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All Journal Student Scientific Creativity Journal Jurnal Mahasiswa Ilmu Kesehatan Nian Tana Sikka: Jurnal Ilmiah Mahasiswa
Nur Aini Fatna Fadilla
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Agriculture, Biological Sciences & Forestry Arts Humanities Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health Social Sciences

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Journal : Student Scientific Creativity Journal

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Pengaruh Kesakitan pada Nefron Terhadap Terjadinya Penyakit Gagal Ginjal Elsa Trisna Sari; Nur Aini Fatna Fadilla; Tyara Avrilyanti Ghea Indriansyah; Liss Dyah Dewi Arini
Student Scientific Creativity Journal Vol. 3 No. 2 (2025): Student Scientific Creativity Journal
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/sscj-amik.v3i2.5498

Abstract

Nephrons are the smallest functional units in the kidneys that are responsible for filtering blood, regulating fluid balance, and excreting waste through urine. When nephrons are damaged or diseased, kidney function can be significantly impaired. Nephron damage is usually caused by various factors, such as hypertension, diabetes, kidney infections, or certain drug toxicity. In the early stages, nephron damage can cause a decrease in glomerular filtration rate (GFR). As a result, metabolic waste products such as urea and creatinine accumulate in the blood, known as azotemia. Over time, progressive damage to the nephrons can trigger chronic kidney disease (CKD). In more severe cases, when most of the nephrons are no longer functioning, the kidneys lose their ability to maintain the body's homeostasis. This results in electrolyte imbalance, metabolic acidosis, and excess fluid buildup, known as end-stage renal disease (ESRD). At this stage, patients require renal replacement therapy such as dialysis or kidney transplantation to survive. Prevention of nephron damage is very important, including through the management of comorbidities such as diabetes and hypertension, adequate fluid intake, and avoiding exposure to toxic substances that damage the kidneys. Thus, the risk of kidney failure can be minimized.
Co-Authors Azizah Zahra Nur Fitria Azzahra Nabilla Atha David Valentino Iskandar Elsa Trisna Sari Erika Dwi Susanti Erlanda Islami Pasha Liss Dyah Dewi Arini Tyara Avrilyanti Ghea Indriansyah