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All Journal Prosiding Seminar Informasi Kesehatan Nasional Journal of Health Research and Technology
Safitri, Rani Safitri
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Effect of Probiotic Lactobacillus Casei on Secretory Immunoglobulin A (S-IgA) Levels in Rats Norvegicus Strain Wistar Post Ovariectomy Safitri, Rani Safitri; Wijayanti, Tut Rayani Aksohini; Alim, Zainal
Journal of health research and technology Vol. 3 No. 1 (2025): Journal of health research and techonology
Publisher : Sahabat Publikasi Kuu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58439/jhrt.v3i1.244

Abstract

Estrogen causes the growth of lactobacillus colonies in the vagina which convert glycogen in superficial vaginal cells into lactic acid, resulting in a low vaginal pH which can inhibit the invasion of pathogenic bacteria. After menopause, lactobacillus growth is inhibited, vaginal secretions become thin, vaginal pH increases and the immune system becomes low. This study aims to determine the effect of Lactobacillus Casei extract on secretory immunoglobulin A levels and reduce vaginal acidity levels (pH) and increase the number of beneficial bacteria in the vaginal mucosa. The research design used was an experimental study with a post-test-only control group design using 24 female rats aged 8-10 weeks with a weight of 180-220 grams. Before treatment, the rats were ovariectomized, and the acclimation period was 14 days, then divided into 4 groups, namely: (K) without treatment, P1 received Lactobacillus Casei extract at a dose of 2ml / rat, P2 at a dose of 2.25ml / rat, and P3 at a dose of 2.5ml / rat. Lactobacillus Casei extract was given orally for 14 days. On the 15th day all rats were terminated. Vaginal acidity levels were measured using the swab method and IgA was measured using the ELISA method, while for bacterial identification tests, gram-positive staining was performed. The results of the one-way ANOVA test showed that Lactobacillus Casei extract can increase IgA levels and significantly reduce vaginal acidity levels by p = 0.003 and p = 0.000. The decrease in acidity levels is due to the deordelin bacillus which converts glycogen into lactic acid so that the vagina remains acidic, as well as the role of S-IgA on the surface of the vaginal mucosa which functions as an opsonin and APC (antigen-presenting Cell) to inhibit the growth of pathogenic bacteria in the vagina. This study concludes that the administration of Lactobacillus Casei extract can increase secretory Immunoglobulin A (S-IgA) levels and reduce vaginal acidity (pH) to normal.
PENGARUH MODEL SHARE DESICION-MAKING PADA AKSEPTOR LAMA AKDR TERHADAP ANGKA DROP OUT KONTRASEPSI Safitri, Rani Safitri; Zainal Alim
Prosiding Seminar Informasi Kesehatan Nasional 2022 : SIKesNas 2022
Publisher : Fakultas Ilmu Kesehatan Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (168.565 KB) | DOI: 10.47701/sikenas.vi.1633

Abstract

Model pengambilan keputusan dalam kesehatan dapat mempengaruhi keputusan yang diberikan oleh pasien dalam pemilihan metode kontrasepsi, salah satunya adalah dengan menggunakan Model shared decision-making (SDM). Model shared decision-making (SDM) adalah salah satu model yang dapat digunakan oleh penyedia pelayanan kesehatan dalam membantu pasien membuat keputusan Kesehatan. Desain penelitian Pre-eksperimental design menggunakan bentuk One Group Pretest – Posttest. Sampling dalam penelitian ini Purposive  sampling. Total responden 60 orang, terbagi dalam 2 kelompok, yaitu kelompok perlakuan 30 responden dan kelompok kontrol 30 responden. Berdasarkan hasil penelitian menunjukkan pada kelompok perlakuan  bahwa setelah diberikan metode SDM   27 responden tingkat pengetahuan baik (77,14%), sebagian kecil dari 2 responden tingkat pengetahuan cukup moderat (17,5%) dan persentase kecil dari 1 responden tingkat pengetahuan kurang (5,36%). Sedangkan pada kelompok kontrol diperoleh hampir seluruhnya dengan tingkat pengetahuan cukup 34 responden (97%) dan persentase kecil 1 responden dengan tingkat pengetahuan kurang (3%). Analisis data dengan uji Wilcoxon diperoleh nilai signifikansi sebesar 0,006 (p < 0,05) yang artinya ada pengaruh pemberian metode SDM  terhadap angka Drop out kontrasepsi AKDR. Hasil penelitian ini diharapkan dapat dijadikan suatu inovasi sebagai metode yang baru dalam pengambilan keputusan ber KB. Kata Kunci: Share Decision-Making, Akseptor Lama AKDR, Angka Drop Out
Co-Authors Alim, Zainal Tut Rayani Aksohini Wijayanti Zainal Alim