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Mulyadewi, Amelia Luthfiyah
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Journal : Amerta Nutrition

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Efek Pemberian Kefir Susu Kambing Madu pada Gambaran Histopatologi Pankreas dan Fungsi Ginjal pada Tikus Diabetes: Effects of Honey Goat Milk Kefir on Pancreatic Histopathology and Renal Function in Diabetic Rats Mulyadewi, Amelia Luthfiyah; Ilmi, Ibnu Malkan Bakhrul; Hardiansyah, Angga
Amerta Nutrition Vol. 8 No. 3SP (2024): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 4th Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v8i3SP.2024.412-421

Abstract

Background: The prevalence of diabetes is rising. Chronic metabolic disease type 2 diabetes may damage renal function and harm the pancreas. One of the initiatives to prevent and manage type 2 diabetes through functional foods. The antidiabetic and antioxidant properties of goat milk kefir with honey are thought to help heal kidney and pancreatic damage. Objectives: Evaluating the effects of feading fermented goat milk with honey on pancreatic histopathology and renal function in diabetic rats. Methods: A true experimental study conducted on 42 male Sprague-Dawley rats aged 6-8 weeks were divided into Six groups: Healthy Rats (KS); DM Rats (KN); quercetin (K1); metformin (K2); Kefir (P1); Preventive (P2). Diabetic rats type 2 were conditioned by HFD and injecting streptozotocin. Oral kefir was given 1.8 ml/200g BW/day for 21 days to groups KK and KP. Renal function was analyzed with pre-post tests through measurement of serum levels urea and creatinine, while the histopathological features were evaluated at the end of the study. The Kruskal-Wallis and post hoc Mann-Whitney test are used to analyze the data. Results: P1 rats had Creatinine level of 0.57 ± 0.07 mg/dL; BUN 27.56 ± 6.22 mg/dL; Beta Cell Count 104.2; Island Area of Langerhans 170.26. The levels of BUN (p-value=0.083), creatinine (p-value=0.016), and Langerhans island area (p-value=0.026). Creatinine of rat P1 were significantly different from KN (p-value<0.05). Conclusions: Goat milk kefir with honey in type 2 diabetic rats show beneficial effects on serum BUN, creatinine, and histopathological features of the pancreas as treated with metformin.
Potensi Kefir Susu Kambing dengan Penambahan Madu Randu dalam Mencegah Stress Oksidatif pada Tikus Diabetes : Potential of Randu Honey Kefir to Prevent Oxidative Stress in Diabetic Rats Ilmi, Ibnu Malkan Bakhrul; Marjan, Avliya Quratul; Harfiani, Erna; Kusuma, Indra; Wahyuningsih, Utami; Fikriana, Chika Nur; Mulyadewi, Amelia Luthfiyah
Amerta Nutrition Vol. 9 No. 1SP (2025): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 5th Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i1SP.2025.31-40

Abstract

Background: More than 90% of adults with type 2 diabetes are overweight or obese. This condition is known to increase oxidative stress, which contributes to cellular damage and disease complications. As a functional food, kefir has long been recognized for its various health benefits, including anti-inflammatory, antioxidant, and antidiabetic properties. Objectives: This study aimed to analyze the potential of randu honey kefir in preventing oxidative stress in diabetic rats. Methods: This study employed a randomized block design with a 21-day intervention period. A total of 42 male Sprague Dawley rats aged 6–8 weeks were divided into six groups: KS (standard), KN (negative control), K1 (quercetin), K2 (metformin), P1 (randu honey kefir 1.8 mL/200g BW), and P2 (preventive group). Diabetes was induced using streptozotocin at 40 mg/kgBW combined with a high-fat diet. Malondialdehyde (MDA) levels were analyzed using spectrophotometry, while interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) levels were measured using ELISA kits. Results: Significant differences (p-value<0.05) were observed in MDA, TNF-α, and IL-6 levels between the P1 and P2 groups compared with the KN group. Randu honey kefir groups showed mean oxidative stress marker levels comparable to those of quercetin and metformin treatments, including MDA (P1: 32.9 ± 29.35 nmol/mL; P2: 23.77 ± 11.63 nmol/mL), TNF-α (P1: 45.37 ± 31.25 pg/mL; P2: 37.81 ± 27.00 pg/mL), and IL-6 (P1: 64.81 ± 21.35 pg/mL; P2: 59.23 ± 14.95 pg/mL). Conclusions: Randu honey kefir intervention demonstrates potential in suppressing oxidative stress in diabetic rats.
Co-Authors Avliya Quratul Marjan Erna Harfiani Fikriana, Chika Nur Hardiansyah, Angga Ilmi, Ibnu Malkan Bakhrul Indra Kusuma Utami Wahyuningsih