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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Medical and Health Science Journal Oceana Biomedicina Journal Hang Tuah Medical Journal Eduvest - Journal of Universal Studies
Risma
Fakultas Kedokteran Universitas Hang Tuah
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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The Effect of Thespesia populnea Against Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase Receptor by Study In Silico I Made Prasetya Kurniawan; Prawesty Diah Utami; Risma Risma
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.5368

Abstract

Indonesia is a country that has abundant natural resources; one of them is the Baru laut plant which is the latest breakthrough because it has an active substance that can be used as an anti-malaria medicine. It is very beneficial because there has been a case of resistance of artemisinin derivatives in Indonesia. The purpose of this study was to determine the potential of active compounds in Baru laut plants (Thespesia populnea (L.) Soland ex. Correa) against the Plasmodium falciparum enoyl acyl carrier protein reductase receptor in P. falciparum through in silico studies. This research is purely experimental using the One-Shot Experimental Study research design method. Observations were only made once between the variables studied through three analyzes, namely prediction analysis of active compound content, prediction analysis of the mechanism of action of active compound content, and prediction analysis of ADME active compound. The study results show that there are three active compounds in Baru laut plants that have antimalarial potential. The three compounds include gossypol, linoleic acid, and beta-sitosterol, have their respective potential in becoming a malaria drug. This study concludes that Baru laut plants have potential as anti-malaria drugs.
Prevalence of Trichomoniasis in Cervical Cancer Patients Luh Putu Diah Ayuning; Risma Risma; Prawesty Diah Utami
Jurnal Ilmu Kesehatan dan Kesehatan Vol 6 No 1 (2022): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v6i1.2543

Abstract

Backgroud: Trichomoniasis is the most frequent non-viral sexually transmitted disease in the world, and it can lead to persistent HPV infection. Trichomonas vaginalis infection causes damage to the vaginal mucosa, activation of oncogenes and inactivation of tumor suppressor proteins, and production of non-specific oxidants that lead to cervical cancer. This study aims to determine the prevalence of trichomoniasis in cervical cancer patients. Methods: This study uses systematic literature review method and uses 10 international journals obtained through machine learning and indexed in Scimago.  Journals are screened through PRISMA and have gone through a critical appraisal process.This study took place from April to September 2021.  Results: The prevalence of trichomoniasis in cervical cancer patients ranged from 0.022% to 87.7%, according to the findings of this study. The prevalence results vary due to differences in demographics and diagnostic methods used. Statistical analysis of the association between trichomoniasis and cervical cancer varied between significant and insignificant. Differences in the association are influenced by the research design used, diagnostic methods, and sample of the research. Conclusions: The conclusion of this study is that the prevalence of trichomoniasis in cervical cancer patients was discovered to be the highest in the study by Ghosh et al. in Kolkata, India (72.6% women with CIN 1, 71.0% women with CIN 2 or CIN 3, and 87.7% women with invasive cancer) and the lowest in the study by Su et al.  in Taiwan (0.022%). The association between trichomoniasis and cervical cancer was found to be varied.
Manalagi Apple Vinegar (Malus sylvestris Mill) as Anti Diabetic to Alloxan Induced Wistar White Male Rat Valentina Verrel Purnomo; A. Sareh Arjono Tjandra; Risma Risma
Denta Journal Kedokteran Gigi Vol 2 No 1 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 1 January - June 2019
Publisher : Universitas Hang Tuah

