± 1.126 mgQE / g extract. While 80 mesh, with an extraction time of 36 hours, gave a TFC value of 70.169 ± 0.480 mgQE / g extract. In addition, 70% ethanol extract of Artemisia vulgaris leaves contains secondary metabolites of phenolic alkaloids, tannins, saponins, and steroids. Conclusion: The study concludes that the quantity of simplicia powder particles and the extraction duration influence the total flavonoid concentrations in Artemisia vulgaris.
Acmella Uliginosa: Farmakologi, Fitokimia, Toksikologi dan Perkembangan Analog: Review Artikel Kholifah, Eva; Kurnia, Nia Marlina; Insani, Nurul
Jurnal Ilmiah Kesehatan Delima Vol. 4 No. 2 (2022): Jurnal Ilmiah Kesehatan Delima
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Sekolah Tinggi Ilmu Kesehatan Salsabila Serang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60010/jikd.v4i2.82

Abstract

Acmella uliginosa is an important medicinal plant, it is found in tropical and subtropical countries especially Indonesia, India and South America. This plant known as a toothache plant which is usually used to reduce pain associated with toothache. Various extracts and active metabolites from various parts of this plant have beneficial pharmacological activities. Several studies show Acmella Uliginosa has pharmacological activities such as antimicrobial, antipyretic, antioxidant, and anti-inflammatory. This review in detail describes the traditional uses, phytochemicals, pharmacology, toxicology and development of analogues of the active constituents of this plant. This review will help researchers to find scientific information in the future. Acmella Uliginosa adalah tanaman obat penting, ditemukan di negara-negara tropis dan subtropis terutama Indonesia, India dan Amerika Selatan. Tanaman ini dikenal sebagai tanaman sakit gigi yang biasanya digunkan untuk mengurangi rasa sakit yang berhubungan dengan sakit gigi. Bermacam-macam ekstrak dan metabolit aktif dari berbagai bagian tanaman ini memiliki aktivitas farmakologis yang bermanfaat. Beberapa penelitian menyebutkan Acmella Uliginosa memiliki aktivitas farmakologi seperti antimikroba, antipiretik, antioksidan, dan antiinflamasi. Ulasan ini secara rinci menggambarkan penggunaan tradisional, fitokimia, farmakologi, toksikologi dan perkembangan analog dari konstituen aktiv tanaman ini. Review ini akan membantu peneliti untuk mencari informasi ilmiah di masa depan.
Optimasi Formula Tablet Black Garlic Menggunakan Kombinasi Laktosa dan Avicel Ph 102 dengan Metode Simplex Lattice Design Zahroh, Siti Lailatu; Nurmay Stiani, Sofi; Kholifah, Eva
Jurnal Ilmiah Kesehatan Delima Vol. 5 No. 2 (2023): Jurnal Ilmiah Kesehatan Delima
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Sekolah Tinggi Ilmu Kesehatan Salsabila Serang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60010/jikd.v5i2.95

Abstract

The study aims to find out whether the combination of lactose and avicel pH 102 can be formulated into black garlic extract tablet in accordance with the Indonesian Pharmacopoeia, the influence of combination, and determine the optimum formulation of the two ingredients using the SLD method. Methods used in this research Black Garlic extract is made by maceration method with 96% ethanol solvent with an extract weight of each tablet of 400 mg. Black garlic extract tablets are made in three formulations with a ratio of lactose-avicel PH-102, namely FI (100%:0%), FII (50%:50%), and FIII (0%:100%). Result shows that the optimum formula obtained was 80% lactose and 20% avicel PH 102 with a total predicted value of 0.645. The greater the concentration of avicel PH 102 as a crushing material, the faster the time rate of destruction, the hardness decreases, and the fragility value rises. The higher the concentration of the filler, the longer the crushing time it will take. The results of the statistical analysis of the three formulas tested showed the absence of significant differences between flow time, hardness, and brittleness, while crushed time tests showed the presence of significant differences (p?0.05). Tujuan penelitian ini adalah kombinasi antara laktosa dan avicel pH 102 dapat diformulasikan menjadi sediaan tablet sesuai dengan Farmakope Indonesia, pengaruh tehadap kombinasi dan penentuan formulasi yang optimum dari kedua bahan tersebut dapat dilakukan dengan metode SLD. Metode dalam penelitian ini adalah Ekstrak Black Garlic dibuat dengan metode maserasi dengan pelarut etanol 96% dengan bobot ekstrak setiap tablet 400 mg. Tablet ekstrak black garlic dibuat tiga formulasi dengan perbandingan laktosa-avicel PH-102 yaitu FI (100%:0%), FII (50%:50%) dan FIII (0%:100%). Hasil penelitian menunjukkan bahwa formula optimum yang diperoleh adalah 80% laktosa dan 20% avicel PH 102 dengan total nilai prediksi 0.645. Semakin besar konsentrasi avicel PH 102 sebagai bahan penghancur, maka tingkat waktu hancur semakin cepat, kekerasan semakin turun, nilai kerapuhan semakin naik. Semakin tinggi konsentrasi pengisi, maka semakin lama waktu hancur yang dibutuhkan. Hasil analisis statistik dari ketiga formula yang diuji menunjukkan tidak adanya perbedaan yang signifikan antara waktu alir, kekerasan dan kerapuhan, sedangkan untuk uji waktu hancur menunjukkan adanya perbedaan yang signifikan (p?0.05).
Antibacterial Activity of Jotang Flower Infusion (Acmella paniculata) against Staphylococcus aureus Skania, Pratiwi Cahya; Kholifah, Eva; Agustin, Siti
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7877

