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All Journal The Journal of Society Medicine (JSOCMED) Media Dermato-Venereologica Indonesiana
Finarsih ES, Ella
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Comparison of Adiponectin Levels in Patients with Familial and Non-Familial Keloid History Finarsih ES, Ella; Putra, Imam Budi; Wardani, Meidina Kesuma
Journal of Society Medicine Vol. 4 No. 1 (2025): January
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i1.188

Abstract

Introduction: Keloid is an abnormal wound healing condition influenced by various factors, including adiponectin levels and genetic predisposition. The role of adiponectin in keloid formation, particularly concerning familial and non-familial history, remains unclear. This study aims to compare adiponectin levels in keloid patients with and without a familial history of keloid formation. To compare adiponectin levels in patients with familial and non-familial keloid history. Methods: This observational analytic study utilized a cross-sectional design involving 40 keloid patients. Participants underwent anamnesis, dermatological examination, and blood sampling to measure serum adiponectin levels using enzyme-linked immunosorbent assay (ELISA). Data were analyzed descriptively using IBM SPSS Statistics version 21. Results: Keloid was more frequently observed in female patients, particularly in the 18–25-year age group. The mean serum adiponectin level among all participants was 11.01±8.34 μg/ml. In patients with a familial history of keloid, 40.0% had low adiponectin levels, while 42.5% of those without a familial history also exhibited low levels. Statistical analysis revealed no significant difference in adiponectin levels between the two groups, suggesting that low adiponectin levels are a common feature in keloid patients regardless of genetic predisposition. Conclusion: Low adiponectin levels are prevalent among keloid patients, but they are not significantly associated with a familial history of keloid formation. Further research is needed to explore the mechanisms linking adiponectin to keloid development.
DNA Salmon sebagai Agen Biostimulator dalam Peremajaan Kulit Finarsih ES, Ella; Jusuf, Nelva Karmila
Media Dermato-Venereologica Indonesiana Vol 53 No 1 (2026): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v53i1.614

Abstract

   Penuaan kulit merupakan proses biologis kompleks yang melibatkan perubahan struktural dan fungsional pada tingkat seluler dan molekuler. Faktor intrinsik yaitu genetik dan metabolisme serta faktor ekstrinsik misalnya paparan sinar ultraviolet berperan dalam percepatan degradasi matriks ekstraseluler melalui peningkatan stres oksidatif dan aktivasi metaloproteinase. Perkembangan dermatologi estetika modern menunjukkan wpergeseran pendekatan terapi dari sekadar koreksi volumetrik menuju stimulasi regenerasi jaringan secara fisiologis. Salah satu agen biostimulator yang menjanjikan adalah polydeoxyribonucleotide (PDRN) yang berasal dari deoxyribonucleic acid (DNA) ikan salmon. Tinjauan pustaka ini bertujuan membahas mekanisme kerja, indikasi klinis, cara aplikasi, keamanan, serta bukti ilmiah terkini penggunaan DNA salmon untuk peremajaan kulit. Literatur menunjukkan bahwa PDRN bekerja terutama melalui aktivasi reseptor adenosin A2A yang memicu peningkatan sintesis kolagen, angiogenesis, efek antiinflamasi, serta modulasi stres oksidatif. Berbagai studi eksperimental dan klinis mendukung peran PDRN sebagai agen regeneratif dengan profil keamanan yang baik. DNA salmon berpotensi menjadi pilihan terapi yang efektif dan aman dalam peremajaan kulit berbasis biostimulasi. 
Co-Authors Jusuf, Nelva Karmila Putra, Imam Budi Wardani, Meidina Kesuma