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All Journal Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Nur Anggreini Dwi Sasangka
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Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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PERBANDINGAN KADAR DAN UJI MUTU FISIK INJEKSI DEXAMETHASONE SODIUM PHOSPHATE SEBELUM DAN SESUDAH MASA KADALUARSA SECARA SPEKTROFOTOMETRI UV-VIS Ruddat Ilaina Rahmah; Nur Anggreini Dwi Sasangka; Dian Marlina
Jurnal Ilmiah Manuntung Vol 9 No 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i2.668

Abstract

Corticosteroids are drugs that contain synthetic steroid hormones. Dexamethasone sodium phosphate injection is a sterile preparation where a sterile preparation when opened will be exposed to air and microorganism in the surrounding environment, so that drug levels and potency will decrease. The use of steroid injection includes the use that is often used in hospitals and makes stock increase, this increase in preparations which often makes expired preparations will increase and become a problem in every hospital. This study aimed to determine the effect of storage at room temperature and refrigerator temperature on the level and physical quality of dexamethasone sodium phosphate injection before and after expiration. This study used dexamethasone sodium phosphate injection before and after expiration. The raw material for dexamethasone sodium phosphate is listed on the COA, 2022. The injection was stored at room temperature (<300C) and refrigerator temperature (2-80C) within 14 days, then organoleptic observation, pH test, and assay were carried out using UV-VIS Spectrophotometry. Quantitative analysis was carried out by comparing the levels of dexamethasone injection before and after the expiration date based on the linear regression chart and the paired sample t-test. The results obtained show that storage at room temperature and refrigerator temperature does not affect organoleptic observations, pH at the levels of dexamethasone sodium phosphate injection before and after expiration. Testing of dexamethasone sodium phosphate injection levels before and after expiration at room temperature storage (<300C) did not have a significant difference, while dexamethasone sodium phosphate injection levels before and after expiration at refrigerator temperature storage (2-80C) had a significant difference.
PENGARUH PEMBERIAN EDUKASI TERHADAP TINGKAT PENGETAHUAN PENGGUNAAN ANTIBIOTIK PADA PASIEN RAWAT JALAN RSUD Dr. MOEWARDI TAHUN 2023 Magdalena Retnoningsih; Jason Merari Peranginangin; Nur Anggreini Dwi Sasangka
Jurnal Ilmiah Manuntung Vol 10 No 1 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i1.779

Abstract

Antibiotics are drugs to fight bacterial infections. Based on the large amount of antibiotic use, WHO states that the amount of irrational antibiotic use is relatively high, causing the risk of increasing resistance. This research was conducted to determine the level of patient knowledge about the use of antibiotics before and after being given education. This research used a pre-experiment design with one group pre-test and post-test with measuring instruments in the form of questionnaires. The number of samples used was 306 respondents, sample data was collected using purposive sampling by providing verbal education and leaflet media. Data analysis to determine the description of respondents based on characteristic criteria uses univariate analysis, to determine the relationship between respondent characteristics and level of knowledge using bivariate analysis, while to determine the influence between the independent variable and the dependent variable using statistical analysis the Wilcoxon difference test. The results of this research show that the level of knowledge at pre-test was 31% with high knowledge, 30.7% with moderate knowledge, 38.2% with low knowledge. In the post-test 99% had high knowledge, 0.7% had medium knowledge, 0.3% had low knowledge. The results obtained were tested using the Wilcoxon test which obtained a significance value of 0.000 < 0.05. From these results it can be concluded that there is an influence of providing education on the level of knowledge of outpatients at Dr. RSUD. Moewardi, and there is a significant relationship between the characteristics of respondents and the level of knowledge, p value <0.05.
Co-Authors Dian Marlina Jason Merari Peranginangin Magdalena Retnoningsih Ruddat Ilaina Rahmah