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All Journal JURNAL PENDIDIKAN TAMBUSAI Buletin Kedokteran dan Kesehatan Prima
Komala, William
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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In vitro cholesterol-lowering activity of probiotics isolated from commercial products in Medan City Komala, William; Fachrial, Edy; Lister, Clarissa
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.6378

Abstract

Regular consumption of probiotic drinks has been shown to provide numerous benefits for human health. One of the primary benefits is boosting the immune system by promoting optimal digestive health. Ten brands of probiotic milk were collected, and bacterial isolates were obtained through a series of isolation and purification steps. The characterization of these isolates involved morphological and biochemical tests, including Gram staining, catalase activity assessment, and tolerance testing under simulated gastric conditions. The cholesterol-lowering activity of the isolates was evaluated in vitro by assessing their ability to reduce cholesterol levels in a simulated intestinal environment. The results demonstrated the presence of potential probiotic strains with cholesterol-lowering activity, providing a foundation for further research into the development of functional dairy products with cholesterol-lowering properties. The results indicated that probiotic milk from commercial beverages demonstrated a favorable response to bile salts in individuals with high cholesterol levels. Probiotic bacteria, such as Lactobacillus acidophilus, can survive in bile, facilitating the deconjugation of bile salts. This suggests that regular consumption of probiotic milk may aid in managing cholesterol levels in individuals with unhealthy lipid profiles. A significant relationship exists between the tolerance of probiotic milk to the digestive environment and its effectiveness in managing cholesterol. Mechanisms including bile salt deconjugation, short-chain fatty acid (SCFA) production, and increased cholesterol excretion contribute to cholesterol management. With appropriate formulation, probiotic milk can effectively control cholesterol levels, particularly in individuals at risk for cardiovascular disease.
Penyakit Degeneratif: Tantangan dan Peluang dalam Penelitian dan Pengobatan Komala, William; Nasution, Alyssa Naura
Jurnal Pendidikan Tambusai Vol. 9 No. 1 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jptam.v9i1.25735

Abstract

Penyakit degeneratif merupakan kelompok penyakit yang ditandai dengan kemunduran fungsi seluler, jaringan, atau organ akibat proses biologis yang terjadi seiring waktu. Penelitian ini membahas tantangan dan peluang dalam penelitian serta pengobatan penyakit degeneratif, termasuk penyakit neurodegeneratif, kardiovaskular, metabolik, dan muskuloskeletal. Studi ini menggunakan metode kajian pustaka dengan analisis isi dari berbagai sumber primer dan sekunder. Hasil penelitian menunjukkan bahwa faktor risiko utama penyakit degeneratif adalah penuaan, genetika, dan gaya hidup yang tidak sehat. Kompleksitas mekanisme biologis, resistensi terhadap terapi, dan tingginya biaya penelitian menjadi hambatan utama dalam pengobatan penyakit ini. Namun, peluang besar terbuka melalui perkembangan teknologi seperti terapi gen, terapi sel punca, dan obat-obatan inovatif. Selain itu, pencegahan primer melalui pola hidup sehat, imunisasi, dan edukasi kesehatan dapat menekan angka kejadian penyakit degeneratif. Kolaborasi multidisiplin antara ilmuwan, praktisi medis, dan masyarakat menjadi kunci dalam menghadapi tantangan ini serta meningkatkan kualitas hidup penderita penyakit degeneratif.
In vitro cholesterol-lowering activity of probiotics isolated from commercial products in Medan City Komala, William; Fachrial, Edy; Lister, Clarissa
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.6378

Abstract

Regular consumption of probiotic drinks has been shown to provide numerous benefits for human health. One of the primary benefits is boosting the immune system by promoting optimal digestive health. Ten brands of probiotic milk were collected, and bacterial isolates were obtained through a series of isolation and purification steps. The characterization of these isolates involved morphological and biochemical tests, including Gram staining, catalase activity assessment, and tolerance testing under simulated gastric conditions. The cholesterol-lowering activity of the isolates was evaluated in vitro by assessing their ability to reduce cholesterol levels in a simulated intestinal environment. The results demonstrated the presence of potential probiotic strains with cholesterol-lowering activity, providing a foundation for further research into the development of functional dairy products with cholesterol-lowering properties. The results indicated that probiotic milk from commercial beverages demonstrated a favorable response to bile salts in individuals with high cholesterol levels. Probiotic bacteria, such as Lactobacillus acidophilus, can survive in bile, facilitating the deconjugation of bile salts. This suggests that regular consumption of probiotic milk may aid in managing cholesterol levels in individuals with unhealthy lipid profiles. A significant relationship exists between the tolerance of probiotic milk to the digestive environment and its effectiveness in managing cholesterol. Mechanisms including bile salt deconjugation, short-chain fatty acid (SCFA) production, and increased cholesterol excretion contribute to cholesterol management. With appropriate formulation, probiotic milk can effectively control cholesterol levels, particularly in individuals at risk for cardiovascular disease.
Co-Authors Edy Fachrial Lister, Clarissa Nasution, Alyssa Naura