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All Journal Althea Medical Journal Global Medical and Health Communication Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Integrasi Kesehatan dan Sains Jurnal Riset Kedokteran Bandung Conference Series : Medical Science
Ismet Muchtar Nur
Fakultas Kedokteran, Universitas Islam Bandung
Humanities Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Solanumnigrum L. as a Hepatoprotective Agent Rizky, Muthiana; Sastramihardja, Herri S.; Nur, Ismet Muchtar
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1296.501 KB)

Abstract

  Background: Liver damage may be caused by various factors. SolanumnigrumL.fruit is known to contain flavonoid antioxidant which is responsible for its hepatoprotective effect. A study was conducted to determine the protective effect of Solanumnigrum L. fruit infusion (SNFI) on CCl4-induced hepatic cell damage in rats. Methods: A complete randomized experimental study was conducted on 25 male Wistar strain-white rats (Rattusnorvegicus) which were divided into five groups during the period of September– October 2012. Group I (negative control) was given standardized food and water; group II (positive control) was induced by carbon tetrachloride (CCl4) 10% paraffin intraperitoneally by 8 mL/kg body weight on the 8th day of the study; group III, IV, V (treated) were given Solanumnigrum L. fruit infusion (SNFI) by 22.5g/100mL, 45 g/100mL and 90g/100mL concentrations for 8 days, respectively, prior to CCl4 induction. The calculation of necrotic liver cells was performed in 48 hours after induction. Data were statistically analyzed using Kruskal-Wallis test followed by Mann-Whitney post-hoc test. Results: The percentage of necrosis liver cells in group III, IV, and V was smaller compared to  the positive control group. The protective effect of SNFI against CCl4-induced hepatotoxicity may be related to its ability to elevate the antioxidant agent in the body. There were significant differences in necrotic between Group II and group III, IV, V which were treated with SNFI. Conclusion: Further investigation is required to characterize the active ingredients and the mechanism of SNF action to confirm the hepatoprotective and antioxidant effects.Keywords: CCl4, hepatoprotective, Solanumnigrum L.DOI: 10.15850/amj.v2n1.433  
Clinical and Histopathological Characteristic of Salivary Gland Carcinoma in Dr. Hasan Sadikin General Hospital in 2009–2012 Andriani, Fatimah Lidya; Nur, Ismet Muchtar; Mahdiani, Sally
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (529.612 KB)

Abstract

Background: Salivary gland neoplasm is one of the rare neoplasm. The frequency of this neoplasm is lower than 2% of all type of tumors in human. Malignant salivary gland tumor comprises 6% of all head and neck tumors. Data about salivary gland carcinoma are still limited. The aim of this study was to determine the frequency of malignant salivary gland based on the patients’ age, gender, site of lesion and histopathology type. Methods: This study was conducted descriptively. There were 97 subjects found from histopathological form that had been examined in Department of Anatomical Pathology, Dr. Hasan Sadikin General Hospital in 2009–2012. Total sampling technique was used and all data about patients’ age, gender, site of lesion and histopathology type were collected and analyzed.Results: Of 97 cases, age group 50–59 years old had the highest frequency (29%). The prevalence in male was more frequent than female with male:female ratio was 1.4:1. The most common site of carcinoma was found in parotid gland (45%). Mucoepidermoid carcinoma was the most common histopathology type found in this study (28%).Conclusions: Salivary gland carcinoma is still a rare malignant case in Dr. Hasan Sadikin General Hospital. Carcinoma in parotid gland was the most common site and mucoepidermoid carcinoma was the most common histopathology type. [AMJ.2016;3(1):54–8]DOI: 10.15850/amj.v3n1.696
Solanumnigrum L. as a Hepatoprotective Agent Muthiana Rizky; Herri S. Sastramihardja; Ismet Muchtar Nur
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1296.501 KB)

