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All Journal Riset Ilmu Manajemen Bisnis dan Akuntansi Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan Jurnal Medika Nusantara Jurnal Cakrawala Pendidikan dan Biologi (jucapenbi)
Salsabila Rahman
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Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Nursing Public Health Other

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Eksplorasi Endofit Sambung Nyawa: Potensi Mikroba dalam Penemuan Obat dan Bioaktivitasnya Salsabila Rahman
Jurnal Medika Nusantara Vol. 3 No. 1 (2025): Jurnal Medika Nusantara
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v3i1.1669

Abstract

Gynura procumbens, also known as “Sambung Nyawa,” is a medicinal plant known for its various therapeutic properties. This study aims to explore the potential of endophytic microbes living inside Gynura procumbens plants as a source of bioactive compounds with pharmaceutical applications. Endophytic microbes are microorganisms that live symbiotically in plant tissues without causing damage, and are known to produce secondary metabolites similar to their host plants. In this study, endophytic microbes in the form of bacteria and fungi were isolated from various plant parts, including leaves, stems, and roots. A total of 12 isolates were obtained, consisting of 7 bacteria and 5 fungi, which were identified using molecular techniques. The isolates were tested for antimicrobial, antioxidant and cytotoxic activities. The antimicrobial assay showed significant inhibitory effects against Staphylococcus aureus and Candida albicans, where isolates from the genus Streptomyces and Penicillium had the highest activity. Antioxidant activity was measured using the DPPH method, and two bacterial isolates showed strong free radical scavenging ability. Cytotoxic assays on MCF-7 breast cancer cells revealed that the fungal isolates, mainly from the genus Penicillium and Aspergillus, had strong anticancer activity. The results of this study indicate that endophytic microbes from Gynura procumbens contain bioactive compounds that have potential as antimicrobial, antioxidant, and anticancer agents. This study confirms the importance of exploring endophytic microbes from medicinal plants in the discovery of new drugs and the development of therapeutic agents. Further research is needed to isolate and characterize the specific compounds responsible for these bioactivities as well as evaluate their potential in clinical applications.
Identifikasi dan Karakterisasi Bakteri Asam Laktat dari Bekasam Ikan Gabus (Channa striata) Berdasarkan Pewarnaan Gram dan Morfologi Koloni Salsabila Rahman; Ardi Mustakim
Jurnal Cakrawala Pendidikan dan Biologi Vol. 2 No. 3 (2025): September: Jurnal Cakrawala Pendidikan dan Biologi
Publisher : Asosiasi Riset Ilmu Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/jucapenbi.v2i3.580

Abstract

Bekasam is a traditional Indonesian fermented food produced through spontaneous fermentation involving microorganisms, particularly lactic acid bacteria (LAB). LAB plays a crucial role in the fermentation process by producing lactic acid, which lowers pH, inhibits pathogenic microbial growth, and enhances flavor and food safety. This study aimed to identify and characterize LAB isolated from fermented snakehead fish (Channa striata) based on Gram staining and colony morphology. The research began with bacterial isolation using NA Nutrient Agar, followed by macroscopic observation of colony characteristics including shape, edge, elevation, color, and size. Subsequently, Gram staining was performed to determine the cell wall structure and microscopic morphology of the bacteria. The results showed that the bacterial isolates from bekasam generally had circular colonies, white to cream in color, smooth surface, and were Gram-positive rod-shaped cells. In conclusion, bekasam from snakehead fish contains dominant lactic acid bacteria with distinctive colony morphology and Gram-positive characteristics, indicating potential as a natural starter culture for food fermentation.
Pandangan Pelaku Ekonomi tentang Pentingnya Peranan Uang dalam Proses Interaksi dan Transaksi Harian Hafif Setiawan; Salsabila Rahman; Melani Rusli; Muhammad Arfan Harahap
Jurnal Rimba Riset Ilmu manajemen Bisnis dan Akuntansi Vol. 3 No. 4 (2025): November : Riset Ilmu Manajemen Bisnis dan Akuntansi
Publisher : Asosiasi Riset Ilmu Manajemen Kewirausahaan dan Bisnis Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/rimba.v3i4.2370

Abstract

This study aims to describe the perspectives of economic actors regarding the importance of money in daily interactions and transactions. Money, as a medium of exchange, not only facilitates the transfer of goods and services but also shapes more efficient and structured economic behavior. In everyday activities, economic actors view money as an instrument that provides value certainty, transactional convenience, and flexibility in managing needs and expenditures. The role of money is also understood as a factor influencing socio-economic relationships, as interactions between individuals are often grounded in transactional processes that require trust and universally accepted exchange values. Furthermore, the development of payment technologies has broadened economic actors’ understanding of money, especially within the context of digitalized transactions. This study illustrates that money is not merely a transactional tool but also a crucial element in shaping the socio-economic dynamics of modern society. The findings are expected to contribute to microeconomic discussions related to how economic actors utilize money as a fundamental instrument in daily economic activities.
Potensi Biokimia Aloe vera (L.) Burm.f. sebagai Agen Penyembuhan Luka dan Basis Formulasi Sediaan Topikal Farmasi Salsabila Rahman; Ardi Mustakim
Jurnal Ventilator Vol. 3 No. 4 (2025): Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v3i4.2137

Abstract

Aloe vera (L.) Burm.f. is a bioactive plant containing polysaccharides, anthraquinones, sterols, vitamins, minerals, and glycoproteins, contributing to wound healing through anti-inflammatory, antibacterial, antioxidant mechanisms, fibroblast stimulation, and accelerated re-epithelialization. This study employed a systematic literature review (SLR) of 37 peer-reviewed articles (2018–2025) to evaluate the biochemical potential of Aloe vera and its application as a basis for modern pharmaceutical topical formulations. Results revealed that acemannan increased fibroblast proliferation by up to 200, modulated TGF-1, enhanced type I and III collagen deposition, and accelerated re-epithelialization. Anthraquinones such as aloin and emodin exhibited antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Nanoemulsion and nanogel formulations improved transdermal penetration up to threefold compared to conventional gels. These findings highlight Aloe vera’s potential as a wound healing agent and a basis for modern pharmaceutical topical preparations.
Co-Authors Ardi Mustakim Hafif Setiawan Melani Rusli MUHAMMAD ARFAN HARAHAP