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All Journal CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Eduvest - Journal of Universal Studies Surabaya Biomedical Journal
Danny W. Danandjaja
Fakultas Kedokteran, Universitas Hang Tuah, Indonesia
Aerospace Engineering Computer Science & IT Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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PENGARUH TERAPI OKSIGEN HIPERBARIK TERHADAP DERAJAT PEMULIHAN TULI MENDADAK Dhiya Shafa Arwinto; Danny W. Danandjaja; Sihning E. J. Tehupuring; Prijanti Eka Poerwantiningroem
Surabaya Biomedical Journal Vol. 5 No. 3 (2026): May
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/v5i3.197

Abstract

Tuli mendadak merupakan kondisi kegawatdaruratan pada sistem pendengaran yang ditandai dengan penurunan pendengaran secara tiba-tiba, dan salah satu terapi yang berkembang saat ini adalah terapi oksigen hiperbarik (TOHB) yang bertujuan meningkatkan suplai oksigen ke koklea sehingga diharapkan dapat membantu proses perbaikan fungsi pendengaran. Penelitian ini bertujuan menilai perubahan ambang pendengaran pada pasien tuli mendadak sebelum dan sesudah pemberian TOHB dengan menggunakan rancangan observasional analitik dan pendekatan retrospektif. Data diperoleh dari rekam medis pasien dengan diagnosis tuli mendadak di RSPAL dr. Ramelan Surabaya periode Januari 2022 hingga Agustus 2025, dengan total 12 pasien dan 18 telinga yang memenuhi kriteria inklusi. Data yang dianalisis meliputi karakteristik pasien, derajat ketulian sebelum dan sesudah TOHB, serta perubahan ambang pendengaran berdasarkan klasifikasi Siegel. Karena data tidak berdistribusi normal berdasarkan uji Shapiro–Wilk, analisis perbedaan nilai pre dan post dilakukan menggunakan uji Wilcoxon Signed-Rank Test. Hasil penelitian menunjukkan bahwa setelah pemberian TOHB, sebagian besar telinga mengalami perbaikan ambang pendengaran, dengan 12 telinga (66,7%) mengalami penurunan nilai pure tone average (PTA), 4 telinga (22,2%) tidak mengalami perubahan, dan 2 telinga (11,1%) mengalami peningkatan nilai PTA. Uji Wilcoxon menunjukkan nilai p = 0,008 (p < 0,05), yang menandakan adanya perbedaan bermakna antara nilai PTA sebelum dan sesudah TOHB, sehingga dapat disimpulkan bahwa TOHB memiliki efek yang signifikan dalam membantu pemulihan pendengaran pada pasien tuli mendadak.
The In silico Study: Curcumin Potential As A Topoisomerase Enzyme Inhibitor in The Replication Process of Plasmodium Falciparum That Causes Cerebral Malaria Any Fira Safitri; Risma Risma; Olivia Mahardani Adam; Danny W. Danandjaja
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.50044

Abstract

Turmeric (Curcuma longa) contains the active compound curcumin, which has antiprotozoal, antimalarial, anti-inflammatory effects. This study aims to ignite the potential of curcumin, which has the potential as an antiprotozoal through inhibition of Plasmodium Falciparim replication through the topoisomerase enzyme. The method used in this study is the One Shot Experimental Study, with several stages including preparation of active compounds, prediction of active substance binding energy, prediction of compound binding, molecular docking, prediction of ADME (absorption, distribution, metabolism, excretion) and toxicity. The results show that curcumin binds to the same site as Artemisinin, both also interact with the topoisomerase VI protein and provide similar inhibitory effects. ADME predictions show that curcumin has good potential for use as an oral drug, with both LD50s included in class 4. The binding affinity and bioactivity of curcumin are lower than Artemisinin but are still considered to have the potential as a safer antiprotozoal alternative.
Breaking The Cycle: Maternal Knowledge, Sanitation, dan Diarrhea Prevention in Toddlers widya fadhilascha; Danny Wresniwira Danandjaja; Ronald Pratama Adiwinoto; Retno Wisanti
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 6 No. 3 (2026): Februari
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v6i3.326

Abstract

This research aims to explore the relationship between maternal knowledge and sanitation hygiene with the incidence of diarrhea in young children within the Socah Community Health Center's service area. The study employs a quantitative approach with an observational cross-sectional design. Primary data was gathered using a questionnaire assessing maternal knowledge and daily sanitation hygiene practices. Data analysis was conducted using both univariate and bivariate methods, including the chi-square test. The findings reveal that, among 101 mothers with toddlers who met the inclusion criteria, most had low knowledge (40.6%) and moderately implemented hygiene and sanitation practices (37.6%). Additionally, 47.5% of the children had experienced diarrhea in the past two weeks. The chi-square test showed a significant correlation between maternal knowledge and the occurrence of diarrhea (p < 0.001), as well as between hygiene and sanitation practices and the incidence of diarrhea in children (p < 0.001). The study concludes that both maternal knowledge and sanitation hygiene significantly affect the occurrence of diarrhea in children in the Socah Community Health Center area. It is recommended that health education regarding diarrhea prevention, personal hygiene, and environmental sanitation be enhanced to reduce diarrhea rates among infants. This research is intended to serve as a foundation for the planning of health support and prevention programs in the Community Health Center's service area.
Co-Authors Any Fira Safitri Dhiya Shafa Arwinto Olivia Mahardani Adam Prijanti Eka Poerwantiningroem Retno Wisanti Risma Ronald Pratama Adiwinoto Sihning E. J. Tehupuring widya fadhilascha