Abstract

  Background: Liver damage may be caused by various factors. SolanumnigrumL.fruit is known to contain flavonoid antioxidant which is responsible for its hepatoprotective effect. A study was conducted to determine the protective effect of Solanumnigrum L. fruit infusion (SNFI) on CCl4-induced hepatic cell damage in rats. Methods: A complete randomized experimental study was conducted on 25 male Wistar strain-white rats (Rattusnorvegicus) which were divided into five groups during the period of September– October 2012. Group I (negative control) was given standardized food and water; group II (positive control) was induced by carbon tetrachloride (CCl4) 10% paraffin intraperitoneally by 8 mL/kg body weight on the 8th day of the study; group III, IV, V (treated) were given Solanumnigrum L. fruit infusion (SNFI) by 22.5g/100mL, 45 g/100mL and 90g/100mL concentrations for 8 days, respectively, prior to CCl4 induction. The calculation of necrotic liver cells was performed in 48 hours after induction. Data were statistically analyzed using Kruskal-Wallis test followed by Mann-Whitney post-hoc test. Results: The percentage of necrosis liver cells in group III, IV, and V was smaller compared to  the positive control group. The protective effect of SNFI against CCl4-induced hepatotoxicity may be related to its ability to elevate the antioxidant agent in the body. There were significant differences in necrotic between Group II and group III, IV, V which were treated with SNFI. Conclusion: Further investigation is required to characterize the active ingredients and the mechanism of SNF action to confirm the hepatoprotective and antioxidant effects.Keywords: CCl4, hepatoprotective, Solanumnigrum L.DOI: 10.15850/amj.v2n1.433  
Clinical and Histopathological Characteristic of Salivary Gland Carcinoma in Dr. Hasan Sadikin General Hospital in 2009–2012 Fatimah Lidya Andriani; Ismet Muchtar Nur; Sally Mahdiani
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (529.612 KB)

Abstract

Background: Salivary gland neoplasm is one of the rare neoplasm. The frequency of this neoplasm is lower than 2% of all type of tumors in human. Malignant salivary gland tumor comprises 6% of all head and neck tumors. Data about salivary gland carcinoma are still limited. The aim of this study was to determine the frequency of malignant salivary gland based on the patients’ age, gender, site of lesion and histopathology type. Methods: This study was conducted descriptively. There were 97 subjects found from histopathological form that had been examined in Department of Anatomical Pathology, Dr. Hasan Sadikin General Hospital in 2009–2012. Total sampling technique was used and all data about patients’ age, gender, site of lesion and histopathology type were collected and analyzed.Results: Of 97 cases, age group 50–59 years old had the highest frequency (29%). The prevalence in male was more frequent than female with male:female ratio was 1.4:1. The most common site of carcinoma was found in parotid gland (45%). Mucoepidermoid carcinoma was the most common histopathology type found in this study (28%).Conclusions: Salivary gland carcinoma is still a rare malignant case in Dr. Hasan Sadikin General Hospital. Carcinoma in parotid gland was the most common site and mucoepidermoid carcinoma was the most common histopathology type. [AMJ.2016;3(1):54–8]DOI: 10.15850/amj.v3n1.696
Perbandingan Faktor Risiko Pasien Limfadenitis Tuberkulosis antara Hasil Bakteri Tahan Asam Positif dan Negatif Naufal Fadhillah Alam; Meta Maulida Damayanti; Maya Tejasari; Ismet Muchtar Nur; Yani Triyani
Jurnal Integrasi Kesehatan dan Sains Vol 2, No 1 (2020): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v2i1.4347

