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Inhibitory ability of robusta coffee bean extract against Staphylococcus epidermidis Lister, Clarissa; Ginting, Rapael; Panggabean, Endah Ansylla; Tarigan, Ermilia Laurensya
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5710

Background: Treatment of infections generally uses chemical antibiotics, but chemical antibiotics have effects such as increasing toxicity to the body. The solution to overcome this problem is to use antibiotics from natural ingredients, such as coffee. Objective: This study aims to determine the effectiveness of robusta coffee bean extract (Coffea canephora) in inhibit the growth of Staphylococcus epidermidis bacteria. Methods: This research is an experimental study with a post test only control group design. There were 10 groups in this study, namely 2 control groups and 8 treatment groups. The technique used is disc diffusion to see the role of robusta coffee bean ethanol extract in inhibiting the growth of Staphylococcus epidermidis bacteria. The data was analyzed using the Mann-Whitney test to determine the difference between treatments. Results: The results of the Mann-Whitney test showed that there were differences in the average inhibition zone of Robusta coffee bean extract and the inhibitory power at each concentration (p<0.05). The concentration that has the highest inhibition is the concentration of 500 mg/ml. Conclusion: It can be said that there is an effectiveness of robusta coffee bean extract in reducing Staphylococcus epidermidis bacteria because the specified concentration inhibition zone is obtained.

The effect of telang flower extract on kidney function and histopathological features of obese rat kidneys Astuti, Mia Puji; Lister, Clarissa; Renaldi, Muhammad Rizal; Suhartina, Suhartina
Jurnal Prima Medika Sains Vol. 6 No. 1 (2024): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i1.5453

This study aims to determine the effect of oral administration of telang flower extract in several doses on histopathological changes in kidney organs. This study used a post test only control group design. Researchers used 6 Wistar rats for each experimental group, so that the total number of test animals in this study was 24. Grouping of test animals was done randomly into 4 test groups. Histopathological observations of kidney tissue were made by comparing the control and treatment groups. Changes observed will be the presence of fatty degeneration (vacuolization), necrosis and hydrophic degeneration. To obtain quantitative data, scoring was performed on each change found. The data from the study were then analyzed with the help of SPSS. Data normality test was analyzed by Kolmogorov-Smirnov test (p > 0.05). To test the significance between test groups, one-way analysis of variance or One Way ANOVA technique was conducted at 95% confidence level (p < 0.05). Further analysis or test was conducted using Post Hoc Test with LSD technique. The results showed that the administration of telang flower extract at a dose of 600mg/KgBB was effective in improving kidney function in obese Wistar white rats. This improvement is seen through increased levels of ureum, creatinine, and improved renal histological structure. Histopathological observation of kidney tissue showed that treatment group 3, which received telang flower extract at a dose of 600mg/KgBB, experienced significant improvement and was closer to the control group than the other groups.

Participation of pregnant women in pregnancy exercise: The role of knowledge, attitudes, and husband's support Sembiring, Imelda; Liena, Liena; Suyono, Tan; Lister, Clarissa; Suwarno, Suwarno; Sulistijanto, Eddy
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.6237

Pregnancy exercise offers numerous benefits for both mother and child. However, many pregnant women do not participate in this activity. This study aims to identify factors influencing pregnant women's participation in pregnancy exercise at Darussalam Health Center, Medan City. A cross-sectional study was conducted on 60 pregnant women visiting the Darussalam Health Center. Data were collected using a structured questionnaire and analyzed using Chi-square tests and logistic regression. The findings indicate that most pregnant women did not participate in pregnancy exercise. Knowledge of the benefits of prenatal exercise, positive attitudes toward exercise, and partner support were significant predictors of participation. Multivariate analysis confirmed that these three factors were independently associated with exercise participation. This study highlights the importance of knowledge, attitudes, and partner support in promoting prenatal exercise among pregnant women. Health education programs focusing on these factors could encourage more women to engage in regular physical activity during pregnancy.

In vitro cholesterol-lowering activity of probiotics isolated from commercial products in Medan City Komala, William; Fachrial, Edy; Lister, Clarissa
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.6378

Regular consumption of probiotic drinks has been shown to provide numerous benefits for human health. One of the primary benefits is boosting the immune system by promoting optimal digestive health. Ten brands of probiotic milk were collected, and bacterial isolates were obtained through a series of isolation and purification steps. The characterization of these isolates involved morphological and biochemical tests, including Gram staining, catalase activity assessment, and tolerance testing under simulated gastric conditions. The cholesterol-lowering activity of the isolates was evaluated in vitro by assessing their ability to reduce cholesterol levels in a simulated intestinal environment. The results demonstrated the presence of potential probiotic strains with cholesterol-lowering activity, providing a foundation for further research into the development of functional dairy products with cholesterol-lowering properties. The results indicated that probiotic milk from commercial beverages demonstrated a favorable response to bile salts in individuals with high cholesterol levels. Probiotic bacteria, such as Lactobacillus acidophilus, can survive in bile, facilitating the deconjugation of bile salts. This suggests that regular consumption of probiotic milk may aid in managing cholesterol levels in individuals with unhealthy lipid profiles. A significant relationship exists between the tolerance of probiotic milk to the digestive environment and its effectiveness in managing cholesterol. Mechanisms including bile salt deconjugation, short-chain fatty acid (SCFA) production, and increased cholesterol excretion contribute to cholesterol management. With appropriate formulation, probiotic milk can effectively control cholesterol levels, particularly in individuals at risk for cardiovascular disease.

