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All Journal Jurnal Plastik Rekonstruksi
Syarif, Akhmad Noviandi
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Civil Engineering, Building, Construction & Architecture Other

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Analyzing The Efficacy and Outcome of Amniotic Membrane in Burn Care: A Systematic Review and Meta-Analysis Putri, Nandita Melati; Wardhana, Aditya; Sandora, Normalina; Syarif, Akhmad Noviandi; Farhana, Nadya; Oklia, Sheila
Jurnal Plastik Rekonstruksi Vol. 12 No. 1 (2025): (2025): Jurnal Plastik Rekonstruksi
Publisher : The Lingkar Studi Bedah Plastik Foundation and is affiliated with the Department of Plastic Surgery, Faculty of Medicine, Universitas Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v12i1.384

Abstract

Introduction: Managing burn injuries is a significant clinical challenge in promoting wound healing and minimizing complications. Advances like amniotic membrane as a biological dressing have been introduced to improve wound healing. This study analyzes the efficacy of amniotic membrane in burn care and its impact on wound healing outcomes.Methods: We conducted a systematic review in Pubmed, Cochrane, and ScienceDirect, using “Amnion”, “Burns”, and “Wound healing” as keywords. The inclusion criteria are studies assessing the application of amniotic membrane on burn wounds. The outcome measures were mean healing time, wound healing rate, incidence of wound infection, dressing renewal frequency, pain score, and LOS.Results: We identified eleven trials (n=971) ranging from the year 1989 to 2023, containing eight RCTs, and three NRCTs. The pooled RR showed statistically significant differences between amniotic membrane group and control group in mean healing time (RR -4.52 [95% CI; -6.93, -2.11]; p=0.0002), wound healing rate (RR 1.60 [95% CI; 1.09, 2.33]; p=0.02), incidence of wound infection (RR 0.48 [95% CI; 0.30, 0.77]; p=0.002), and dressing renewal frequency (RR -1.64 [95% CI; -2.48, -0.79]; p=0.0002).Conclusion: This meta-analysis indicates that amniotic membrane is advantageous as a biological dressing for burn patients.
Co-Authors Aditya Wardhana Farhana, Nadya Oklia, Sheila Putri, Nandita Melati Sandora, Normalina