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All Journal Journal of Comprehensive Science The Journal of Society Medicine (JSOCMED)
Wardani, Meidina Kesuma
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Computer Science & IT Economics, Econometrics & Finance Electrical & Electronics Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience

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Comparison of Adiponectin Levels in Patients with Familial and Non-Familial Keloid History Finarsih ES, Ella; Putra, Imam Budi; Wardani, Meidina Kesuma
Journal of Society Medicine Vol. 4 No. 1 (2025): January
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i1.188

Abstract

Introduction: Keloid is an abnormal wound healing condition influenced by various factors, including adiponectin levels and genetic predisposition. The role of adiponectin in keloid formation, particularly concerning familial and non-familial history, remains unclear. This study aims to compare adiponectin levels in keloid patients with and without a familial history of keloid formation. To compare adiponectin levels in patients with familial and non-familial keloid history. Methods: This observational analytic study utilized a cross-sectional design involving 40 keloid patients. Participants underwent anamnesis, dermatological examination, and blood sampling to measure serum adiponectin levels using enzyme-linked immunosorbent assay (ELISA). Data were analyzed descriptively using IBM SPSS Statistics version 21. Results: Keloid was more frequently observed in female patients, particularly in the 18–25-year age group. The mean serum adiponectin level among all participants was 11.01±8.34 μg/ml. In patients with a familial history of keloid, 40.0% had low adiponectin levels, while 42.5% of those without a familial history also exhibited low levels. Statistical analysis revealed no significant difference in adiponectin levels between the two groups, suggesting that low adiponectin levels are a common feature in keloid patients regardless of genetic predisposition. Conclusion: Low adiponectin levels are prevalent among keloid patients, but they are not significantly associated with a familial history of keloid formation. Further research is needed to explore the mechanisms linking adiponectin to keloid development.
Sensitivity of Fluconazole on Candida Species that Cause Onychomycosis at Haji Adam Malik Hospital Medan Wardani, Meidina Kesuma; Mustika, Arzia
Journal of Comprehensive Science Vol. 4 No. 7 (2025): Journal of Comprehensive Science
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jcs.v4i7.3420

Abstract

Onychomycosis is an infection of the nail component caused by a fungal. Fungal groups that play a role are dermatophytes, non-dermatophytes, and candida. Fluconazole is a commonly used antifungal for onychomycosis caused by Candida spp. To determine the sensitivity of fluconazole on candida species that cause onychomycosis. This in vitro experimental study employed a consecutive sampling method and involved 30 patients presenting clinical features of onychomycosis. Each participant underwent anamnesis, physical and dermatological examinations, followed by nail specimen collection, which was sent to the Clinical Microbiology Laboratory. Initial examination was performed using a 20% KOH solution, followed by fungal culture and fluconazole sensitivity testing. Data analysis was conducted using the Kruskal–Wallis test. Ethical approval was obtained from the Research Ethics Committee of University of North Sumatra and H. Adam Malik Hospital. Candida onychomycosis was more common in women (80%), mostly aged 36–55 years (66.7%), and frequently found in janitors and assistants (40%). Negative KOH results occurred in 76.7% of cases. Candida albicans was the most prevalent species (53.3%), and 96.7% of isolates were sensitive to fluconazole. There were significant differences in fluconazole sensitivity based on culture results (p=0.039). There was found that fluconazole is sensitive to onychomycosis caused by candida species.
Co-Authors Finarsih ES, Ella Mustika, Arzia Putra, Imam Budi