Abstract

Limfadenitis tuberkulosis merupakan tuberkulosis ekstraparu (TEBP) yang paling umum di dunia. Diagnosis pasti TEBP ditegakkan dengan pemeriksaan klinis, bakteriologis, dan atau histopatologis contoh uji yang diambil dari organ tubuh yang terkena. Pemeriksaan BTA dengan Ziehl Neelsen langsung pada jaringan mempunyai sensitivitas rendah sehingga jarang dilakukan. Penelitian ini bertujuan menganalisis perbandingan faktor risiko limfadenitis tuberkulosis dengan hasil BTA positif dan negatif dari jaringan KGB berdasar atas usia, jenis kelamin, dan riwayat TB paru di Laboratorium Rumah Sakit Al-Islam Bandung tahun 2016–2017. Terdapat 18 pasien dengan hasil BTA positif dan 17 pasien dengan BTA negatif yang memenuhi kriteria inklusi. Penelitian ini menggunakan desain penelitian potong lintang dengan analisis data univariat untuk mengetahui gambaran faktor risiko pasien dan bivariat untuk melihat hasil perbandingan faktor risiko pasien. Hasil penelitian ini menunjukkan pasien dengan BTA positif banyak diderita oleh pasien usia <20 tahun (8 dari 18) dan BTA negatif 30–39 tahun (6 dari 17). Pasien wanita mendominasi BTA positif (15 dari 18) dan BTA negatif (11 dari 17) daripada laki-laki. Pasien yang tidak mempunyai riwayat TB paru mendominasi BTA positif (14 dari 18) dan BTA negatif (14 dari 17). Perbandingan faktor risiko pasien antara hasil BTA positif dan negatif berdasar atas usia (p=0,117), jenis kelamin (p=0,264), dan riwayat TB paru (p=1,000). Walaupun mempunyai sensitivitas yang rendah, pemeriksaan BTA jaringan harus dilakukan guna memberikan informasi yang maksimal untuk klinisi. Simpulan, perbandingan faktor risiko limfadenitis tuberkulosis antara hasil BTA positif tidak berbeda. COMPARASION OF LYMPHADENITIS TUBERCULOSIS PATIENT’S RISK FACTOR BETWEEN POSITIVE AND NEGATIVE ACID-FAST BACILLUS Lymphadenitis tuberculosis is most common extrapulmonary tuberculosis (EPTB) in the world. Definitive diagnosis in EPTB is by clinical examination, bacterial examination, and histopatological examination from sample in affected organ. AFB examination by Ziehl Neelsen directly from tissue has low sensitivity and high specificity. This study aims to examine the comparion of lymphadenitis tuberculosis patient’s risk factor between positive and negative AFB from lymph node tissue based on age, sex, and previous history of pulmonary tuberculosis in Laboratory of Al-Islam Hospital Bandung during 2016–2017. There were 18 patients with positive AFB and 17 patients with negative AFB who met inclusion criteria. This study used cross sectional design with univariate data analysis to descript the risk factor of patients and bivariate to see the comparison of patient characteristics. The result of this study showed patient with positive AFB occur more at the age of <20 (8 of 18) and negative AFB occur more at the age of 30–39 (6 of 17). Woman were dominated positive AFB (15 of 18) and negative AFB (11 of 17) than man. Patients with no previous pulmonary tuberculosis history were dominated positive AFB (14 of 18) and negative AFB (14 of 17). Comparison of lymphadenitis tuberculosis patient’s risk factor between positive and negative AFB based on age (p=0.117), sex (p=0.264), and previous history of pulmonary tuberculosis (p=1.000). Despite low sensitivity, tissue AFB examination should be performed to give maximal information for clinician. Conclusion, comparison of lymphadenitis tuberculosis risk factor between positive and negative AFB is not different.
Karakteristik Nevus Pigmentosus berdasar atas Gambaran Histopatologi di Rumah Sakit Al-Islam Bandung Ennok Nisa Islamiati; Siska Nia Irasanti; Mia Kusmiati; Deis Hikmawati; Ismet Muchtar Nur
Jurnal Integrasi Kesehatan dan Sains Vol 1, No 1 (2019): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v1i1.4327

