Article Per Year (5 Year)
p-Index From 2021 - 2026
2.049
P-Index
This Author published in this journals
All Journal Jurnal Biologi Tropis Journal of Fundamental and Applied Pharmaceutical Science Jurnal Ilmiah Bakti Farmasi Journal of Biotechnology and Natural Science Parapemikir Jurnal Ilmiah Farmasi Jurnal Farmasi Galenika
Kholifah, Eva
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

Published : 10 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 10 Documents
Search

 1 
Formulation and Antioxidant Activity Analysis of Jotang Herb (Acmella paniculata) Extract Mask Cream Kholifah, Eva; Fitriani, Via; Shobah, Afifah Nur
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.19341

Abstract

Pollution in the environment can increase the production of reactive oxygen species (ROS), which can reduce the amount of antioxidants in the skin. Antioxidants are compounds that can inhibit oxidation reactions by binding to free radicals and reactive molecules. Herbaceous plant jotang (Acmella paniculata) has secondary metabolites such as flavonoids, alkaloids, tannins, and saponins, which can protect the internal and external organs of the body's cells from damage caused by free radicals on the skin. One of the treatment preparations used for the skin is a cream mask, as the use or application at the final level of skin care can improve cleanliness and health and stimulate and repair skin cells. This study aims to determine a formula that has a good antioxidant value using the DPPH method (2,2-diphenyl-1-pikrilhidrazyl). In this study, preparations were made with 3 formulas, namely Formula I (1% w/w), Formula II (10%w/w), and Formula 0 (Control). Evaluation of physical properties included organoleptic tests, homogeneity tests, spreadability tests, pH tests, viscosity tests, cream-type tests, and antioxidant tests. The result showed that the organoleptic test had a cream mask dosage in the form of semi-solid, distinctive jotang odor, light and dark green, had a homogeneous dosage form, spreadability around 5.1-5.7 with an average pH value of 6, had a good viscosity value and had a type of cream M/A and a high antioxidant value in formula II (10% w/w ) with an IC50 value of 21.959 μg/ml. Based on statistical tests, significant results were obtained of 0.000p (0.05) so that it can be interpreted that there was a significant difference in each concentration of jotang herb extract to the resulting IC50 value.
Literature Review: Mekanisme Kerja Obat Antidislipidemia Udin, Baha; Kholifah, Eva
Jurnal Ilmiah Bakti Farmasi Vol 6 No 1 (2021): Jurnal Ilmiah Bakti Farmasi
Publisher : Lembaga Penelitian & Pengabdian Kepada Masyarakat (LPPM) STIFI Bhakti Pertiwi Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61685/jibf.v6i1.75

Abstract

Dislipidemia merupakan kondisi tubuh manusia yang memiliki kadar lipid yang abnormal. Penggunaan obat merupakan salah satu metode yang ideal untuk menangani pasien dislipidemia. Saat ini, terdapat cukup bervariasi golongan obat yang digunakan untuk mengatasi dislipidemia dengan memiliki mekanisme kerja nya masing-masing. Berdasarkan mekanisme kerja obat antidislipidemia saat ini terdapat tujuh golongan, seperti golongan statin, fibrat dan derivatnya, bile acid sequestrants (bass), ezetimibe, asam nikotinik dan derivatnya, PCSK9 inhibitor, asam lemak omega-3. Terdapat perbedaan target dan mekanisme kerja suatu golongan obat.
Eksplorasi Toksisitas Ekstrak N-Hexan dan Aseton Telur Keong Mas (Pomacea canaliculata) Secara In Vitro dan In Silico Kholifah, Eva; Alifia A.T, Mohammad; Nur S, Afifah
Jurnal Ilmiah Bakti Farmasi Vol 7 No 1 (2022): Jurnal Ilmiah Bakti Farmasi
Publisher : Lembaga Penelitian & Pengabdian Kepada Masyarakat (LPPM) STIFI Bhakti Pertiwi Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61685/jibf.v7i1.86

