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All Journal Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Integrasi Kesehatan dan Sains Jurnal Riset Kedokteran
Budiarti, Indri
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Humanities Dentistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Review Article: Peran Reactive Oxygen Species pada Patogenesis Preeklamsia Kurniasari, Febriana Kurniasari; Effendi, Jusuf Sulaeman; Budiarti, Indri
Jurnal Integrasi Kesehatan dan Sains Vol 7, No 1 (2025): Jurnal Integrasi Kesehatan dan Sains (in progress)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v7i1.14514

Abstract

Preeklamsia merupakan penyakit multifaktorial pada kehamilan yang ditandai dengan onset baru hipertensi pada kehamilan dengan atau tanpa proteinuria atau kegagalan organ pada usia gestasi lebih dari 20 minggu. Preeklamsia merupakan salah satu penyebab morbiditas dan mortalitas yang memengaruhi 3–7% kehamilan di seluruh dunia. Patogenesis preeklamsia berkaitan dengan abnormalitas plasentasi akibat defek pada invasi trofoblas dan gangguan remodeling arteri spiralis pada uterus sehingga menyebabkan sirkulasi uteroplasenta yang buruk. Penelitian ini bertujuan mendeskripsikan peran reactive oxygen species (ROS) pada patogenesis preeklamsia. Penelitian ini menggunakan metode kepustakaan literature review dengan mengumpulkan beberapa hasil penelitian, yaitu berupa artikel yang kredibel dan lengkap seperti GoogleScholar, ScienceDirect, dan PubMed dengan kata kunci preeklamsia, reactive oxygen species, dan antioksidan. Assessment dilaksanakan berdasarkan kelayakan terhadap kriteria inklusi dan eksklusi didapatkan sebanyak 14 artikel yang digunakan dalam literature review ini. Dari 14 penelitian didapatkan 5 artikel ilmiah yang dijadikan sebagai acuan utama untuk diteliti pada literture review. Dari 5 penelitian tersebut menunjukkan bahwa ROS diperlukan pada awal kehamilan untuk proses angiogenesis dan proliferasi serta pematangan sel yang diperlukan untuk pemeliharaan kehamilan dan perkembangan embrio. Namun, peningkatan level ROS pada kehamilan lanjut dapat menyebabkan kondisi patologis. Simpulan pada penelitian ini adalah stres oksidatif merupakan penyebab utama pelepasan sitokin dan faktor antiangiogenik ke sirkulasi maternal sehingga menyebabkan disfungsi endotel dan inflamasi bersamaan dengan penurunan bioavaibilitas nitrit oksida (NO) dan disfungsi aktivitas endothelial nitric oxide synthase (eNOS) di plasenta. Review Article: The Role of Reactive Oxygen Species in the Pathogenesis of PreeclampsiaAbstractPreeclampsia is a multifactorial disease in pregnancy characterized by a new onset of gestational hypertension with or without proteinuria or end-organ failure after the 20th week of pregnancy. Preeclampsia is a leading cause of morbidity and mortality that affects 3-7% of pregnancies worldwide. The pathogenesis of preeclampsia is related to abnormal placentation due to trophoblast invasion and spiral artery remodeling disorder in the uterus, thus causing poor circulation of the uteroplacental. This study aims to describe the role of ROS in the pathogenesis of preeclampsia. This research uses the literature review method by collecting several research results, namely in the form of credible and complete articles such as Google Scholar, ScienceDirect, and PubMed, with keywords preeclampsia, reactive oxygen species, and antioxidants. The assessment was based on the suitability of the inclusion and exclusion criteria for 14 articles used in this literature review. From 14 studies, five scientific articles were obtained, which were used as the primary reference for research in the literature review. These five studies show that ROS are needed in early pregnancy for the processes of angiogenesis and proliferation and cell requirements required for pregnancy maintenance and embryo development. However, increased ROS levels in late pregnancy can cause pathological conditions. This study concludes that oxidative stress is the leading cause of the release of cytokines and antiangiogenic factors into the maternal circulation, causing endothelial dysfunction and inflammation along with decreased nitric oxide (NO) bioavailability and dysfunction of endothelial nitric oxide synthase (eNOS) activity in the placenta.
Reproductive health education and early sexual behavior prevention assistance for Madrasah Aliyah students in Bandung Widiyastuti, Ermina; Damayanti, Meta Maulida; Nur, Ismet Muchtar; Siddiq, Tita Barriah; Budiarti, Indri; Prasetia, Ayu
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol. 9 No. 2 (2024): May 2024
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v9i2.12361