Abstract

Nevus pigmentosus (NP) merupakan lesi melanositik jinak yang paling umum, puncaknya pada usia 25 sampai 26 tahun. Faktor yang memengaruhinya di antaranya penuaan, pubertas, kehamilan, penggunaan kortikosteroid sistemik, faktor genetik, lingkungan, usia, dan jenis kelamin. Tujuan penelitian ini mengetahui karakteristik pasien NP berdasar atas gambaran histopatologi di Rumah Sakit Al-Islam Bandung. Penelitian ini menggunakan metode deskriptif cross-sectional menggunakan metode pengambilan sampel berupa total sampling. Data yang digunakan berupa data sekunder dari rekam medis periode 2012−2017 dan didapatkan data berjumlah 48 rekam medis. Pengolahan data dilakukan menggunakan program Microsoft Exel tahun 2011. Hasil penelitian menunjukkan frekuensi tertinggi NP terdapat pada usia 25−45 tahun sebanyak 23 kasus (48%), NP lebih sering terjadi pada perempuan dibanding dengan laki-laki, nevus intradermal dengan jumlah 38 kasus (79%), dan regio kepala dengan frekuensi 39 kasus (81%). Perkembangan NP pada usia dewasa dapat disebabkan oleh beberapa kemungkinan di antaranya paparan sinar matahari, sering melakukan aktivitas di luar lingkungan, dan kurang penggunaan sunblock. Efek paparan sinar matahari secara langsung dapat menyebabkan proses melanogensis melalui aktivasi tirosinase akibat teraktivasinya protein kinase C. Simpulan penelitian ini menunjukkan frekuensi tertinggi NP terdapat pada usia 25−45 tahun dengan perbandingan perempuan lebih banyak dibanding laki-laki, serta gambaran histopatologi yang terbanyak adalah nevus intradermal yang berlokasi di regio kepala. THE CHARACTERISTIC OF NEVUS PIGMENTOSUS BASED ON HISTOPATOLOGICAL FEATURES IN AL-ISLAM HOSPITAL BANDUNGNevus pigmentosus (NP) is the most common benign melanocytic lesion and peak at 25 to 26 years of age. The factors that influence NP is included aging, puberty, pregnancy, the used of systemic corticosteroid, genetic factors, environment, age, and gender. The purpose of this study was to describe the characteristics of NP patients based on histopathological features at Al-Islam Hospital Bandung. This study used a cross-sectional descriptive method using a total sampling method to collect the samples. The data used in this study is a secondary data from medical records 2012−2017 and obtained 48 medical records. Data processed by using the Microsoft Excel program 2011. The results showed that the highest frequency of NP occurred at the age of 25−45 years as many as 23 cases (48%), NP is more common in women rather than men, nevus  intradermal with 38 cases (79%), and the head region with a frequency of 39 cases (81%). The progression of NP in adult can be caused by several possibilities including sun exposure, frequent activities outside the environment and lack use of sunblock. The effects of direct sunlight exposure can cause the melanogenesis process through activation of tyrosinase due to activation of protein kinase C. The conclusions in this study showed that the highest frequency of NP is found at the age of 25−45 years old with a ratio of women is more than men, and the highest number of the histopathological features is intradermal nevus located in the head region.
Hubungan Usia dan Paritas dengan Kejadian Mioma Uteri di RSUD Al-Ihsan Provinsi Jawa Barat Tahun 2017 Neneng Sri Meilani; Ferry Achmad Firdaus Mansoer; Ismet Muchtar Nur; Dadi S. Argadiredja; Hidayat Widjajanegara
Jurnal Integrasi Kesehatan dan Sains Vol 2, No 1 (2020): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v2i1.4346

Abstract

Mioma uteri adalah tumor jinak otot polos rahim yang paling umum terjadi pada wanita. Kejadian mioma uteri di dunia ditemukan sebesar 20–35% dan di Indonesia mioma uteri ditemukan 2,39–11,7% pada semua pasien ginekologi yang dirawat di RSUD Al-Ihsan Bandung Jawa Barat periode Mei–Juni 2018. Penelitian bertujuan mengetahui hubungan usia dan paritas dengan kejadian mioma uteri. Penelitian ini menggunakan metode observasi analitik dengan pendekatan cross sectional. Sampel  dalam penelitian ini didapatkan 84 sampel yang terdiri atas 42 sampel yang didiagnosis mioma uteri dan 42 sampel yang tidak didiagnosis mioma uteri. Data didapatkan dari catatan rekam medik pasien yang dirawat periode tahun 2017 yang kemudian dianalisis secara uivariat dan bivariat. Dari hasil penelitian insidensi mioma uteri, paling banyak terjadi pada paritas nulipara, yaitu sebanyak 62% dan pada usia lebih dari 30 tahun 56%. Hasil uji statistik menggunakan chi square test didapatkan bahwa terdapat hubungan bermakna antara usia dan kejadian mioma uteri (p=0,0150) dan status paritas dengan kejadian mioma uteri (p = 0,035). Simpulan penelitian ini membuktikan bahwa terdapat hubungan usia dan paritas dengan kejadian mioma uteri. THE RELATIONSHIP 0F AGE AND PARITY WITH INCIDENCE OF UTERINE MYOMA IN RSUD AL-IHSAN PROVINCE WEST JAVA YEAR 2017 Uterine myoma is a benign smooth muscle tumor of the uterus which most often occurs in women. The incidence of uterine myoma in the world was found 20–35% and in Indonesia uterine myoma was found 2.39–11.7% in all gynecological patients treated. This study aims to determine the relationship between age and parity with the incidence of uterine myoma in RSUD Al-Ihsan Province West Java during May–June 2017. This research used analytical observation method with cross sectional approach design. The sample in this study obtained 84 samples consisting of 42 samples diagnosed with uterine myoma and 42 samples that were not diagnosed with uterine myoma. Data were obtained from patient’s medical records, then analyzed by uivariate and bivariate analysis. From the results of the study about uterine myoma incidence, that the most occur in nullipara parity as many as 62% and at the age of more than 30 years 56%. The results of statistical tests used chi square test showed that there was a significant relationship between age and the incidence of uterine myoma (p=0.015) and for parity status with the incidence of uterine myoma also had a significant relationship (p=0.0350). Conclusion, this study proves that there is a relationship between age and parity with the incidence of uterine myoma.
Karakteristik Pasien dengan Nodul Tiroid di Rumah Sakit Al-Ihsan Bandung Yuyun Saputri; Meta Maulida Damayanti; Ismet Muchtar Nur
Jurnal Integrasi Kesehatan dan Sains Vol 3, No 2 (2021): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v3i2.7412

