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All Journal Nusantara Science and Technology Proceedings Jurnal Hukum Mimbar Justitia
Andryani, Yani
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences

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Hematopoietic Stem Cell Transplant as Symptomatic Treatment for Myasthenia Gravis: A Literature Review Sutrisno, Jessica Amadea; Andryani, Yani; Devinda, Ni Luh Airin Gita
Nusantara Science and Technology Proceedings Multi-Conference Proceeding Series F
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/nstp.2024.4606

Abstract

Myasthenia gravis (MG) is an autoimmune neurological disorder that impairs communication at the neuromuscular junction. Over the past seven decades, its global incidence has steadily increased. Approximately 10–20% of MG patients do not respond adequately to or cannot tolerate conventional treatments. Hematopoietic stem cells (HSCs), which are multipotent cells capable of producing all blood cell types and restoring the hematopoietic system, are being explored as a therapeutic option. Hematopoietic stem cell transplantation (HSCT) is under investigation as a potential treatment for severe and refractory MG, with ongoing research aimed at enhancing its safety, and efficacy, and identifying optimal candidates for the therapy. This paper aimed to evaluate the efficacy of hematopoietic stem cell transplantation (HSCT) as a therapeutic option for managing symptomatic myasthenia gravis (MG), especially in cases unresponsive to conventional therapies. A systematic search identified five studies, comprising two cohort studies and three case reports. Most patients in these studies demonstrated promising improvement following HSCT treatment, as indicated by a reduction in MGFA scores and improved clinical manifestations during follow-up assessments. This treatment approach has demonstrated significant potential. However, the current studies are susceptive to bias, and more preclinical research along with high-quality clinical trials, large-scale are required to determine if this emerging treatment can meet the anticipated outcomes.
Pergeseran Asas Legalitas Formal ke Material dalam KUHP Baru dan Konsekuensinya terhadap Hukum Adat Hidayat, Sarip; Andryani, Yani; Rifa’I, Iman Jalaludin; Muliani, Raden Yeni
Jurnal Hukum Mimbar Justitia Vol 11, No 1 (2025): Vol 11, No 1 (2025): Published 30 Juni 2025
Publisher : Universitas Suryakancana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35194/jhmj.v11i1.5160

Abstract

Pergeseran asas legalitas dari yang semula bersifat formal dalam KUHP lama ke arah asas legalitas material dalam KUHP baru, serta implikasi dari perubahan ini terhadap eksistensi dan penerapan hukum adat di Indonesia. Asas legalitas formal menekankan bahwa tidak ada perbuatan yang dapat dipidana tanpa ketentuan undang-undang yang tertulis terlebih dahulu, sedangkan asas legalitas material membuka ruang bagi penilaian keadilan substantif dan pengakuan terhadap sumber hukum tidak tertulis, termasuk hukum adat. Metode pendekatan Yuridis-Empiris dan deskriftif kualitatif, penelitian ini menunjukkan bahwa KUHP baru secara eksplisit mengakui hukum adat sebagai salah satu sumber hukum pidana, asalkan memenuhi syarat-syarat tertentu. Konsekuensinya, hukum adat memiliki posisi yang lebih kuat dalam sistem hukum nasional, namun juga menimbulkan tantangan serius terkait kepastian hukum, keseragaman penegakan hukum, dan potensi pelanggaran hak asasi manusia. Penelitian ini merekomendasikan adanya pengaturan lebih lanjut dan pembentukan pedoman nasional agar penerapan hukum adat tidak bertentangan dengan prinsip-prinsip universal hukum pidana modern.
Co-Authors Devinda, Ni Luh Airin Gita Muliani, Raden Yeni Rifa’i, Iman Jalaludin Sarip Hidayat, Sarip Sutrisno, Jessica Amadea