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All Journal Molecular and Cellular Biomedical Sciences (MCBS) GHIDZA: Jurnal Gizi dan Kesehatan
Alfadila, Tsania Izza
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Biochemistry, Genetics & Molecular Biology Dentistry Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Sorghum-Soybean Flour Enteral Formula Reduces Blood Glucose, Cholesterol, Triglycerides, LDL, and Increases HDL and Albumin in Hyperglycemic Rats Probosari, Enny; Dewi, Suci Noviya; Alfadila, Tsania Izza; Handayani, Endah Nur; Rizkita, Maura Sania; Candra, Aryu; Ardiaria, Martha; Puruhita, Niken; Murbawani, Etisa Adi
Molecular and Cellular Biomedical Sciences Vol 9, No 1 (2025)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v9i1.507

Abstract

Background: Diabetes mellitus prevalence is rising. Liquid feeding in the form of enteral formulas is needed to meet the nutritional needs of patients who cannot consume orally. The development of enteral formulas based on sorghum-soybean flour for diabetes mellitus patients, which has been nutritionally analyzed and adjusted to the requirements of enteral manufacturing, was selected for further in vivo research. This study evaluated the effect of the sorghum-soybean flour formula on fasting blood glucose (FBG), lipid profile levels, and albumin in hyperglycemic rats.Materials and methods: This was a true experimental study with pre–post-test randomized control design. Wistar rats were divided into four groups: negative control group was normal rats and given standard feed only; positive control group was hyperglycemic rats and given standard feed only; treatment (T)1 and T2 groups were hyperglycemic rats given standard feed along with enteral formula at a dose of 4,41 g/day and 5,51 g/day for 28 days. Blood samples were collected to analyze FBG, albumin, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, and total cholesterol.Results: There were differences in the levels of FBG, albumin, LDL, HDL, triglycerides, and total cholesterol before and after the intervention in groups T1 and T2. Group T1 showed an 8.12% decrease in FBG, while T2 showed a 29.89% decrease. Triglycerides decreased by 29.22% in T1 and 31.85% in T2; cholesterol decreased by 11.41% in T1 and 13.94% in T2. LDL levels decreased by 29.97% in T1 and 38.44% in T2. Albumin levels increased by 47.90% in T1 and 56.67% in T2. HDL levels increased by 23.94% in T1 and in 35.04% in T2.Conclusion: Administration of an enteral formula based on sorghum-soybean flour can reduce FBG, triglycerides, total cholesterol, and LDL levels, and increase albumin and HDL levels in hyperglycemic rats.Keywords: hyperglycemia, enteral formula, albumin levels, fasting blood glucose, HDL, LDL, total cholesterol, triglycerides
Pengembangan Formula Enteral Tinggi Branched-Chain Amino Acid Berbasis Ikan Gabus, Putih Telur Bebek, dan Labu Kuning (GAPULA) Gondosari, Misykat Huda Kesumo Rohmat Putri; Mustikaningrum, Fitriana; Kelimari, Rewinta Putri Denaru; Alfadila, Tsania Izza; Alam, Regita Shalsabillah Dhita; Swastikaningrum, Alifia Divana Ayu
Ghidza: Jurnal Gizi dan Kesehatan Vol. 9 No. 2 (2025): December
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/8yqd8884

Abstract

Liver cirrhosis is a disease of the liver organ that remains a concern in global health. Patients with cirrhosis and malnutrition can experience a higher incidence of complications compared to non-malnourished patients. To prevent the severity of malnutrition due to insufficient nutrient intake through oral food, the use of enteral nutrition high in Branched-Chain Amino Acids (BCAA) can be considered. The objective of this research is to determine the quality of a high BCAA enteral formula based on snakehead fish, duck egg whites, and pumpkin (GAPULA) in terms of nutritional content, osmolality, flow rate, viscosity, and formula acceptability. This research method employs an experimental design using two treatments with variations in the ratio of duck egg whites and snakehead fish in formula 1 at 1:1 and in formula 2 at 1:2. The results of this study indicate that there are differences in viscosity, osmolality, flow rate, and hedonic properties between formula 1 and formula 2. The best viscosity and flow rate were found in formula 2, which had a viscosity of 642.4 cP (P<0.05) and a flow rate of 0.7 cc/second. Meanwhile, the best osmolality was found in formula 1, which had an osmolality of 472 mOsmol/kg. The recommended formula is formula 2, which has a lower viscosity and an osmolality value that is not significantly different from formula 1.
Co-Authors Alam, Regita Shalsabillah Dhita Aryu Candra Dewi, Suci Noviya Enny Probosari Etisa Adi Murbawani Fitriana Mustikaningrum Gondosari, Misykat Huda Kesumo Rohmat Putri Handayani, Endah Nur Kelimari, Rewinta Putri Denaru MARTHA ARDIARIA Niken Puruhita Rizkita, Maura Sania Swastikaningrum, Alifia Divana Ayu