Abstract

Nodul tiroid merupakan kasus yang dapat disebabkan oleh berbagai jenis gangguan kelenjar tiroid dan masih sering ditemukan. Sekitar 90% nodul tiroid bersifat jinak dan 10% bersifat ganas. Di Indonesia data statistik mengenai nodul tiroid masih sangat kurang. Penelitian ini bertujuan mengetahui karakteristik pasien dengan nodul tiroid. Penelitian ini menggunakan metode deskriptif observasional dengan pendekatan potong lintang yang dilaksanakan selama bulan September 2020. Teknik pengambilan sampel dalam penelitian ini adalah total sampling. Data didapatkan melalui rekam medis tahun 2018–2019 di Rumah Sakit Al-Ihsan Bandung dan didapatkan 72 rekam medis yang memenuhi kriteria inklusi. Hasil penelitian menunjukkan frekuensi tertinggi berdasar atas usia terdapat pada kelompok usia 40–49 tahun (32%). Frekuensi tertinggi berdasar atas jenis kelamin terdapat pada pasien perempuan (90%). Frekuensi tertinggi berdasar atas ukuran nodul tiroid terdapat pada kelompok >4 cm (72%). Frekuensi tertinggi berdasar atas gambaran histopatologi berupa adenomatoid goiter (74%). Simpulan penelitian ini menunjukkan frekuensi tertinggi nodul tiroid terdapat pada usia 40–49 tahun, perempuan, ukuran nodul tiroid >4 cm dan jenis adenomatoid goiter. Hal ini terjadi karena imunitas dan daya tahan tubuh seseorang menjadi menurun seiring dengan usia yang bertambah. Pada perempuan risiko penyakit nodul tiroid dapat meningkat dengan penggunaan hormon estrogen pada kontrasepsi oral, pada kehamilan, serta perubahan siklus menstruasi. CHARACTERISTICS OF  PATIENTS WITH THYROID NODULE AT THE AL-IHSAN HOSPITAL BANDUNGThyroid nodules are a disease caused by various types of thyroid gland disorders and are still often found. Approximately 90% of thyroid nodules are benign, and 10% are malignant. In Indonesia, statistical data for thyroid nodules are still limited. The purpose of this study was to determine the characteristics of patients with thyroid nodules. This study used a descriptive observational method with the cross-sectional approach was carried out during September 2020. The sampling technique in this research is total sampling. Data were obtained through medical records for January 2018–December 2019 at Al-Ihsan Hospital Bandung and obtained 72 medical records that met the inclusion criteria. The results showed that the highest frequency according to age was found in the 40–49 years group (32%). The highest frequency according to gender was found in female patients (90%). The highest frequency according to thyroid nodules size was in the >4 cm (72%). The highest frequency according to the histopathological features was found in adenomatoid goiter (74%). The conclusions in this study indicate that the highest frequency of thyroid nodules occurs at the age of 40–49 years, women, thyroid nodule size >4 cm, and adenomatoid goiter type. These happen because a person’s immunity and body resistance decrease with age. In women, the risk of thyroid nodule disease can increase cause using the hormone estrogen in oral contraceptives, in pregnancy, and changes in the menstrual cycle.
Hubungan Gangguan Neurobehavior dengan Paparan Pestisida pada Pekerja Perkebunan Teh PT X Kabupaten Cianjur Zahra Salsabila Firdaus; Ismet Muchtar Nur
Jurnal Riset Kedokteran Volume 1, No.1, Juli 2021, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (184.961 KB) | DOI: 10.29313/jrk.v1i1.315

