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UJI AKTIVITAS ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN KETAPANG (Terminalia catappa L) PADA MENCIT PUTIH YANG DIINDUKSI ALOKSAN Jena Hayu Widyasti; Dian Marlina; Avianti Eka Dewi A.P Eka Dewi A.P
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Diabetes mellitus is a chronic disease that caused of decreasing insulin production at Pancreatic β cell or insulin production which not effective. The purpose of this research was proving catappa’s leaves extract (Terminalia catappa L) have an activity to decrease blood glucose levels trough diabetics on effective doses. The prominent goal may achieved was obtaining efficacious natural medicine of anti-diabetes and knowing the effective doses of catappa’s leaves extract (Terminalia catappa L) as anti-diabetes. This Anti-hyperglycemic research is using mice as many as 30 mice. The activity experiment of anti-diabetes was executed to 6 treatment groups, there are Group I (normal control), Group II negative control (alloxan induced 180 mg/kgBW and aquadest), Group III (alloxan induced and catappa’s leaves extract 75 mg/kgBW), Group IV (alloxan induced and catappa’s leaves extract 150 mg / kgBW), Group V (alloxan induced and catappa’s leaves extract 300 mg/kgBW), and Group VI (positive control that given by alloxan induced and glibenclamide 10mg/kgBW). All of the treatment group was given with that treatment for 14 days and were carried measurement of blood glucose levels on days 0, 3, 10, 17. The leaf extract anti-diabetes activities shown by calculating hypoglycemic capacity of each treatment. The result of this research showed that the ethanol extract of catappa’s leaves have anti-hyperglycemic activities on mice that alloxan induced. At the doses of ethanol extract of leaves of catappa 300 mg/kgBW have effectively anti-hyperglycemic activities than doses of 150 mg/kgBW and 75 mg/kgBW that was comparable with positive control group

Variations of Tween Surfactant and Propylene Glycol Cosurfactant in Topical Microemulsion Formulation on The Penetration of Ibuprofen Sri Fitrianingsih; Gunawan Pamudji Widodo; Dian Marlina
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 2 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i2.5785

ABSTRACTIbuprofen is a derivative of propionic acid, a class of non-steroidal anti-inflammatory drugs (NSAIDs). Ibuprofen has side effects on the gastrointestinal tract. So that topical use can be a solution to reduce the side effects of oral use because of the release of topical drugs through the stratum corneum which makes it selective in certain places. The preparation chosen was a topical microemulsion because it is more thermodynamically stable and has no effect on the gastrointestinal tract. This study aims to determine the effect of the ratio of surfactant concentrations of various ratios of tween 20:tween 80 and cosurfactant propylene glycol to the penetration rate of ibuprofen across the membrane and to determine the physical characteristics of topical microemulsions. Selection of tween surfactant and propylene glycol cosurfactant because it has high physical stability. This research is an experimental study, namely by making four formulations with various ratios of surfactant and cosurfactant with a difference of 2.5% in each formulation of topical ibuprofen microemulsion with a concentration of 5% ibuprofen using variations of surfactant tween 20 and tween 80, cosurfactant propylene glycol with black cumin oil phase. Evaluation of the preparation by organoleptic test, pH test of the preparation, examination of the type of emulsion, particle size measurement, microemulsion release test in vitro using the Franz diffusion method. The results show that the concentration ratio of surfactant tween 20:tween 80 and cosurfactant propylene glycol can affect particle size, pH and penetration velocity (flux) in Franz diffusion. The results of the study showed that in F1 using surfactant tween 20:tween 80 with a concentration of 71.6% (6:4) had the smallest particle size of 11.5 nm and the largest flux value was 128.45 g.cm-2.H- 1. In conclusion, variations in surfactant and cosurfactant concentrations can affect the pH of the preparation, particle size, penetration speed (flux). The results obtained that the cumulative percent and penetration speed of all formulas had significant differences (p0.05).

