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Fatma, Nur Aida
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology

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ANALISIS SENYAWA AKTIF DAUN WARU (Hibiscus tiliaceus) SEBAGAI ANTIBAKTERI TERHADAP Escherichia coli Fatma, Nur Aida; Fitria, Fella Nur; Siswanto, Husna Malikatus; Sofa, Natilatus; R., Isma Salsabila; Sa'adah, Rizka Fadilla Naila; Wijaya, M. Achsan Hari; Fitriyah, Fitriyah; Saefi, Muhammad
Binar – Biology Natural Resources Journal Vol 3 No 2 (2025)
Publisher : Prodi Biologi Universitas PGRI Ronggolawe

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55719/binar.v3i2.1557

Abstract

Waru leaves (Hibiscus tiliaceus) are a plant that has bioactive potential with pharmacological benefits. This study aims to analyze the phytochemical content of waru leaves qualitatively, quantitatively, in silico, and their antibacterial activity against Escherichia coli. Qualitative analysis focuses on identifying bioactive compounds such as flavonoids, alkaloids, tannins, saponins, etc. The quantitative approach includes measuring total phenol and flavonoid levels using UV-Vis Spectrophotometry. In silico studies were carried out using the KNApSAcK Family website to identify compound classes, NCBI to obtain SMILES, SWISS ADME to predict pharmacokinetics, and WAY2DRUG PASS Prediction to determine the probability of biological activity. Antibacterial testing uses the diffusion method to determine the MIC and MBC values. The results showed that waru leaves contain various bioactive compounds with total phenolic levels of 30.416 mg GAE/g extract and total flavonoids of -0.476 mg QE/g extract. In silico testing shows that Hibiscus tiliaceus has a unique bioactive compound, namely Hibiscoquinone A, which has potential as a drug candidate with antibacterial activity, lipid peroxidase inhibitor, and ubiquinol-cytochrome-c reductase inhibitor. Antibacterial testing of hibiscus leaf extract against E. coli using the diffusion method obtained MIC values ​​at concentrations of 15% and 30%. However, at these concentrations it did not show MBC values. This research provides scientific evidence regarding the potential of waru leaves as a herbal medicine in treating infectious diseases caused by bacteria.
The PENGUJIAN BAKTERI Escherichia coli PADA PINDANG IKAN LAYANG (Decapterus sp.) DI PASAR CUNGKING, GIRI, BANYUWANGI Fatma, Nur Aida
Binar – Biology Natural Resources Journal Vol 4 No 1 (2025): inpress
Publisher : Prodi Biologi Universitas PGRI Ronggolawe

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55719/binar.v4i1.1647

Abstract

Ikan layang (Decapterus sp.) merupakan komoditas perikanan kedua yang mendominasi di Banyuwangi. Kelimpahan ikan layang dan mudahnya penurunan mutu menyebabkan masyarakat untuk mengembangkan peningkatan mutu ikan layang secara sederhana melalui pemindangan. Produk perikanan mudah mengalami kontaminasi mikroorganisme seperti Escherichia coli. Bakteri E. coli menjadi salah satu parameter pengujian mikrobiologi dalam standar mutu ikan pindang. Pengujian E. coli berdasarkan SNI 2332.1:2015 menggunakan metode Most Probable Number (MPN). Pengujian E. coli terdiri dari preparasi sampel, uji pendugaan coliform, uji pendugaan E. coli, uji penegasan E. coli, uji biokimia yang terdiri dari produksi indol, uji Methtyl Red, uji Voges Proskauer, dan uji sitrat. Hasil penelitian diperoleh keberadaan E. coli pada pindang ikan layang berjumlah 21 MPN/g. Hal ini tidak memenuhi standar baku mutu keamanan pangan tentang ikan pindang berdasarkan SNI 2717-2017 karena batas minimal cemaran E. coli sebesar <3 MPN/g. Keberadaan E. coli berkaitan dengan mutu bahan baku, penanganan bahan ikan, penggunaan air, tempat penyimpanan, lapak penjualan, dan perilaku personal yang kurang memeperhatikan kebersihan. Oleh karena itu, diperlukan peningkatan higienitas, sanitasi, dan menerapkan Good Manufactoring Practices agar diperoleh ikan pindang bermutu baik.
Co-Authors Fitria, Fella Nur Fitriyah Fitriyah Muhammad Saefi R., Isma Salsabila Sa'adah, Rizka Fadilla Naila Siswanto, Husna Malikatus Sofa, Natilatus Wijaya, M. Achsan Hari