Abstract

Abstract. Background: The use of pesticides in plantations or agriculture includes insecticides, herbicides, fungicides, rosenticides, and fumigants are chemicals from several groups, namely organochlorines, organophosphates, carbamates, and pyrethroids. Pesticides that are widely used in agriculture and plantations are the organophosphate group because this group is easier to decompose in nature. Besides being able to increase agricultural product yields, pesticides can also have a negative impact on workers in plantations due to exposure to pesticides, including nervous system disorders in the form of neurobehavioral disorders, which are harmful changes or functional disorders of the nerves, both the central nervous system and peripheral nervous system with symptoms / signs - a sign of changes in memory, attention, mood, disorientation, thinking irregularities, as well as changes in somatic, sensory, and cognitive function as neurotoxic effects due to the use of neurotoxicants. Aim: Research on workers in tea plantations aims to determine the relationship between neurobehavioral disorders in spraying workers (who use pesticides) in tea plantations. Method: This study used an observational analytic method which aims to reveal the correlative relationship between variables using a cross sectional group design approach and using a total sampling technique. The population and research sample amounted to 30. This study used a questionnaire The German Q18 Quesionnaire. The independent variable in this study is pesticides and the dependent variable in this study is neurobehavioral disorders. Univariate data analysis using frequency distribution and bivariate using chi-square. Result : The results showed that there was a relationship between the neurubehavioral disorders experienced by workers and the length of exposure to pesticides seen from their working period. The number of respondents who experienced neurobehavior disorders was 18 people (60.0%) had negative neurobehavioral disorders and as many as 12 people (40.0%) had positive neurobehavioral disorders. Chi-Square test results obtained p value = 0.011 <α (0.05), which means that there is a significant relationship / correlation between neurobehavioral disorders and exposure to pesticides in tea plantation workers of PT. X Cianjur Regency. Conclusion: in this study, there are neurobehavior disorders in plantation wprkers who use pesticides. Abstrak. Latar Belakang: Penggunaan pestisida dalam perkebunan atau pertanian meliputi insektisida, herbisida, fungisida, rosentisida, dan fumigan merupakan bahan kimia dari beberapa golongan yaitu organoklorin, organofosfat, karbamat, dan piretroid. Pestisida yang banyak digunakan di bidang pertanian dan perkebunan adalah golongan organofosfat karena golongan ini lebih mudah terurai di alam. Selain dapat meningkatkan hasil produk pertanian, pestisida juga dapat memberikan dampak negatif bagi pekerja di perkebunan akibat paparan pestisida, antara lain gangguan sistem saraf berupa gangguan neurobehavioral, yaitu perubahan berbahaya atau gangguan fungsional saraf, baik sistem saraf pusat dan sistem saraf tepi dengan gejala/tanda – tanda perubahan daya ingat, perhatian, mood, disorientasi, ketidakteraturan berpikir, serta perubahan fungsi somatik, sensorik, dan kognitif sebagai efek neurotoksik akibat penggunaan neurotoksikan. Tujuan: Penelitian pada pekerja di perkebunan teh bertujuan untuk mengetahui hubungan gangguan neurobehavioral pada pekerja penyemprotan (pengguna pestisida) di perkebunan teh. Metode: Penelitian ini menggunakan metode observasional analitik yang bertujuan untuk mengungkap hubungan korelasional antar variabel dengan menggunakan pendekatan cross sectional group design dan menggunakan teknik total sampling. Populasi dan sampel penelitian berjumlah 30. Penelitian ini menggunakan kuesioner The German Q18 Quesionnaire. Variabel bebas dalam penelitian ini adalah pestisida dan variabel terikat dalam penelitian ini adalah gangguan neurobehavioral. Analisis data univariat menggunakan distribusi frekuensi dan bivariat menggunakan chi-square. Hasil : Hasil penelitian menunjukkan bahwa ada hubungan antara gangguan neurobehavioral yang dialami pekerja dengan lama paparan pestisida dilihat dari masa kerjanya. Jumlah responden yang mengalami gangguan neurobehavior sebanyak 18 orang (60,0%) mengalami gangguan neurobehavior negatif dan sebanyak 12 orang (40,0%) mengalami gangguan neurobehavior positif. Hasil uji Chi-Square diperoleh p value = 0,011 < (0,05), yang berarti terdapat hubungan/korelasi yang signifikan antara gangguan neurobehavioral dengan paparan pestisida pada pekerja perkebunan teh PT. X Kabupaten Cianjur. Kesimpulan: pada penelitian ini terdapat gangguan neurobehavior pada pekerja perkebunan yang menggunakan pestisida.
Association between Chronic Inflammation of Basal Plate and Decidua Existences with Placenta Accreta Spectrum Yuktiana Kharisma; Meike Rachmawati; Abdul Hadi Hassan; Ismet Muchtar Nur; Hasrayati Agustina; Sri Suryanti
Global Medical & Health Communication (GMHC) Vol 10, No 2 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (412.693 KB) | DOI: 10.29313/gmhc.v10i2.9060