PERAN MEDIA PAPAN PERKALIAN PINTAR (PAPERPI) TERHADAP KETERAMPILAN BELAJAR MATEMATIKA SISWA DI SDN 01 MANISREJO Tia Tri Kuswanti; Fauzatul Ma’rufah; Dian Marlina
SEMINAR NASIONAL SOSIAL, SAINS, PENDIDIKAN, HUMANIORA (SENASSDRA) Vol 2, No 2 (2023): Implementasi kurikulum merdeka menuju transformasi pendidikan dalam mempersiapka
Publisher : SEMINAR NASIONAL SOSIAL, SAINS, PENDIDIKAN, HUMANIORA (SENASSDRA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Penelitian ini merupakan penelitian kuantitatif dengan model the nonequivalent pretest-posttest control. Yang melatarbelakangi penelitian ini adalah siswa kelas 2 merasa kesulitan dan belum memahami materi perkalian, selain itu guru tidak kreatif dalam penggunaan media dan kemampuandalam penyusunan media belajar belum memadai. Tujuan Penelitian ini untuk mengetahui pengaruh hasil belajar matematika antara siswa kelas 2 SDN 01 Manisrejo yang belajar menggunakan media papan perkalian pintar terhadap siswa yang mendapatkan pembelajaran konvensional dengan menggunakan metode eksperimen semu. Pada penelitian ini teknik pengumpulan data yang digunakan adalah tes serta dokumentasi, sedangkan teknik untuk menganalisis data menggunakan metode deskriptif dan uji prasyarat hipotesis. Hasil penelitian membuktikan bahwa posttest siswa kelas eksperimen dan kelas control adalah (3,10 ≥ 2,01), yang berarti (H2) diterima sedangkan (H0) ditolak. Dengan demikian penulis menyimpulkan bahwa terdapat pengaruh penggunaan media papan cerdas perkalian untuk hasil belajar matematika siswa kelas 2 di SDN 01 MANISREJO.

PERBANDINGAN KADAR DAN UJI MUTU FISIK INJEKSI DEXAMETHASONE SODIUM PHOSPHATE SEBELUM DAN SESUDAH MASA KADALUARSA SECARA SPEKTROFOTOMETRI UV-VIS Ruddat Ilaina Rahmah; Nur Anggreini Dwi Sasangka; Dian Marlina
Jurnal Ilmiah Manuntung Vol 9 No 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i2.668

Corticosteroids are drugs that contain synthetic steroid hormones. Dexamethasone sodium phosphate injection is a sterile preparation where a sterile preparation when opened will be exposed to air and microorganism in the surrounding environment, so that drug levels and potency will decrease. The use of steroid injection includes the use that is often used in hospitals and makes stock increase, this increase in preparations which often makes expired preparations will increase and become a problem in every hospital. This study aimed to determine the effect of storage at room temperature and refrigerator temperature on the level and physical quality of dexamethasone sodium phosphate injection before and after expiration. This study used dexamethasone sodium phosphate injection before and after expiration. The raw material for dexamethasone sodium phosphate is listed on the COA, 2022. The injection was stored at room temperature (<300C) and refrigerator temperature (2-80C) within 14 days, then organoleptic observation, pH test, and assay were carried out using UV-VIS Spectrophotometry. Quantitative analysis was carried out by comparing the levels of dexamethasone injection before and after the expiration date based on the linear regression chart and the paired sample t-test. The results obtained show that storage at room temperature and refrigerator temperature does not affect organoleptic observations, pH at the levels of dexamethasone sodium phosphate injection before and after expiration. Testing of dexamethasone sodium phosphate injection levels before and after expiration at room temperature storage (<300C) did not have a significant difference, while dexamethasone sodium phosphate injection levels before and after expiration at refrigerator temperature storage (2-80C) had a significant difference.

Sustainable Digital Transformation in Healthcare: Challenges and Directions in the Society 5.0 Era Kusumo, Haryo; Dian Marlina; Achmad Solechan
Advance Sustainable Science Engineering and Technology Vol. 7 No. 1 (2025): November-January
Publisher : Science and Technology Research Centre Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v6i4.876

This study conducts a comprehensive literature review on the digital transformation required by health service institutions during the Society 5.0 era. Utilizing articles related to digital transformation and health services, the study presents qualitative data simplified into descriptive narratives to draw meaningful conclusions. The method employed is a qualitative literature review. The review identifies significant challenges, including big data utilization, data security, privacy concerns, and the implementation of cloud computing systems. Furthermore, the research synthesizes current trends and proposes actionable recommendations for overcoming these challenges, such as adopting Health 5.0 and fostering integrated Community 5.0 systems. The study underscores the importance of maintaining the human aspect amidst technological advancements. Future research directions are outlined, focusing on the "big data-based society" within Society 5.0 to explore innovative solutions, mitigate barriers, and ensure sustainable digital transformation in healthcare services.

