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All Journal Heart Science Journal Caring : Jurnal Pengabdian Masyarakat
Cesarius Singgih Wahono
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Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Association of clinical manifestations, disease activity, and medications on premature atherosclerosis in systemic lupus erythematosus Pratama, Mirza Zaka; Kusworini Handono; Cesarius Singgih Wahono; Ahmad Bayhaqi Nasir Aslam; Syahrul Chilmi
Heart Science Journal Vol. 6 No. 1 (2025): Challenges in Managing Acute Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.01.11

Abstract

Background SLE is distinguished by the development of multiple autoantibodies that lead to chronic inflammation and increased risk of cardiovascular diseases, especially atherosclerosis. Objective This examination sought to explore the association between the disease activity, clinical manifestations, and medication with the atherosclerotic lesion from SLE patients. Methods This inquiry investigated forty-two female SLE patients (18-45 years old) who met the 2019 EULAR/ACR assortment decency with matched healthy individuals as control A cross-sectional study was sanctioned at the Rheumatology Clinic of Saiful Anwar General Hospital Malang between July and November 2023. Demographic data, clinical manifestations, and medication history was documented in the medical records. Disease activity was stelled by the SLEDAI-2K score. Carotid Intima-Media Thickness (cIMT) and Flow-Mediated Dilation (FMD) (after brachial BP cuff inflation up to 200 mmHg for five minutes) examinations were used as atherosclerosis marker. Results Markedly higher of cIMT mean was demonstrated in SLE patients compared to healthy individual (0.51±0.11 vs 0.40±0.11 mm, p<0.001). FMD was subtancially curtailed in SLE patients set side to side to control (0.00 (0.00-0.10) vs 0.10 (0.00-0.28) mm, p=0.022). There was no statistical distinctness of the cIMT and FMD among SLE patients according to the presence of clinical manifestations. Neither cIMT nor FMD showed a statistically correlated with the disease activity. Patients who received hydroxychloroquine (0.57±0.02 vs. 0.50±0.09 mm, p=0.043) and cyclophosphamide (0.55±0.09 vs. 0.48 ± 0.10 mm, p=0.031) had higher cIMT. Higher cIMT was demonstrated in subjects who received steroid (p=0.045) and the dosage of steroid was essentially enforced to cIMT (R=0.418, p=0.034). Conclusion Our study unveil that early atherosclerosis was evidenced in patients with SLE and several medications might affect the progressivity of atherosclerosis.
Association of clinical manifestations, disease activity, and medications on premature atherosclerosis in systemic lupus erythematosus Pratama, Mirza Zaka; Kusworini Handono; Cesarius Singgih Wahono; Ahmad Bayhaqi Nasir Aslam; Syahrul Chilmi
Heart Science Journal Vol. 6 No. 1 (2025): Challenges in Managing Acute Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.01.11

Abstract

Background SLE is distinguished by the development of multiple autoantibodies that lead to chronic inflammation and increased risk of cardiovascular diseases, especially atherosclerosis. Objective This examination sought to explore the association between the disease activity, clinical manifestations, and medication with the atherosclerotic lesion from SLE patients. Methods This inquiry investigated forty-two female SLE patients (18-45 years old) who met the 2019 EULAR/ACR assortment decency with matched healthy individuals as control A cross-sectional study was sanctioned at the Rheumatology Clinic of Saiful Anwar General Hospital Malang between July and November 2023. Demographic data, clinical manifestations, and medication history was documented in the medical records. Disease activity was stelled by the SLEDAI-2K score. Carotid Intima-Media Thickness (cIMT) and Flow-Mediated Dilation (FMD) (after brachial BP cuff inflation up to 200 mmHg for five minutes) examinations were used as atherosclerosis marker. Results Markedly higher of cIMT mean was demonstrated in SLE patients compared to healthy individual (0.51±0.11 vs 0.40±0.11 mm, p<0.001). FMD was subtancially curtailed in SLE patients set side to side to control (0.00 (0.00-0.10) vs 0.10 (0.00-0.28) mm, p=0.022). There was no statistical distinctness of the cIMT and FMD among SLE patients according to the presence of clinical manifestations. Neither cIMT nor FMD showed a statistically correlated with the disease activity. Patients who received hydroxychloroquine (0.57±0.02 vs. 0.50±0.09 mm, p=0.043) and cyclophosphamide (0.55±0.09 vs. 0.48 ± 0.10 mm, p=0.031) had higher cIMT. Higher cIMT was demonstrated in subjects who received steroid (p=0.045) and the dosage of steroid was essentially enforced to cIMT (R=0.418, p=0.034). Conclusion Our study unveil that early atherosclerosis was evidenced in patients with SLE and several medications might affect the progressivity of atherosclerosis.
UB Integrated Door-To-Door Health Clinic Model for Community Health Literacy And Cadre Empowerment Dewi, Elvira Sari; Nurul Evi; Tri Yudani Mardining Raras; Linda Wieke Noviyanti; Muhammad Mumtaz Firdausi; Revania Angelina Putria Sidhikhoh; Navia Irfani Nabila; Achmad Andre Maulana; Restu Aisyah Rohma; Aufa Humayra Putrikami; Untari; Arfandeon Darrel Selva Reksa Priyanggada; Imam Wahyu Indrawan; Intan Yusuf Habibie; Cesarius Singgih Wahono; Nur Salim
Caring: Jurnal Pengabdian Masyarakat Vol. 6 No. 1 (2026): CARING Jurnal Pengabdian Masyarakat (April 2026) In Press
Publisher : Department of Nursing, Faculty of Health Sciences, Universitas Brawijaya.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Low community health literacy and limited local health cadre capacity remain major public health challenges in peri-urban areas of Malang, Indonesia. To address these issues, Universitas Brawijaya (UB) developed the UB Integrated Door-to-Door Health Clinic Model, combining health education, basic medical services, and cadre empowerment through household-based outreach. This study evaluated the model’s effectiveness in improving community health literacy and cadre capacity in Kalirejo Village. The program involved lecturers, students, healthcare professionals, and local cadres through health education, screening, counseling, and training activities. Quantitative data were analyzed using descriptive statistics and paired comparative tests, while qualitative feedback was analyzed thematically. Results showed significant improvements in community health literacy mean scores (62.4% to 81.7%; p<0.05) and cadre competency scores (58.9% to 84.3%; p<0.05). Participants also reported increased engagement in health promotion activities. The model demonstrates the potential of university-led integrated outreach programs for sustainable community empowerment and health promotion.
Co-Authors Achmad Andre Maulana Ahmad Bayhaqi Nasir Aslam Arfandeon Darrel Selva Reksa Priyanggada Aufa Humayra Putrikami Elvira Sari Dewi Imam Wahyu Indrawan Intan Yusuf Habibie Kusworini Handono Linda Wieke Noviyanti Muhammad Mumtaz Firdausi Navia Irfani Nabila Nur Salim Nurul Evi Pratama, Mirza Zaka Restu Aisyah Rohma Revania Angelina Putria Sidhikhoh Syahrul Chilmi Tri Yudani Mardining Raras Untari