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All Journal Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Erika Kusumawardani
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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HUBUNGAN PENGGUNAAN KONTRASEPSI HORMONAL DENGAN KEJADIAN STROKE Yusmahenry Galindra; Erika Kusumawardani; Aulia Cesarany
Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Vol 15 No 1 (2025): Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37776/zked.v15i1.1666

Abstract

ABSTRACT Background: Stroke is a condition characterized by local and global neurological disorders that can progress, continue for more than 24 hours, and result in death. One of the risk factors for stroke is the use of contraception. Hormonal contraceptives containing estrogen and progesterone can significantly change the coagulation system by increasing the activity of thrombin and clotting factors and reducing the action of natural anticoagulants. Methods: : This type of research uses the Case Control method with an analytical observational approach. The study population was all stroke sufferers recorded in the medical records at RSBK in 2023, totaling 155 patients. This study used a sample of 80 patients. Where 40 patients were controls and 40 patients were cases. Results: The results of the Chi-Square analysis test show that the use of hormonal contraceptives is not related to the incidence of stroke at Budi Kemuliaan Hospital, Batam City in 2023 with a value of p=0.70 (>0.05). Conclusion: Based on the research results, it was found that there was no significant relationship between the use of hormonal contraception and the incidence of stroke at Budi Kemuliaan Hospital, Batam City in 2023. Keywords: Hormonal Contraception, Stroke, Used
HUBUNGAN ANTARA EKSPRESI CASPASE 3 DENGAN PROGRESIVITAS KANKER SERVIKS STADIUM IIA2 DAN IIB POST KEMOTERAPI NEOADJUVAN RSUP DR SARDJITO YOGYAKARTA Erika Kusumawardani; Muhammad Ali Sabisi
Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Vol 15 No 2 (2025): Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37776/zked.v15i2.1817

Abstract

ABSTRAK LATAR BELAKANG: Kanker serviks merupakan salah satu kanker pada perempuan yang memiliki angka kejadian dan kematian yang tinggi di Indonesia. Pada kanker serviks stadium IIA2 dan IIB dikenal modalitas kemoterapi neoadjuvan sebelum operasi radikal yang bertujuan untuk mengurangi massa tumor sehingga memudahkan pembedahan dan menghambat mikrometastasis. Infeksi Human Papilloma Virus (HPV) merupakan faktor penting penyebab kanker serviks. Protein caspase 3 yang berperan dalam proses apoptosis berkaitan dengan patogenesis kanker serviks. Sampai saat ini, belum ada prediktor yang dapat digunakan untuk memprediksi progresivitas kanker serviks stadium IIA2 dan IIB setelah pemberian kemoterapi neoadjuvan. BACKGROUND: Cervical cancer is a cancer in women that has a high incidence and mortality in Indonesia. In stage IIA and IIB cervical cancer, neoadjuvant chemotherapy modality is known before radical surgery which aims to reduce tumor mass to facilitate surgery and inhibit micrometastatic. Human Papilloma Virus (HPV) infection is an important factor in causing cervical cancer. Caspase 3 protein which plays a role in the apoptosis process related to the pathogenesis of cervical cancer. Nowadays, there are no predictors that can be used to predict the progresivity of stage IIA2 and IIB cervical cancer after presenting neoadjuvant chemotherapy. Kata kunci: kanker, serviks, caspase 3, progresivitas, kemoterapi
Co-Authors Aulia Cesarany Muhammad Ali Sabisi Yusmahenry Galindra