The Relationship of Motivation for Entering the Faculty ff Medicine and Dentistry on Student's Academic Achievement Mei Enjelika br Lubis, Rima; Lister, Clarissa; Hendriani Djuang, Michelle
Jurnal Multidisiplin Indonesia Vol. 3 No. 1 (2024): Jurnal Multidisiplin Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jmi.v3i1.1025

Education is essential in modern society, both politically and economically. Medical training plays a critical role in producing qualified doctors. Competent doctors, the result of training provided by quality medical education institutions, provide quality health services to the community. Motivation is significant in determining learning success. This research aims to determine the relationship between motivation for entering medical and dental faculties and student's academic achievement. An online survey was used to collect data for this research. The sample population of the research was medical and dental students from Prima Indonesia University. The strength of the Motivation for Medical Students (SMMS) instrument, translated into Indonesian, was used to collect data for student motivation. 123 out of 493 medical and dental students participated in this research. Survey results show that suitability and interest are why students enter medical and dental faculties. The Spearman's rho correlation test shows no significant relationship between motivation variables and GPA, with Sig. (2-tailed) of 0.303 where p > 0.05. The Mann-Whitney test shows no statistically significant difference between the two genders with Sig. (2-tailed) of 0.558 where p > 0.05. This study shows that although there are various reasons and motivations for entering medical and dental faculties, there is no relationship between the above and academic achievement.

Gambaran Hasil Pemeriksaan Histopatologi Penderita Tuberkulosis Jaringan Lunak di Laboratorium Patologi Anatomi Rumah Sakit Umum Madani Medan Periode 2020-2024 Hutapea, Risma Ronauli; Lina, Juliana; Lister, Clarissa
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i9.61736

Soft tissue tuberculosis is a rare form of extrapulmonary tuberculosis characterized by Mycobacterium tuberculosis infection of the subcutaneous tissue. This condition is important to recognize because its symptoms are nonspecific and often mimic malignancy, often referred to as a "good imitator." According to WHO data from 2023, the global TB incidence rate was 134 per 100,000 population, with Indonesia ranking second highest in the world. This study aims to describe the results of histopathological examinations of soft tissue tuberculosis patients at Madani General Hospital, Medan, during the period 2020–2024. The method used was a retrospective descriptive study through a review of the medical records of patients examined in the Anatomical Pathology Laboratory. Analysis was conducted on variables such as age, gender, lesion location, and histopathological results. The results showed that the largest age group was 19–27 years (25%), while the smallest was 10–18 years (7.5%). The gender distribution was balanced between males and females (50% each). The most common lesions were the neck and back (22.5%), while rarer locations, such as the axilla, buttocks, mandible, groin, and elbow, occurred in only 2.5% each. All cases were confirmed by histopathology, underscoring the importance of this examination to rule out malignancy and expedite the appropriate management of extrapulmonary tuberculosis.

Family Role on the Pregnant Women’s Knowledge Toward Obstetric Danger Signs Handayani, Rr. Novita Wahyu; Nasution, Ali Napiah; Lister, Clarissa
Journal of Maternal and Child Health Vol. 10 No. 4 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/thejmch.2025.10.04.05

Background: Obstetric danger signs are an important indicator that pregnant women need to recognize to prevent complications and reduce maternal mortality. This study aims to analyze the determinants of knowledge about obstetric danger signs in pregnant women, with a special focus on the role of family function as measured by the family APGAR instrument. Subjects and Method: A cross-sectional study was conducted on 48 pregnant women who visited the Padang Bulan Community Health Center, Medan, during August-September 2024. The dependent variable is the level of knowledge about obstetric danger signs. Independent variables were age, education level, employment status, number of pregnancies (parity), income, and family function (APGAR score). Data collection was conducted using questionnaires on obstetric danger signs and family APGAR instruments. Data analysis included univariate, bivariate (Chi-Square), and multivariate (logistic regression) analysis. Results: The majority of subjects (72.9%) had good knowledge of obstetric danger signs. Bivariate analysis showed that education level (p=0.008) and family function (p=0.005) had a significant relationship with knowledge level, while age, employment status, parity, and income showed no significant relationship. Multivariate analysis confirmed that highly functional family function (OR= 10.47; 95% CI= 1.56 to 70.40; p =0.016) and higher education levels (OR= 6.83; 95% CI= 1.31 to 35.61; p = 0.023) were significant independent predictors for good knowledge of obstetric danger signs. Conclusion: Family function and education level are the main determinants of pregnant women's knowledge about obstetric danger signs. Maternal health education programs need to consider family involvement and pay special attention to pregnant women with low levels of education to improve understanding of obstetric danger signs, which can ultimately contribute to a decrease in maternal morbidity and mortality rates.

