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All Journal Student Scientific Creativity Journal Jurnal Mahasiswa Ilmu Kesehatan Jurnal Riset Ilmu Kesehatan Umum dan Farmasi
Tyara Avrilyanti Ghea Indriansyah
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Arts Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health Social Sciences

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Pengaruh Kesakitan pada Nefron Terhadap Terjadinya Penyakit Gagal Ginjal Elsa Trisna Sari; Nur Aini Fatna Fadilla; Tyara Avrilyanti Ghea Indriansyah; Liss Dyah Dewi Arini
Student Scientific Creativity Journal Vol. 3 No. 2 (2025): Student Scientific Creativity Journal
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/sscj-amik.v3i2.5498

Abstract

Nephrons are the smallest functional units in the kidneys that are responsible for filtering blood, regulating fluid balance, and excreting waste through urine. When nephrons are damaged or diseased, kidney function can be significantly impaired. Nephron damage is usually caused by various factors, such as hypertension, diabetes, kidney infections, or certain drug toxicity. In the early stages, nephron damage can cause a decrease in glomerular filtration rate (GFR). As a result, metabolic waste products such as urea and creatinine accumulate in the blood, known as azotemia. Over time, progressive damage to the nephrons can trigger chronic kidney disease (CKD). In more severe cases, when most of the nephrons are no longer functioning, the kidneys lose their ability to maintain the body's homeostasis. This results in electrolyte imbalance, metabolic acidosis, and excess fluid buildup, known as end-stage renal disease (ESRD). At this stage, patients require renal replacement therapy such as dialysis or kidney transplantation to survive. Prevention of nephron damage is very important, including through the management of comorbidities such as diabetes and hypertension, adequate fluid intake, and avoiding exposure to toxic substances that damage the kidneys. Thus, the risk of kidney failure can be minimized.
Peran Asam Nukleat dalam Proses Sintesis Protein: Analisis Mekanisme DNA, RNA, dan Ribosom dalam Regulasi Genetik Amelia Putri Az Azahra; Pramesti Listanto; Khotimah Nur Ramadhani; Tyara Avrilyanti Ghea Indriansyah; Latifa Alya Khairunnisa; Liss Dyah Dewi Arini
Student Scientific Creativity Journal Vol. 3 No. 2 (2025): Student Scientific Creativity Journal
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/sscj-amik.v3i2.5501

Abstract

Nucleic acids play a vital role in the process of protein synthesis, which is the core of genetic regulation in cells. This process involves a complex mechanism of DNA, RNA, and ribosomes working in a coordinated manner. DNA (deoxyribonucleic acid) functions as a genetic blueprint that stores information for protein synthesis. Through the process of transcription, DNA is transcribed into messenger RNA (ribonucleic acid) (mRNA) in the cell nucleus. mRNA carries the genetic code to the cytoplasm, where ribosomes act as translation centers. Ribosomes, together with transfer RNA (tRNA), read the codon sequence on mRNA to determine the sequence of amino acids that will be assembled into polypeptides. This process, called translation, involves complex interactions between mRNA, tRNA, and ribosomes to ensure that the resulting protein is in accordance with genetic instructions. In addition, the role of non-coding RNA, such as microRNA and riboswitches, is also important in regulating gene expression post-transcriptionally. A deep understanding of the mechanisms of DNA, RNA, and ribosomes has opened up great opportunities in biotechnology and medicine, such as gene therapy and RNA-based drug development. Thus, the analysis of the role of nucleic acids becomes an important foundation in the exploration of molecular biology and genetics.
Pentingnya Mengetahui Golongan Darah Anda: Dampaknya pada Kesehatan dan Kehidupan Sehari-hari Tyara Avrilyanti Ghea Indriansyah; Karina Sella Juwitasari; Margaretha Alesandria Natasya Weka; Pramesti Listanto; Latifa Alya Khairunnisa; Juwita Ramadhani Octavianingrum; Liss Dyah Dewi Arini
Jurnal Mahasiswa Ilmu Kesehatan Vol. 3 No. 3 (2025): Jurnal Mahasiswa Ilmu Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v3i3.2947

Abstract

Knowledge of one’s blood type plays a crucial role in supporting individual health and preparedness in medical emergencies. This literature review explores the relationship between the ABO and Rhesus blood group systems and various health outcomes, including susceptibility to infections, cardiovascular risks, and biochemical implications in personalized medicine. Based on a synthesis of ten scholarly sources, the findings reveal that blood type influences vulnerability to COVID-19, gastrointestinal infections, and elevates cardiovascular disease risk particularly among non-O blood types. These results emphasize the importance of early education and blood type screening as preventive measures. The study also highlights the need for integrating blood type data into national health care systems.
Hubungan antara Kerusakan DNA dan Mekanisme Perbaikan Seluler: Tinjauan Literatur Azizah Zahra Nur Fitria; Margaretha Alesandria Natasya Weka; Azlinatul Lulu Kharolaini; Desi Rahmasari; Pramai Sheila Eka Khoireina; Feni Atika Tsuroyya; Septi Puspita Kurniawati; Tyara Avrilyanti Ghea Indriansyah; Liss Dyah Dewi Arini
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 4 No. 2 (2026): April : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v4i2.972

Abstract

DNA damage is a fundamental biological phenomenon that occurs due to endogenous and exogenous factors such as radiation, chemical exposure, and replication errors. If not properly repaired, DNA damage can lead to genomic instability, mutations, and the development of various diseases, including cancer. This literature review aims to examine the relationship between DNA damage and cellular repair mechanisms in maintaining genomic integrity. The method used in this study is a literature review of national scientific journals that discuss types of DNA damage, molecular markers of DNA damage, and cellular repair pathways. The findings indicate that cells possess complex and coordinated DNA repair systems, including base excision repair, nucleotide excision repair, mismatch repair, and double-strand break repair mechanisms, which play crucial roles in preserving cellular stability. The effectiveness of these repair mechanisms is influenced by the type and extent of DNA damage. Understanding the interaction between DNA damage and repair pathways provides important implications for the development of disease prevention strategies, diagnostic biomarkers, and therapeutic approaches in molecular biology and medical sciences.
Co-Authors Amelia Putri Az Azahra Azizah Zahra Nur Fitria Azlinatul Lulu Kharolaini Desi Rahmasari Elsa Trisna Sari Feni Atika Tsuroyya Juwita Ramadhani Octavianingrum Karina Sella Juwitasari Khotimah Nur Ramadhani Latifa Alya Khairunnisa Liss Dyah Dewi Arini Margaretha Alesandria Natasya Weka Nur Aini Fatna Fadilla Pramai Sheila Eka Khoireina Pramesti Listanto Septi Puspita Kurniawati