Abstract

Among its various uses, the plant Jotang (Acmella paniculata), which is a member of the Asteraceae family, possesses antibacterial and anti-infective properties in its floral section. The majority of diseases are caused by the Streptococcus aureus bacteria. The purpose of this study was to evaluate the antibacterial activity of jotang flower infusion against Streptococcus mutans at doses of 75%, 50%, and 25%. The antibacterial activity was evaluated using the agar diffusion method, with chloramphenicol acting as a positive control. At 25%, 50%, and 75% dosages, the average inhibition zone diameter in the jotang inhibition test was 5.00 mm, 6.00 mm, and 6.06 mm, respectively. Chloramphenicol, the positive control, had a measurement of 9.96 mm. According to the study's results, jotang flower infusion has a somewhat effective antibacterial effect on Streptococcus aureus.
Computational Study of N-Hexane Extract of Jotang Herba (Acmella uliginosa) Nabillah, Deya Adiby; Kholifah, Eva; Ahmaddhani, Surya
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8268

Abstract

The study investigates the in silico toxicity of n-hexane extract from Acmella uliginosa (Jotang) herb, a plant widely used in traditional medicine. In silico methods, such as molecular docking, toxicity prediction, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, were employed to assess the potential harmful effects of the extract’s chemical constituents. The primary aim was to evaluate the safety profile of the extract in terms of cytotoxicity, mutagenicity, and organ toxicity. The study used computational tools like Pre.ADMET to predict various toxicological endpoints based on the molecular properties of the compounds identified in the n-hexane extract. The results suggested that while some compounds exhibited low toxicity risk, others showed potential mutagenic or hepatotoxic effects. This in silico approach provides a rapid and cost-effective method for preliminary toxicity assessment, offering valuable insights for further in vivo or clinical studies. The findings underscore the importance of integrating computational techniques into the safety evaluation of herbal medicines.
Pengaruh Edukasi Terhadap Tingkat Pengetahuan Pengobatan Medis Pada Santri Pondok Pesantren Al-Hikmat Dan Nurul Hikmat Pandeglang Banten Yusransyah, Yusransyah; Lukmanul Hakim, Imam; Kholifah, Eva
JURNAL FARMASI GALENIKA Vol 9 No 2 (2022): Jurnal Farmasi Galenika Vol 9 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v9i2.219

Abstract

Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan santri pondok pesantren Al-Hikmat dan Nurul Hikmat tentang pengobatan medis sebelum dan setelah diberikan edukasi, serta mengetahui adanya pengaruh pemberian edukasi terhadap tingkat pengetahuan pengobatan medis pada santri pondok pesantren Al-Hikmat dan Nurul Hikmat. Manfaat penelitian ini dapat memberikan gambaran melalui data penelitian yang diperoleh tentang pengaruh pemberian edukasi terhadap peningkatan pengetahuan pengobatan medis pada santri pondok pesantren Al-Hikmat dan Nurul Hikmat. Penelitian ini diharapkan mampu meningkatkan pengetahuan santri pondok pesantren Al-Hikmat dan Nurul Hikmat dalam pengobatan medis. Metode penelitian Pre-Experimental Designs dengan teknik pengumpulan data pretest dan posttest pada santri di pondok pesantren Al-Hikmat dan Nurul Hikmat. Data hasil penelitian di analisis menggunakan program SPSS (kolmogorov-smirnov two sample test dan paired samples t-test). Hasil penelitian menunjukan bahwa tingkat pengetahuan santri bertambah setelah diberikan edukasi. Hal ini dibuktikan dengan hasil uji statistik t-test berpasangan, yang diperoleh nilai p= 0,000 yang mana nilai tersebut kurang dari 0,05.
Co-Authors Agustin, Siti Ahmaddhani, Surya Alfiyah, Siti Alifia A.T, Mohammad Arifah, Mitsalina Fildzah Aziya, Hasna Baha Udin Cahya Skania, Pratiwi Fajrin Noviyanto, Fajrin Fitriani, Via Kurnia, Nia Marlina Kurniasih, Kholif Sholehah Indra Lukmanul Hakim, Imam Nabillah, Deya Adiby Nur Insani Nur S, Afifah Perdana Priya Haresmita, Perdana Priya Puspita Septie Dianita, Puspita Septie R, Asti Yunia Rahmah, Syafira Atika Saputra, Ilham Fahmi Setiyawati, Eka Ayu Shobah, Afifah Nur Stiani, Sofi Nurmay Widianingrum, Lucia Yusransyah, Yusransyah Zahroh, Siti Lailatu