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All Journal Jurnal Kartika Kimia Jurnal Ilmiah Farmako Bahari Indonesian Journal of Biological Pharmacy
Shafa, Nafis
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology

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EXPLORATION OF CHITINOLYTIC MICROORGANISMS FROM SEAWATER AS ANTI-CANDIDIASIS AGENTS USING FUNCTIONALIZED CHITIN SUBSTRATE DERIVED FROM GREEN MUSSEL WASTE Adnyanaschah, Rahadhyan; Ismail, Dzava Prawinsyah Fairus; Mahardika, Bintang Satrio; Putri, Yolla Adellia; Shafa, Nafis; Rostinawati, Tina
Jurnal Ilmiah Farmako Bahari Vol 16 No 1 (2025): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v16i1.41855

Abstract

Candidiasis is a Candida sp. infection (Candida albicans in common) that happens in nails, hairs, skin, and oesophagus, with around 20-25% prevalence in Indonesia. Chitin is one of the main components of its cell wall and serves as a target for candidiasis therapy using natural degradant compounds, such as chitinase enzyme. Chitinase enzyme is collected from chitinolytic bacteria found massively in chitin-rich environments like seawater. The screening is needed to identify the varieties of bacteria with chitinolytic activity. The screening was done using green mussel waste (Perna viridis), which contains 14-35% chitin and reached 10.776,75 tons of trash in 2020. This research aims to get a chitinolytic bacteria using green mussels as a chitin substrate source and a chitinolytic bacteria with anti-candidiasis activity. This research was conducted by isolating chitin from green mussel shells, chitinolytic bacteria screening, and anti-candidiasis activity test. Results collected from 5.00, 5.08, and 5.18 km isolates were the Vibrio alginolyticus, Vibrio neocaledonicus, and Marinobacter persicus species, which had a chitinolytic index of 1.246, 1.560, 1.492 also 64.29; 61.30; 69.01 U/ml chitinase enzymatic activity. The highest anti-candidiasis activity was found in a sample 5,18 km from the coast of Kejawanan Beach based on the number of chitinase enzyme activity and the chitinolytic index.  
The Bioactive Constituents of Piper aduncum L. as Estrogen Receptor-α Inhibitors: in silico studies Shafa, Nafis; Lathifah, Salma Sri; Alifa, Zahra; Syahid, Muhammad; Ismail, Dzava Prawinsyah Fairus; Mahardika, Bintang Satrio; Novitasari, Dhania
Indonesian Journal of Biological Pharmacy Vol 5, No 3 (2025): IJBP (Desember)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v5i3.69270

Abstract

Wild betel (Piper aduncum L.) is a traditional medicinal plant with reported anticancer potential, particularly against breast cancer. Breast cancer remains a leading cause of cancer-related mortality worldwide, largely driven by estrogen receptor alpha (ERα)–mediated tumor growth. This study aimed to evaluate the potential of bioactive compounds from P. aduncum as ERα inhibitors using an in silico approach. Twenty compounds identified from P. aduncum were assessed for drug-likeness and ADMETox properties, followed by pharmacophore modeling and molecular docking against ERα. Phlorizin, linalool, and phloretin exhibited the highest pharmacophore fit scores, with the optimal model demonstrating strong predictive performance (AUC = 0.95). Among these compounds, phlorizin showed the strongest binding affinity for ERα (−10.38 kcal/mol), with a predicted inhibition constant of 24.77 µM, forming key interactions with GLU353, ALA350, and LEU525, comparable to those of the reference ligand 4-hydroxytamoxifen. Overall, these findings indicate that P. aduncum–derived compounds, particularly phlorizin, phloretin, and linalool, are promising ERα inhibitor candidates and merit further experimental validation for breast cancer therapy.
Molecular Docking and ADMET Analysis of Flavonoid Compounds from Bajakah Tampala Stem (Spatholobus littoralis Hassk.) Targeting VEGFR-2 and c-MET Ismail, Dzava Prawinsyah Fairus; Shafa, Nafis; Pendy, Violent Irene; Devon, George Patrick; Yun, Yenny Febriani
Jurnal Kartika Kimia Vol 8 No 2 (2025): Jurnal Kartika Kimia (In Progress)
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v8i2.982

Abstract

Cancer is a condition marked by abnormal and uncontrolled cell growth, with VEGFR-2 and c-MET receptors contributing to tumor angiogenesis, metastasis, and resistance to therapy. Bajakah tampala stem (Spatholobus littoralis Hassk.) is a traditional plant from Kalimantan that is rich in flavonoid compounds that may interact with these molecular targets. This study aimed to evaluate the molecular interactions, drug-likeness, and pharmacokinetic properties of Bajakah flavonoid compounds through in silico approaches. Lipinski's rule of five and ADMET predictions indicated favorable drug-likeness and absorption profiles for most compounds, although some displayed moderate intestinal absorption and potential mutagenicity. Among the evaluated compounds, hesperetin showed the most favorable predicted binding affinity toward VEGFR-2 (binding energy -9.57 kcal/mol; predicted Ki 97.00 nM), while apigetrin demonstrated the lowest predicted binding energy toward c-MET (-9.43 kcal/mol; predicted Ki 122.94 nM). Both compounds exhibit interactions comparable to reference drugs cabozantinib and crizotinib, suggesting their potential as natural lead compounds for anticancer therapy. Further in vitro and in vivo studies are warranted to confirm their efficacy and safety.
Co-Authors Adnyanaschah, Rahadhyan Alifa, Zahra Devon, George Patrick Dhania Novitasari Ismail, Dzava Prawinsyah Fairus Lathifah, Salma Sri Mahardika, Bintang Satrio Muhammad Syahid Pendy, Violent Irene Putri, Yolla Adellia Tina Rostinawati Yenny Febriani Yun, Yenny Febriani