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The Impact of Universal Health Coverage Policies on Health Equity Metrics: A Longitudinal Analysis in Indonesia Firman Hadi; Annisa Annisa; Utter Prakesh; Aleisha Wulandari
Community Medicine and Education Journal Vol. 6 No. 1 (2025): Community Medicine and Education Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/cmej.v6i1.696

Abstract

Indonesia has made significant strides towards Universal Health Coverage (UHC) with the implementation of the Jaminan Kesehatan Nasional (JKN) program. However, achieving equitable health outcomes across diverse socioeconomic and geographic groups remains a challenge. This study investigates the longitudinal impact of UHC policies on key health equity metrics in Indonesia. This study employed a longitudinal, quasi-experimental design using a difference-in-differences (DID) approach. Data were collected from a nationally representative sample of Indonesian households from 2014 (pre-JKN expansion) to 2022. The dataset included socioeconomic indicators (wealth quintiles, education, geographic location), health service utilization (antenatal care visits, skilled birth attendance, immunization rates), and health outcomes (under-five mortality rate, stunting prevalence). The DID analysis compared changes in these metrics between groups with varying levels of pre-existing health insurance coverage and socioeconomic status. Multivariable regression models were used to control for confounding factors. The DID analysis showed that UHC expansion was associated with significant improvements in health service utilization, particularly among lower socioeconomic groups. Antenatal care visits increased by an estimated 15% (95% CI: 12-18%) in the lowest wealth quintile compared to a 5% (95% CI: 3-7%) increase in the highest quintile. Skilled birth attendance similarly increased disproportionately among disadvantaged groups. However, while under-five mortality and stunting prevalence decreased overall, significant disparities persisted. The reduction in under-five mortality was smaller in the lowest wealth quintile (10% reduction, 95% CI: 7-13%) compared to the highest (18% reduction, 95% CI: 15-21%). Regression models confirmed that socioeconomic status remained a significant predictor of health outcomes even after controlling for UHC coverage. In conclusion, while Indonesia's UHC policies have improved access to healthcare services, particularly for vulnerable populations, significant health equity gaps remain. Addressing these disparities requires a multi-pronged approach that goes beyond financial protection and includes targeted interventions to address social determinants of health, improve health service quality, and enhance health literacy among disadvantaged communities.
Predicting Meningioma Risk: The Role of Hormone-Related Molecular Markers and Intracellular Signaling Pathways Sari Sulistyoningsih; Miranda Aisah; Utter Prakesh; Bryan Helsey
Sriwijaya Journal of Neurology Vol. 3 No. 1 (2025): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v2i2.185

Abstract

Introduction: Meningiomas are common intracranial tumors with an established association with hormonal factors. This study aimed to comprehensively evaluate the predictive value of hormone-related molecular markers and their associated intracellular signaling pathways in meningioma development. Methods: A retrospective case-control study was conducted, including 200 patients with histologically confirmed meningioma (cases) and 200 age- and gender-matched controls. Tumor tissue and serum samples were analyzed for the expression of estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR), and growth hormone receptor (GHR) using western blot and ELISA, respectively. The activation status of the PI3K/AKT/mTOR and MAPK/ERK signaling pathways was assessed by analyzing the levels of phosphorylated proteins in the pathways. Results: Elevated expression of ER, PR, and GHR was observed in the tumor tissue of meningioma cases compared to controls (p<0.05). Serum levels of ER and PR were also significantly higher in cases. Analysis of signaling pathways revealed increased activation of both PI3K/AKT/mTOR and MAPK/ERK pathways in meningioma cases. Multivariate analysis confirmed that ER and PR expression, both in tumor tissue and serum, were independent predictors of meningioma risk, along with age and female sex. Conclusion: Our findings suggest that ER, PR, and GHR may serve as potential predictive markers for meningioma risk. The involvement of PI3K/AKT/mTOR and MAPK/ERK signaling pathways further underscores the complex interplay between hormonal factors and intracellular signaling in meningioma development. These findings may contribute to improved risk assessment and the development of targeted therapeutic strategies for meningiomas.