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Abstract

Apple vinegar is estimated to be able to cure diabetes. Vinegar is able to control the increase of glicemic index. Apple has antioxidant substance such as quercetin and chlorogenic acid. Manalagi apple could be found easily in Indonesia.This research aims to reveal the effect of Manalagi apple vinegar (Malus sylvestris Mill) towards blood glucose level of alloxan induced Wistar white male rats (Rattus norvegicus).This research is experimental laboratory using Experimental methods. The samples are 30 white rats divided into three groups for 31 days, 1) group which only given standard diet; 2) group that induced by 120mg/dL alloxan; 3) group that induced by 120mg/dL alloxan and Manalagi apple vinegar 0.27ml/100gram weight for 14 days. The measurement of blood serum glucose level is done on day twenty four using homogenous colorimetric enzymatic test method for all groups.Blood glucose average in group with only given standard diet as negative control group (182.33 mg/dL), group which induced by 120mg/dL alloxan as positive control group (205.2 mg/dL), group which induced by 120mg/dL alloxan and Manalagi apple vinegar as treatment group (212.25 mg/dL). The result of One-Way Anova significance is 0.229.The conclusion of this research is that Manalagi apple vinegar treatment doesn’t able to decrease the blood glucose level of white Wistar male rats significantly.
Efek Pemberian Infusa Daun Carica papaya Terhadap Perkembangan Vektor Larva Nyamuk Aedes aegypti VINA LIDYA SETJAPUTRA; STEVEN CHRISTIAN SUSIANTO; RISMA
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v20i1.183

Abstract

Background: Vector eradication is the most effective strategy to prevent Dengue Hemorrhagic Fever, particularly larvae elimination by larvicide. The papaya leaf (Carica papaya) contains several chemicals used as a larvicidal agent. This study aimed to determine the larvicidal activity of papaya leaf (Carica papaya) infusion against third instar Aedes aegypti larvae as dengue hemorrhagic fever prevention. Method: This was an experimental laboratory study with a post-test-only control group design. We used the third instar of Aedes aegypti mosquito larvae, divided into seven treatment groups, one positive control group, and one negative control group, containing 25 larvae each. The treatment groups were given papaya leaf infusion with concentration of 4%, 4,5%, 5%, 5,5%, 6%, 6,5%, 7%, respectively. The negative control group did not receive any treatment, and the positive control group received Temephos with 1 ppm dose. Larvae mortality was recorded after 24 hours, and we replicated the experiment 3 times. The mortality data were analyzed using a one-way ANOVA test for normally distributed and Kruskal Wallis for not normally distributed. Results: There were no significant differences between treatment groups and negative control group, except in concentration of 6,5% (p=0,034) and 7% (p=0,037) group, and significant differences between all treatment groups compared to the positive control group (p<0,05). Conclusion: Papaya leaf infusion as Aedes aegypti larvicide in concentrations of 6,5% and 7% showed a significant effect on larvae mortality after 24-hour. However, compared to Temephos, it was a less larvicidal effect.
The In silico Study: Curcumin Potential As A Topoisomerase Enzyme Inhibitor in The Replication Process of Plasmodium Falciparum That Causes Cerebral Malaria Any Fira Safitri; Risma Risma; Olivia Mahardani Adam; Danny W. Danandjaja
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.50044

Abstract

Turmeric (Curcuma longa) contains the active compound curcumin, which has antiprotozoal, antimalarial, anti-inflammatory effects. This study aims to ignite the potential of curcumin, which has the potential as an antiprotozoal through inhibition of Plasmodium Falciparim replication through the topoisomerase enzyme. The method used in this study is the One Shot Experimental Study, with several stages including preparation of active compounds, prediction of active substance binding energy, prediction of compound binding, molecular docking, prediction of ADME (absorption, distribution, metabolism, excretion) and toxicity. The results show that curcumin binds to the same site as Artemisinin, both also interact with the topoisomerase VI protein and provide similar inhibitory effects. ADME predictions show that curcumin has good potential for use as an oral drug, with both LD50s included in class 4. The binding affinity and bioactivity of curcumin are lower than Artemisinin but are still considered to have the potential as a safer antiprotozoal alternative.
The Relationship Between Hba1c Levels in Type 2 Diabetes Mellitus Patients and Clinical Manifestations of Diabetic Microangiopathy Neuropathy With The Incidence of Erectile Dysfunction Travesthi Dian Pursetyo; Moh. Fathi Ilmawan; Redemptus Yudadi; Risma Risma
Eduvest - Journal of Universal Studies Vol. 5 No. 5 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i5.50098