Abstract

Telur keong mas merupakan salah satu hama pada tanaman padi. Namun, saat ini penanggulangan hama padi tersebut diarahkan pada pengembangan obat. Tujuan dari penelitian ini adalah untuk menganalisis potensi toksik yang ditimbulkan oleh ekstrak telur keong mas secara in silico. Kemudian dilakukan analisis secara in vitro untuk melihat potensi toksik pada larva Artemia salina denganmetode Brine Shrimp Lethality Test (BSLT). Selain itu, dilakukan skrining fitokimia dan untuk mengetahui metabolit sekunder yang terkandung dalam ekstrak telur keong mas. Hasil penelitian telur keong mas mengandung senyawa metabolit sekunder yakni alkaloid, flavonoid, steroid, saponin. Pengujian secara komputasi menunjukan senyawa yang terkandung dalam telur keong mas berpotensi menyebabkan toksik pada alga, daphnia. Namun senyawa tersebut tidak menyebabkan mutasi atau non mutagen. Namun hal ini berbanding terbalik dengan pengujian secara in vitro menggunakan artemia salina. Pengujian BSLT menggunakan pelarut aseton memiliki nilai LC50 1161,408 μg/ml dan n-heksana 1303,497 μg/ml. Berdaarkan nilai tersebut ekstrak telur keong mas (Pomacea canaliculata) dinyatakan bersifat tidak toksik terhadap Artemia salina Leach karna nilai LC50 >1000 μg/ml.
Effect of Particle Size and Extraction Time on Total Flavonoid Level of Artemisia vulgaris Ethanol Extract Kurniasih, Kholif Sholehah Indra; Arifah, Mitsalina Fildzah; Setiyawati, Eka Ayu; Rahmah, Syafira Atika; Widianingrum, Lucia; Kholifah, Eva
Journal of Biotechnology and Natural Science Vol. 4 No. 2 (2024): December
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jbns.v4i2.12045

Abstract

Background: Artemisia vulgaris, also referred to as Daun Baru Cina, is a herbaceous species within the Asteraceae family. Artemisia vulgaris is a traditional remedy for numerous ailments, exhibiting anti-inflammatory and antioxidant properties due to its secondary metabolites, specifically flavonoids. The extraction method is essential for extracting the desired chemical from natural sources intended for therapeutic use. The extraction process is affected by several elements, including the particle size of simplicia powder and the duration of extraction. Objective: This study aims to test the effect of differences in particle size of powdered simplicia and extraction time of Artemisia vulgaris leaves on total flavonoid levels, using 70% ethanol solvent. Researchers used a quantitative approach using a descriptive research design. In this study, a qualitative test was carried out in the form of phytochemical screening followed by a quantitative test to determine the total flavonoid levels of Artemisia vulgaris leaves. Various particle sizes (40 mesh and 80 mesh) and extraction times (12 hours and 36 hours) were used in this study. Using ultraviolet-visible spectrophotometry, the Total Flavonoid Level (TFC) of the ethanol extract of Artemisia vulgaris leaves was determined. Results: The TFC value obtained for the optimal particle size was 40 mesh, with an extraction time of 12 hours, which was 72.073 ± 1.126 mgQE / g extract. While 80 mesh, with an extraction time of 36 hours, gave a TFC value of 70.169 ± 0.480 mgQE / g extract. In addition, 70% ethanol extract of Artemisia vulgaris leaves contains secondary metabolites of phenolic alkaloids, tannins, saponins, and steroids. Conclusion: The study concludes that the quantity of simplicia powder particles and the extraction duration influence the total flavonoid concentrations in Artemisia vulgaris.
Antibacterial Activity of Jotang Flower Infusion (Acmella paniculata) against Staphylococcus aureus Skania, Pratiwi Cahya; Kholifah, Eva; Agustin, Siti
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7877

Abstract

Among its various uses, the plant Jotang (Acmella paniculata), which is a member of the Asteraceae family, possesses antibacterial and anti-infective properties in its floral section. The majority of diseases are caused by the Streptococcus aureus bacteria. The purpose of this study was to evaluate the antibacterial activity of jotang flower infusion against Streptococcus mutans at doses of 75%, 50%, and 25%. The antibacterial activity was evaluated using the agar diffusion method, with chloramphenicol acting as a positive control. At 25%, 50%, and 75% dosages, the average inhibition zone diameter in the jotang inhibition test was 5.00 mm, 6.00 mm, and 6.06 mm, respectively. Chloramphenicol, the positive control, had a measurement of 9.96 mm. According to the study's results, jotang flower infusion has a somewhat effective antibacterial effect on Streptococcus aureus.
Computational Study of N-Hexane Extract of Jotang Herba (Acmella uliginosa) Nabillah, Deya Adiby; Kholifah, Eva; Ahmaddhani, Surya
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8268