Inhibitory ability of robusta coffee bean extract against Staphylococcus epidermidis Lister, Clarissa; Ginting, Rapael; Panggabean, Endah Ansylla; Tarigan, Ermilia Laurensya
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5710

Background: Treatment of infections generally uses chemical antibiotics, but chemical antibiotics have effects such as increasing toxicity to the body. The solution to overcome this problem is to use antibiotics from natural ingredients, such as coffee. Objective: This study aims to determine the effectiveness of robusta coffee bean extract (Coffea canephora) in inhibit the growth of Staphylococcus epidermidis bacteria. Methods: This research is an experimental study with a post test only control group design. There were 10 groups in this study, namely 2 control groups and 8 treatment groups. The technique used is disc diffusion to see the role of robusta coffee bean ethanol extract in inhibiting the growth of Staphylococcus epidermidis bacteria. The data was analyzed using the Mann-Whitney test to determine the difference between treatments. Results: The results of the Mann-Whitney test showed that there were differences in the average inhibition zone of Robusta coffee bean extract and the inhibitory power at each concentration (p<0.05). The concentration that has the highest inhibition is the concentration of 500 mg/ml. Conclusion: It can be said that there is an effectiveness of robusta coffee bean extract in reducing Staphylococcus epidermidis bacteria because the specified concentration inhibition zone is obtained.

In vitro cholesterol-lowering activity of probiotics isolated from commercial products in Medan City Komala, William; Fachrial, Edy; Lister, Clarissa
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 2 (2024): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i2.6378

Regular consumption of probiotic drinks has been shown to provide numerous benefits for human health. One of the primary benefits is boosting the immune system by promoting optimal digestive health. Ten brands of probiotic milk were collected, and bacterial isolates were obtained through a series of isolation and purification steps. The characterization of these isolates involved morphological and biochemical tests, including Gram staining, catalase activity assessment, and tolerance testing under simulated gastric conditions. The cholesterol-lowering activity of the isolates was evaluated in vitro by assessing their ability to reduce cholesterol levels in a simulated intestinal environment. The results demonstrated the presence of potential probiotic strains with cholesterol-lowering activity, providing a foundation for further research into the development of functional dairy products with cholesterol-lowering properties. The results indicated that probiotic milk from commercial beverages demonstrated a favorable response to bile salts in individuals with high cholesterol levels. Probiotic bacteria, such as Lactobacillus acidophilus, can survive in bile, facilitating the deconjugation of bile salts. This suggests that regular consumption of probiotic milk may aid in managing cholesterol levels in individuals with unhealthy lipid profiles. A significant relationship exists between the tolerance of probiotic milk to the digestive environment and its effectiveness in managing cholesterol. Mechanisms including bile salt deconjugation, short-chain fatty acid (SCFA) production, and increased cholesterol excretion contribute to cholesterol management. With appropriate formulation, probiotic milk can effectively control cholesterol levels, particularly in individuals at risk for cardiovascular disease.

Factors influencing work productivity among employees at the Aceh Provincial Health Office Israknur, Israknur; Ginting, Johannes Bastira; Siregar, Santy Deasy; Putri, Lenni Dianna; Sitanggang, Holan Dianju Melva Meinaria; Lister, Clarissa; Harahap, Alvin Abrar
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6676

Productivity is a critical measure of individual performance, particularly in the healthcare sector, where human resources play a pivotal role in achieving organisational and national development goals. This study examines the factors influencing work productivity among employees at the Aceh Provincial Health Office, focusing on education, motivation, discipline, work ethic, and work attitude. Using a descriptive quantitative approach with a cross-sectional design, data were collected from 100 employees through observation, interviews, and questionnaires. Univariate and bivariate analyses, including chi-square tests, were employed to assess the relationships between variables. The results indicate that 68% of employees demonstrated good work productivity. Motivation, discipline, work ethic, and work attitude showed statistically significant positive correlations with productivity (p = 0.000). Specifically, 95.2% of highly motivated employees exhibited good productivity, compared to only 25.2% of those with poor motivation. Similarly, 98.8% of disciplined employees and 81.5% of those with a strong work ethic demonstrated good productivity. A positive work attitude also correlated strongly with productivity (78.0% vs. 61.0% for negative attitudes). However, education level did not significantly influence productivity (p = 0.391), with 80% of highly educated and 66.7% of less educated employees showing good productivity. These findings highlight the importance of fostering motivation, discipline, work ethic, and positive work attitudes to enhance productivity in healthcare settings. While education level was not a significant factor, addressing the other variables can create a conducive work environment and improve service quality. This study underscores the need for organisations to prioritise these factors through incentives, recognition, and professional development opportunities to achieve optimal productivity and organisational success.

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