Abstract

The placenta accreta spectrum (PAS) is an abnormal placenta condition with a high level of morbidity and mortality in both the mother and fetus. The PAS has a multifactorial etiology, one of which is a chronic inflammation of the basal plate (CIBP) and the decidual existences (DE). The study aims to analyze the association between CIBP and DE with PAS. It was an analytical observational with a cross-sectional study design on 50 placentae (25 PAS paraffin block, 25 standard placenta samples) from Dr. Hasan Sadikin General Hospital and other health centers that meet the inclusion and exclusion criteria. The data are taken from PAS patients from January 2015–December 2020. All samples will be stained with hematoxylin-eosin (HE), then undergo histopathological examination. The result of the studies analyzed statistically using Fisher's exact. CIBP in PAS was found in 21/25 cases, while in the normal placenta was found in 16/21 patients. The DE is positive in 15/25 cases of PAS, whereas the normal placenta was found in all cases. The association between CIBP and PAS is insignificant statistically (p=0.19), while the DE showed a significant relationship with PAS (p=0.00). The presence of the decidua is related to the regulation of trophoblastic invasion into the myometrium in PAS cases. CIBP can occur due to the reaction of decidua tissue to trophoblastic invasion or an infectious agent. The pathogenesis of PAS needs further understanding so that the appropriate therapy can be found for its prevention and management.
Co-Authors Abdul Hadi Hassan Abdul Hadi Hassan Agung Firmansyah Sumantri Ahmad Heru Sopyan Andriane, Yuke Annisa Rahmah Furqaani Asty Sabrina Utami Aurora Rahma Koesdinar Ayu Prasetia Ayu Prasetia Dadi S. Argadiredja Deis Hikmawati Ennok Nisa Islamiati Ermina Widiyastuti Fatimah Lidya Andriani Fatimah Lidya Andriani, Fatimah Lidya Ferry Achmad Firdaus Mansoer Hasrayati Agustina Hendro Sudjono Yuwono Herri S. Sastramihardja Hidayat Widjajanegara Indri Budiarti Indri Budiarti Julia Hartati Lelly Yuniarti Lina Munita Sari Sari Maya Tejasari Meike Rachmawati Meta Maulida Damayanti Mia Kusmiati Muhammad Gibran Al Madani Muthiana Rizky Muthiana Rizky, Muthiana Naufal Fadhillah Alam Neneng Sri Meilani Neng Aneu Nurul Hidayah Noormartany Nurul Izzati Fauzia Pradipto Atyanto Wibowo Raden Anita Indriyanti Radina, Faqih Sally Mahdiani Santun Bhekti Rahimah Sari, Ajeng Kartika Siddiq, Tita Barriah Siska Nia Irasanti Siti Annisa Devi Trusda, Siti Annisa Devi Sri Suryanti Taufik Muhammad Fakih Tita Barriah Siddiq Wida Purbaningsih Yani Triyani Yenolinsky, Yolanda Yolanda Yenolinsky Yuktiana Kharisma Yuktiana Kharisma Yuyun Saputri Zahra Salsabila Firdaus Zulmansyah Zulmansyah