Abstract

The study investigates the in silico toxicity of n-hexane extract from Acmella uliginosa (Jotang) herb, a plant widely used in traditional medicine. In silico methods, such as molecular docking, toxicity prediction, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, were employed to assess the potential harmful effects of the extract’s chemical constituents. The primary aim was to evaluate the safety profile of the extract in terms of cytotoxicity, mutagenicity, and organ toxicity. The study used computational tools like Pre.ADMET to predict various toxicological endpoints based on the molecular properties of the compounds identified in the n-hexane extract. The results suggested that while some compounds exhibited low toxicity risk, others showed potential mutagenic or hepatotoxic effects. This in silico approach provides a rapid and cost-effective method for preliminary toxicity assessment, offering valuable insights for further in vivo or clinical studies. The findings underscore the importance of integrating computational techniques into the safety evaluation of herbal medicines.
Pengaruh Edukasi Terhadap Tingkat Pengetahuan Pengobatan Medis Pada Santri Pondok Pesantren Al-Hikmat Dan Nurul Hikmat Pandeglang Banten Yusransyah, Yusransyah; Lukmanul Hakim, Imam; Kholifah, Eva
JURNAL FARMASI GALENIKA Vol 9 No 2 (2022): Jurnal Farmasi Galenika Vol 9 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v9i2.219

Abstract

Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan santri pondok pesantren Al-Hikmat dan Nurul Hikmat tentang pengobatan medis sebelum dan setelah diberikan edukasi, serta mengetahui adanya pengaruh pemberian edukasi terhadap tingkat pengetahuan pengobatan medis pada santri pondok pesantren Al-Hikmat dan Nurul Hikmat. Manfaat penelitian ini dapat memberikan gambaran melalui data penelitian yang diperoleh tentang pengaruh pemberian edukasi terhadap peningkatan pengetahuan pengobatan medis pada santri pondok pesantren Al-Hikmat dan Nurul Hikmat. Penelitian ini diharapkan mampu meningkatkan pengetahuan santri pondok pesantren Al-Hikmat dan Nurul Hikmat dalam pengobatan medis. Metode penelitian Pre-Experimental Designs dengan teknik pengumpulan data pretest dan posttest pada santri di pondok pesantren Al-Hikmat dan Nurul Hikmat. Data hasil penelitian di analisis menggunakan program SPSS (kolmogorov-smirnov two sample test dan paired samples t-test). Hasil penelitian menunjukan bahwa tingkat pengetahuan santri bertambah setelah diberikan edukasi. Hal ini dibuktikan dengan hasil uji statistik t-test berpasangan, yang diperoleh nilai p= 0,000 yang mana nilai tersebut kurang dari 0,05.
PENGARUH EDUKASI TERHADAP PENGETAHUAN DAN SIKAP ORANG TUA PADA KASUS SEDIAAN SIRUP OBAT PENURUN DEMAM DI DUA DESA KABUPATEN TANGERANG Insani, Nurul; Aziya, Hasna; R, Asti Yunia; Kholifah, Eva
Parapemikir : Jurnal Ilmiah Farmasi Vol 13, No 2 (2024): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v13i2.6949

Abstract

Education is an educator's effort to convey knowledge or messages to communities, groups or individuals, from not knowing to knowing. Ethylene glycol and Diethylene glycol are alcohols that have toxic properties that can increase mortality and morbidity when their use exceeds the provisions or limits that have been set. This study aims to determine the level of knowledge and attitudes of parents in Kronjo Village and Bakung Village about the case of fever-reducing syrup preparations as the main factor causing atypical progressive acute renal failure in children after being given education. Cross sectional research design with pretest and posttest data collection techniques on parents in Kronjo Village and Bakung Village. The data were then analyzed using an application called SPSS (Kolmogorov-smirnov two sample test and Wilcoxon Sign Rank Test). The results showed that the level of knowledge and attitude of parents in Kronjo Village and Bakung Village had increased after being given education. This is evidenced by the results of data that has been analyzed using the Wilcoxon Sign Rank Test with a p value of 0.000 ≤ 0.05, which means there is a significant difference.  
Antioxidant Activity and Vitamin C Concentration Analysis of Gandaria (Bouae macrophylla Griff) Ethanol Extract Using Spectrophotometry UV Vis Kholifah, Eva; Nurazizah, Dewi; Noviyanto, Fajrin
Journal of Fundamental and Applied Pharmaceutical Science Vol. 3 No. 2 (2023): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v3i2.15992

