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All Journal Student Scientific Creativity Journal Jurnal Mahasiswa Ilmu Kesehatan
Tyara Avrilyanti Ghea Indriansyah
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Arts Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health Social Sciences

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Journal : Student Scientific Creativity Journal

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Pengaruh Kesakitan pada Nefron Terhadap Terjadinya Penyakit Gagal Ginjal Elsa Trisna Sari; Nur Aini Fatna Fadilla; Tyara Avrilyanti Ghea Indriansyah; Liss Dyah Dewi Arini
Student Scientific Creativity Journal Vol. 3 No. 2 (2025): Student Scientific Creativity Journal
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/sscj-amik.v3i2.5498

Abstract

Nephrons are the smallest functional units in the kidneys that are responsible for filtering blood, regulating fluid balance, and excreting waste through urine. When nephrons are damaged or diseased, kidney function can be significantly impaired. Nephron damage is usually caused by various factors, such as hypertension, diabetes, kidney infections, or certain drug toxicity. In the early stages, nephron damage can cause a decrease in glomerular filtration rate (GFR). As a result, metabolic waste products such as urea and creatinine accumulate in the blood, known as azotemia. Over time, progressive damage to the nephrons can trigger chronic kidney disease (CKD). In more severe cases, when most of the nephrons are no longer functioning, the kidneys lose their ability to maintain the body's homeostasis. This results in electrolyte imbalance, metabolic acidosis, and excess fluid buildup, known as end-stage renal disease (ESRD). At this stage, patients require renal replacement therapy such as dialysis or kidney transplantation to survive. Prevention of nephron damage is very important, including through the management of comorbidities such as diabetes and hypertension, adequate fluid intake, and avoiding exposure to toxic substances that damage the kidneys. Thus, the risk of kidney failure can be minimized.
Peran Asam Nukleat dalam Proses Sintesis Protein: Analisis Mekanisme DNA, RNA, dan Ribosom dalam Regulasi Genetik Amelia Putri Az Azahra; Pramesti Listanto; Khotimah Nur Ramadhani; Tyara Avrilyanti Ghea Indriansyah; Latifa Alya Khairunnisa; Liss Dyah Dewi Arini
Student Scientific Creativity Journal Vol. 3 No. 2 (2025): Student Scientific Creativity Journal
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/sscj-amik.v3i2.5501

Abstract

Nucleic acids play a vital role in the process of protein synthesis, which is the core of genetic regulation in cells. This process involves a complex mechanism of DNA, RNA, and ribosomes working in a coordinated manner. DNA (deoxyribonucleic acid) functions as a genetic blueprint that stores information for protein synthesis. Through the process of transcription, DNA is transcribed into messenger RNA (ribonucleic acid) (mRNA) in the cell nucleus. mRNA carries the genetic code to the cytoplasm, where ribosomes act as translation centers. Ribosomes, together with transfer RNA (tRNA), read the codon sequence on mRNA to determine the sequence of amino acids that will be assembled into polypeptides. This process, called translation, involves complex interactions between mRNA, tRNA, and ribosomes to ensure that the resulting protein is in accordance with genetic instructions. In addition, the role of non-coding RNA, such as microRNA and riboswitches, is also important in regulating gene expression post-transcriptionally. A deep understanding of the mechanisms of DNA, RNA, and ribosomes has opened up great opportunities in biotechnology and medicine, such as gene therapy and RNA-based drug development. Thus, the analysis of the role of nucleic acids becomes an important foundation in the exploration of molecular biology and genetics.
Co-Authors Amelia Putri Az Azahra Elsa Trisna Sari Juwita Ramadhani Octavianingrum Karina Sella Juwitasari Khotimah Nur Ramadhani Latifa Alya Khairunnisa Liss Dyah Dewi Arini Margaretha Alesandria Natasya Weka Nur Aini Fatna Fadilla Pramesti Listanto