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All Journal CHEDS: Journal of Chemistry, Education, and Science Jurnal Sains dan Kesehatan
Olii, Nova Yunita Putri
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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An In Silico Evaluation of the Anti-Wrinkling Potential of Certain Peptides in Relation to the Catalytic Domain of Matrix Metalloproteinase-1 Rahmadani, Agung; Sukemi, Sukemi; Tasya, Indriana; Olii, Nova Yunita Putri; Ridwansyah, Muhammad; Turista, Dora Dayu Rahma; Arifian, Hanggara
Jurnal Sains dan Kesehatan Vol. 7 No. 1 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i1.2518

Abstract

Skin wrinkles are caused by the cleavage of collagen fibers by the major collagenase enzyme matrix metalloproteinase-1 (MMP-1). Peptide-based matrix metalloproteinase-1 inhibitors present a potential new therapeutic strategy to prevent MMP-1-mediated collagenolysis, which is induced by UV-induced MMP-1 overexpression. This in silico study investigated the MMP-1 inhibitory capacity of carefully selected and well-designed hexapeptides. A molecular docking method was employed to screen 14 hexapeptides. The target ligands were observed to interact non-covalently. The LYYYGP peptide sequence was found to form three hydrogen bonds (H-bonds) with amino acid (AA) residues in the catalytic domain of MMP-1. Additionally, hydrophobic interactions between these peptides and the protein were observed at certain sites. The maximum binding affinity was observed for the LYYYGP sequence (binding free energy, ?G = -9.00 kcal/mol). These sequences exhibited binding energies comparable to those of the LSYYGP sequence (-8.48 kcal/mol) and YSGYYP sequence (-8.27 kcal/mol). The YSGYGY sequence demonstrated a lower binding affinity for the target receptor, with ?G = -5.59 kcal/mol. This study indicates that specific peptide sequence components are crucial for forming hydrogen bonds that link proteins to peptides. Further investigation, encompassing chemical synthesis and laboratory experimentation, is requisite to substantiate the efficacy of the two hexapeptides.
LITERATURE REVIEW: INOVASI PEMBELAJARAN KIMIA BERWAWASAN LINGKUNGAN MELALUI PENDEKATAN GREEN CHEMISTRY Aliah, Nur; Wati, Della Syaras; Nurfitriani, Ditalia; Olii, Nova Yunita Putri; Sukemi, Sukemi
CHEDS: Journal of Chemistry, Education, and Science Vol 8, No 2 (2024)
Publisher : Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/cheds.v8i2.10170

Abstract

Green Chemistry merupakan sebuah konsep yang mengangkat permasalahan terkait dampak lingkungan untuk mengurangi penggunaan bahan berbahaya dengan menggunakan bahan yang lebih ramah lingkungan. Pendidikan mempunyai peranan penting sebagai sarana dan prasarana penyaluran green chemistry untuk meningkatkan sikap peduli lingkungan. Metode penelitian yang digunakan adalah Narrative Literature Review (NLR) dengan mencari artikel jurnal melalui database Google Scholar selama 10 tahun terakhir. Hasil studi literatur menunjukkan bahwa pendekatan green chemistry sebagai inovasi bidang pendidikan mempunyai pengaruh besar terhadap peningkatan pengalaman belajar, penguasaan konsep, motivasi dan hasil belajar siswa serta peningkatan kepedulian terhadap lingkungan. Misalnya saja penggunaan bahan alami terbarukan dibandingkan bahan kimia sintetik di laboratorium. Berbagai fasilitas atau bahan ajar digunakan seperti buku atau e-book, e-modul, dan lembar kerja siswa yang menarik.
Co-Authors Arifian, Hanggara Muhammad Ridwansyah Nur Aliah, Nur Nurfitriani, Ditalia Rahmadani, Agung Sukemi Sukemi Tasya, Indriana Turista, Dora Dayu Rahma Wati, Della Syaras