Abstract

Health reproduction knowledge is a crucial factor in preventing acts of early sexual behavior. Early sexual behavior is reflected in many ways, from attraction to different sexes to building a relationship and making physical contact. Adequate knowledge of sexuality in teenagers especially in health reproduction would prevent teenagers from acting in early sexual behavior. This activity aims to increase knowledge about the health of reproductive organs and the prevention of early sexual intercourse among Madrasah Aliyah students. The method used is education regarding the health of reproductive organs, pre-marital sexual psychology, and social jurisprudence approaches. All material is presented interestingly and interactively. This activity found that 63 percent of the participants had previous knowledge of this topic. More than 50 percent of respondents were students, and students had quite good knowledge about reproductive health. Madrasah Aliyah students already have sufficient knowledge about reproductive health, but it has not yet been seen whether it is enough to prevent students from premature sexual behavior. However, we do not have any data regarding the act of early sexual behavior among respondents or how knowledge in health reproduction would relate to the act of early sexual behavior.
Hubungan Index Massa Tubuh dengan Siklus Menstruasi dan Acne Vulgaris Aulia, Vadila; Sulaeman, Jusuf; Budiarti, Indri
Jurnal Riset Kedokteran Volume 5, No.2, Desember 2025, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrk.v5i2.8389

Abstract

Abstract. Kesehatan reproduksi perempuan, terutama menstruasi dan acne vulgaris, menjadi isu penting pada masa remaja dan dewasa awal. Indeks Massa Tubuh (IMT) diduga memengaruhi keteraturan menstruasi dan kejadian acne vulgaris melalui mekanisme hormonal. Penelitian ini bertujuan menganalisis hubungan IMT dengan siklus menstruasi dan acne vulgaris pada mahasiswi Fakultas Kedokteran Universitas Islam Bandung. Desain penelitian menggunakan cross-sectional dengan 115 responden yang dipilih melalui stratified random sampling. IMT dikategorikan menjadi underweight, normal, dan overweight/obesitas, sedangkan siklus menstruasi diklasifikasikan sebagai teratur atau tidak teratur. Analisis menggunakan uji chi-square dan multivariat. Hasil menunjukkan sebagian besar mahasiswi memiliki IMT normal (61,7%), siklus teratur (71,3%), dan mengalami acne vulgaris (79,1%). Terdapat hubungan signifikan antara IMT dan keteraturan siklus menstruasi (p = 0,001), dengan kelompok overweight menunjukkan risiko siklus tidak teratur tertinggi (85,7%). Tidak ditemukan hubungan signifikan antara IMT dan acne vulgaris (p = 0,358). IMT menjelaskan 35,9% variasi siklus menstruasi, namun hanya 1,8% variasi acne vulgaris. Kesimpulannya, IMT berhubungan dengan keteraturan menstruasi, tetapi tidak dengan acne vulgaris yang lebih dipengaruhi faktor hormonal, genetik, dan lingkungan. Abstrak. Women’s reproductive health, particularly menstruation and acne vulgaris, is essential during adolescence and early adulthood. Body Mass Index (BMI) may influence menstrual cycle regularity and acne vulgaris through hormonal pathways. This study analyzed the relationship between BMI, menstrual cycle regularity, and acne vulgaris among female students at the Faculty of Medicine, Islamic University of Bandung. A cross-sectional design was used involving 115 students selected through stratified random sampling. BMI was classified into underweight, normal, and overweight/obesity, while menstrual cycles were categorized as regular or irregular. Data were analyzed using chi-square and multivariate tests. Most respondents had normal BMI (61.7%), regular cycles (71.3%), and experienced acne vulgaris (79.1%). A significant association was found between BMI and menstrual cycle regularity (p = 0.001), with the overweight group showing the highest risk of irregular cycles (85.7%). No significant association was found between BMI and acne vulgaris (p = 0.358). BMI explained 35.9% of menstrual cycle variation but only 1.8% of acne vulgaris occurrence. In conclusion, BMI is associated with menstrual cycle regularity but not with acne vulgaris, which is more strongly influenced by hormonal, genetic, and environmental factors.
Co-Authors Aulia, Vadila Ismet Muchtar Nur Jusuf Sulaeman Effendi Kurniasari, Febriana Kurniasari Meta Maulida Damayanti Prasetia, Ayu Siddiq, Tita Barriah Sulaeman, Jusuf Widiyastuti, Ermina