Abstract

Type 2 diabetes mellitus is a chronic disease that can lead to various complications. This study aims to analyze the relationship between HbA1c levels and the clinical manifestations of diabetic microangiopathy neuropathy with the incidence of erectile dysfunction in patients with type 2 diabetes mellitus. The objective is to understand the prevalence of the relationship between HbA1c levels, the clinical manifestations of diabetic microangiopathy neuropathy, and the occurrence of erectile dysfunction in patients with type 2 diabetes mellitus. This study used an observational analytical design with a cross-sectional approach. The sample consisted of 61 male patients who underwent examination at RSPAL dr. Ramelan Surabaya from July to September 2024. Data was collected through interviews using the International Index of Erectile Function (IIEF-5) questionnaire, along with secondary data on HbA1c levels and symptoms of diabetic neuropathy. Statistical analysis was performed using the Chi-Square test to identify relationships between the study variables. The results of the study showed a significant relationship between HbA1c levels and the incidence of erectile dysfunction. However, there was no significant relationship between the clinical manifestations of diabetic microangiopathy neuropathy and erectile dysfunction, as indicated by the Chi-Square test. The conclusions of this study are: first, there is a strong relationship between uncontrolled HbA1c levels and the incidence of erectile dysfunction, and second, although the clinical manifestations of diabetic microangiopathy neuropathy are common in patients with type 2 diabetes mellitus, no direct significant relationship was found between the clinical manifestations of diabetic microangiopathy neuropathy and erectile dysfunction.
In Silico Study: the Potential of Apigenin Compounds from Moringa Plants as Inhibitors of Dihydroorotate Dehydrogenase Enzyme of Plasmodium Falciparum in Hepatic Malaria Therapy Helena Elysia Argiyanti; I Dewa Made Widi Hersana; Risma Risma
Eduvest - Journal of Universal Studies Vol. 6 No. 1 (2026): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v6i1.52724

Abstract

Malaria is a global health problem caused by Plasmodium infection, with hepatic malaria representing a serious complication due to liver dysfunction, particularly from Plasmodium falciparum. One promising therapeutic target is the enzyme dihydroorotate dehydrogenase (PfDHODH), which plays a crucial role in the parasite’s de novo pyrimidine synthesis. Moringa oleifera is known to contain various flavonoids with antimalarial and hepatoprotective activities, including apigenin. This study aimed to evaluate the potential of apigenin as an inhibitor of PfDHODH for hepatic malaria treatment using an in silico approach. The research employed a one-shot experimental design involving molecular docking simulations with AutoDock Vina, followed by pharmacokinetic, drug-likeness, and toxicity predictions using SwissADME, pkCSM, and ProTox3. Results showed that apigenin exhibited strong binding affinity to PfDHODH (-8.9 kcal/mol), comparable to the primary control ligand (-9.3 kcal/mol) and higher than artemisinin (-8.7 kcal/mol). Apigenin demonstrated favorable ADME properties, complied with Lipinski’s rule, and was classified as low toxicity (class 5) with no predicted carcinogenic effects. These findings indicate that apigenin from Moringa oleifera has promising potential as a PfDHODH inhibitor and may serve as a candidate for the treatment of hepatic malaria, warranting further experimental validation.
Co-Authors A. Sareh Arjono Tjandra Any Fira Safitri Danny W. Danandjaja Helena Elysia Argiyanti I Dewa Made Widi Hersana I Made Prasetya Kurniawan Luh Putu Diah Ayuning Moh. Fathi Ilmawan Olivia Mahardani Adam Prawesty Diah Utami Redemptus Yudadi STEVEN CHRISTIAN SUSIANTO Travesthi Dian Pursetyo Valentina Verrel Purnomo VINA LIDYA SETJAPUTRA