Pengaruh Pengungkapan Emisi Karbon, Kinerja Perusahaan, Eco-Efficciency terhadap Nilai Perusahaan Dimoderasi Kinerja Lingkungan Dian Marlina; Vinola Herawaty
El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam Vol. 5 No. 8 (2024): El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/elmal.v5i8.3681

The purpose of this researcher is to test and analyze the effect of carbon emissions, Company performance, eco-efficiency on the value of enterprise moderated environmental performance. This research uses companies in the consumer non-cyclic and basic materials sectors listed on the Indonesia Stock Exchange from 2021 to 2023. There are 42 companies that fit the criteria using the purposive sampling method. Analysis of data used by multiple regression analysis Collection of data from financial statements, annual reports and sustainability reports from individual companies. The results of this study show that the disclosure of carbon emissions negatively affects the value of the Company. Corporate performance and eco-efficiency have a positive effect on corporate value. Environmental performance is unable to moderate the effect of carbon emissions disclosure and eco-efficiency on corporate value. Environmental performance can moderate the effect that corporate performance has on corporate value.

Characterization of microencapsulated Saga Leaves Extract (Abrus precatorius L.) and Analgetic Activity Tests in Male Mice (Mus musculus) Jehan, Nabilah Nauli; Titik Sunarni; Dian Marlina
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.280-289

Background: Saga leaves are one of the plants that have analgesic activity. Saga leaves contain phenol compounds, flavonoids, tannins, alkaloids, and saponins. Phenol has instability with oxygen, light, and high temperatures. Therefore, the microencapsulation process is necessary. Microcapsule characterization in this study included encapsulation efficiency, particle size, distribution value and morphology. Objective: This research was to determine the characterization of microcapsules and the analgesic activity of saga leaf extract microcapsules in male mice. Methods: The microencapsulation process conducted in this study was carried out using the spray drying method. Saga leaf extract was coated with the coating material in the ratio of 1:20. Several ratios of maltodextrin (MD) and soy protein isolate (SPI) (100%:0%); (75%%:25); (50%:50%); (25%:75%) were applied as the coating material. The encapsulation efficiency was determined by comparing the total phenol content of the extract and microcapsule. Particle size and distribution values were tested using a particle size analyzer. Microcapsule morphology was seen using scanning electron microscopy. Analgesic activity test using the tail-flick method with mice as test animals. Data analysis in this study used one-way ANOVA. Results: The encapsulation efficiency obtained was 31.40-80.29%. The particle size obtained in the microcosm was 17.70-30.90 µm. The distribution value obtained was 1.42-2.45. The morphology of the microcapsule obtained was round and had wrinkles. The analgesic activity obtained in this study resulted in significantly different pain inhibition values before and after microencapsulation. Conclusion: The characteristics of microcapsule preparations are well-known, and the analgesic activity of various microcapsules was 42.43-57.15%.

Pengaruh Pengungkapan Emisi Karbon, Kinerja Perusahaan, Eco-Efficciency terhadap Nilai Perusahaan Dimoderasi Kinerja Lingkungan Dian Marlina; Vinola Herawaty
El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam Vol. 5 No. 8 (2024): El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/elmal.v5i8.3681

The purpose of this researcher is to test and analyze the effect of carbon emissions, Company performance, eco-efficiency on the value of enterprise moderated environmental performance. This research uses companies in the consumer non-cyclic and basic materials sectors listed on the Indonesia Stock Exchange from 2021 to 2023. There are 42 companies that fit the criteria using the purposive sampling method. Analysis of data used by multiple regression analysis Collection of data from financial statements, annual reports and sustainability reports from individual companies. The results of this study show that the disclosure of carbon emissions negatively affects the value of the Company. Corporate performance and eco-efficiency have a positive effect on corporate value. Environmental performance is unable to moderate the effect of carbon emissions disclosure and eco-efficiency on corporate value. Environmental performance can moderate the effect that corporate performance has on corporate value.

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