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Cytotoxic and Antiproliferative Effects of Gynura divaricata Ethanolic Extract on HCT-116 Colorectal Cancer Cells In Vitro Putri Rifai, Fauziah Novita; Hidayah, Nurul; Sakinah, Feby Nur; Adityani, Resanti
International Journal of Cell and Biomedical Science Vol 3 No 8 (2024)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v3i8.50

Abstract

Background: Colorectal cancer is a major cause of cancer-related morbidity and mortality worldwide. The limitations of conventional treatments such as chemotherapy and radiotherapy have driven the search for alternative therapies with fewer side effects. Objective: This study aimed to investigate the cytotoxic effects of Gynura divaricata extract on HCT-116 colorectal cancer cells and evaluate its potential as a complementary anticancer agent. Methods: Gynura divaricata was extracted using ethanol through a maceration process. HCT-116 cells were cultured and treated with various concentrations of the extract. Cell viability was measured using the MTT assay, and the IC50 value was calculated through linear regression analysis. Results: Treatment with Gynura divaricata extract resulted in a dose-dependent decrease in cell viability. The IC50 value was determined to be 62.09 µg/mL, indicating significant cytotoxic activity against HCT-116 cells. Conclusion: Gynura divaricata exhibits potential as an alternative or adjunctive therapy for colorectal cancer due to its ability to reduce cancer cell viability.
Ultra-wideband diamond-shaped metamaterial absorber for radar cross section reduction Defrianto Defrianto; Erwin Kurnia; Saktioto Saktioto; Tengku Emrinaldi; Feby Nur Sakinah; M Ikhsan; Vepy Asyana; Yan Soerbakti
Science, Technology, and Communication Journal Vol. 6 No. 2 (2026): SINTECHCOM Journal (February 2026)
Publisher : Lembaga Studi Pendidikan dan Rekayasa Alam Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59190/stc.v6i2.340

Abstract

This study presents the design and full-wave simulation of a diamond-shaped metamaterial absorber configured in a 4×4 array for applications in radar cross section reduction (RCSR). The structure was modeled on an FR-4 substrate with a copper patch and metallic ground plane to achieve high absorption across the ultra-wideband (UWB) frequency range of 0.09 – 10 GHz. Simulations were conducted using CST Studio Suite. Key radar-related performance parameters including reflection (S11), transmission (S21), and absorption were analyzed. Results indicate that the absorber achieves extremely low reflection values (return loss up to -85 dB), near-zero transmission due to the ground plane, and absorption exceeding 80% in targeted radar bands. These findings demonstrate the high potential of diamond-shaped metamaterial absorbers for stealth applications and electromagnetic wave attenuation in modern radar systems.