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All Journal Student Scientific Creativity Journal Jurnal Mahasiswa Ilmu Kesehatan Nian Tana Sikka: Jurnal Ilmiah Mahasiswa
Elsa Trisna Sari
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Agriculture, Biological Sciences & Forestry Arts Humanities Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health Social Sciences

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Journal : Student Scientific Creativity Journal

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Pengaruh Kesakitan pada Nefron Terhadap Terjadinya Penyakit Gagal Ginjal Elsa Trisna Sari; Nur Aini Fatna Fadilla; Tyara Avrilyanti Ghea Indriansyah; Liss Dyah Dewi Arini
Student Scientific Creativity Journal Vol. 3 No. 2 (2025): Student Scientific Creativity Journal
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/sscj-amik.v3i2.5498

Abstract

Nephrons are the smallest functional units in the kidneys that are responsible for filtering blood, regulating fluid balance, and excreting waste through urine. When nephrons are damaged or diseased, kidney function can be significantly impaired. Nephron damage is usually caused by various factors, such as hypertension, diabetes, kidney infections, or certain drug toxicity. In the early stages, nephron damage can cause a decrease in glomerular filtration rate (GFR). As a result, metabolic waste products such as urea and creatinine accumulate in the blood, known as azotemia. Over time, progressive damage to the nephrons can trigger chronic kidney disease (CKD). In more severe cases, when most of the nephrons are no longer functioning, the kidneys lose their ability to maintain the body's homeostasis. This results in electrolyte imbalance, metabolic acidosis, and excess fluid buildup, known as end-stage renal disease (ESRD). At this stage, patients require renal replacement therapy such as dialysis or kidney transplantation to survive. Prevention of nephron damage is very important, including through the management of comorbidities such as diabetes and hypertension, adequate fluid intake, and avoiding exposure to toxic substances that damage the kidneys. Thus, the risk of kidney failure can be minimized.
Studi Toksikologi Biokimia : Dampak Senyawa Beracun Terhadap Proses Metabolisme Seluler dan Kesehatan Manusia David Valentino Iskandar; Karina Sella Juwitasari; Erlanda Islami Pasha; Elsa Trisna Sari; Liss Dyah Dewi Arini
Student Scientific Creativity Journal Vol. 3 No. 2 (2025): Student Scientific Creativity Journal
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/sscj-amik.v3i2.5520

Abstract

Biochemical toxicology studies are disciplines that study the impact of toxic compounds on biochemical processes in the human body. Toxic compounds, whether from the environment, industrial chemicals, drugs, or natural products, can interfere with cellular metabolic mechanisms and potentially cause damage to organs or body systems. This study aims to analyze how toxic compounds interact with biomolecules, such as proteins, enzymes, and nucleic acids, which play a role in cellular metabolic processes. Disruption of metabolic enzymes can affect key metabolic pathways, such as energy synthesis, detoxification, and homeostasis regulation. These toxic impacts can contribute to the development of acute and chronic diseases, including liver, kidney, nervous system disorders, and cancer. In this study, we also discuss the detoxification mechanisms involving enzymes such as cytochrome P450 and glutathione-S-transferase in reducing the toxic effects of these compounds. A deeper understanding of toxic interactions and their impact on cellular metabolism is essential in developing preventive and therapeutic strategies for poisoning or toxicity-related diseases. This research is expected to provide insight into the development of more effective drugs and medical approaches in overcoming the effects of toxic toxins on humans.
Co-Authors Azizah Zahra Nur Fitria Azzahra Nabilla Atha David Valentino Iskandar Erika Dwi Susanti Erlanda Islami Pasha Karina Sella Juwitasari Liss Dyah Dewi Arini Nur Aini Fatna Fadilla Tyara Avrilyanti Ghea Indriansyah