Abstract

Antioxidants are chemical compounds that donate one or more electrons to free radicals to inhibit free radical reactions. One of the potential antioxidant sources is gandaria fruit (Bouea Macrophylla Griff). This research aims to determine the antioxidant activity and vitamin C content of the gandaria fruit extract. Gandaria fruit was macerated with ethanol as a solvent. Furthermore, the rotated extract was carried out for the phytochemical screening. The results of the phytochemical screening of the gandaria fruit extract showed a positive of flavonoids, terpenoids, tannins, saponins, and phenolics. The gandaria fruit extract was tested for antioxidants and quantitative analysis of vitamin C levels to obtain IC50 values and vitamin C levels using spectrophotometry UV-Vis at a wavelength of 517nm with vitamin C as a positive control. The results of spectrophotometric measurements revealed that the gandaria fruit extract had an IC50 value of 5.72 g/ml, and vitamin C had an IC50 value of 2.260 g/ml, indicating that the gandaria fruit extract and vitamin C had very strong antioxidants. The value of vitamin C levels was 0.526 mg.
Formulation and Antioxidant Activity Analysis of Jotang Herb (Acmella paniculata) Extract Mask Cream Kholifah, Eva; Fitriani, Via; Shobah, Afifah Nur
Journal of Fundamental and Applied Pharmaceutical Science Vol. 4 No. 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.19341

Abstract

Pollution in the environment can increase the production of reactive oxygen species (ROS), which can reduce the amount of antioxidants in the skin. Antioxidants are compounds that can inhibit oxidation reactions by binding to free radicals and reactive molecules. Herbaceous plant jotang (Acmella paniculata) has secondary metabolites such as flavonoids, alkaloids, tannins, and saponins, which can protect the internal and external organs of the body's cells from damage caused by free radicals on the skin. One of the treatment preparations used for the skin is a cream mask, as the use or application at the final level of skin care can improve cleanliness and health and stimulate and repair skin cells. This study aims to determine a formula that has a good antioxidant value using the DPPH method (2,2-diphenyl-1-pikrilhidrazyl). In this study, preparations were made with 3 formulas, namely Formula I (1% w/w), Formula II (10%w/w), and Formula 0 (Control). Evaluation of physical properties included organoleptic tests, homogeneity tests, spreadability tests, pH tests, viscosity tests, cream-type tests, and antioxidant tests. The result showed that the organoleptic test had a cream mask dosage in the form of semi-solid, distinctive jotang odor, light and dark green, had a homogeneous dosage form, spreadability around 5.1-5.7 with an average pH value of 6, had a good viscosity value and had a type of cream M/A and a high antioxidant value in formula II (10% w/w ) with an IC50 value of 21.959 μg/ml. Based on statistical tests, significant results were obtained of 0.000<p (0.05) so that it can be interpreted that there was a significant difference in each concentration of jotang herb extract to the resulting IC50 value.
Co-Authors Agustin, Siti Ahmaddhani, Surya Alfiyah, Siti Alifia A.T, Mohammad Arifah, Mitsalina Fildzah Aziya, Hasna Baha Udin Cahya Skania, Pratiwi Fajrin Noviyanto, Fajrin Fitriani, Via Kurnia, Nia Marlina Kurniasih, Kholif Sholehah Indra Lukmanul Hakim, Imam Nabillah, Deya Adiby Nur Insani Nur S, Afifah Nurazizah, Dewi R, Asti Yunia Rahmah, Syafira Atika Setiyawati, Eka Ayu Shobah, Afifah Nur Stiani, Sofi Nurmay Widianingrum, Lucia Yusransyah, Yusransyah Zahroh, Siti Lailatu