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All Journal International Journal of Public Health Science (IJPHS) Jurnal Penelitian Pendidikan IPA (JPPIPA)
Mambaya, Helvi Desi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Materials Science & Nanotechnology Physics

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Striped catfish oil and turmeric extract reduces inflammation in metabolic syndrome rats Mambaya, Helvi Desi; Muniroh, Muflihatul; Afifah, Diana Nur; Anjani, Gemala; Pramono, Adriyan; Sulchan, Mohammad
International Journal of Public Health Science (IJPHS) Vol 14, No 2: June 2025
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v14i2.24984

Abstract

Metabolic syndrome is a growing global health problem. Long-term treatment for metabolic syndrome causes side effects. Therefore, the use of nutraceuticals could also be considered. This study analyzed the effect of the administration of striped catfish oil and turmeric extract on tumor necrosis factor-α (TNF-α) levels and homeostasis model assessment of insulin resistance (HOMA-IR) in metabolic syndrome rats. Metabolic syndrome was induced in rats by administration of high fat fructose diet (HFFD) containing 3 g pork fat (15%), 2 g duck egg yolk (10%), 15 g standard diet (75%), and 2 ml fructose (1%). Thirty rats were randomized into five groups: C1 (normal control group), C2 (metabolic syndrome control group without treatment), P1 (striped catfish oil at 0.08 ml/200 g BW/day), P2 (turmeric extract at 5.04 mg/kg BW/day), P3 (combination of striped catfish oil at 0.08 ml/200 gBW/day and turmeric extract at 5.04 mg/kg BW/day). There was a significant decrease (p<0.05) in TNF-α levels and HOMA-IR in treatment groups (P1, P2, P3) compared to C2. The P3 group had the lowest TNF-α levels. Treatment groups had the same potential effect in reducing HOMA-IR. Striped catfish oil, turmeric extract, and their combination reduce inflammation and insulin resistance in metabolic syndrome rats.
Striped Catfish Oil and Turmeric Extract-Reduce Inflammation and Insulin Resistance on Metabolic Syndrom: A Review Mambaya, Helvi Desi; Muniroh, Muflihatul; Sulchan, Muhammad; Afifah, Diana Nur
Jurnal Penelitian Pendidikan IPA Vol 10 No SpecialIssue (2024): Science Education, Ecotourism, Health Science
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10iSpecialIssue.7440

Abstract

Metabolic Syndrome is continuing to grow worldwide. Indonesia is no exception. High-calorie diets and physical inactivity trigger several pathways involved in metabolic syndrome. These include inflammation and insulin resistance. Associated with type 2 diabetes mellitus, cardiovascular disease, and death, metabolic syndrome is important. There is therefore a need for early intervention to reduce the complications of this disease. Striped catfish (Pangasius hypophthalmus) is one of the freshwater fish farmed in Indonesia. Turmeric (Curcuma longa Linn.) is also widely used in Indonesian food preparations. This review aims to focus on striped catfish oil and turmeric extract that positively affect inflammation and insulin resistance in the intervention of metabolic syndrome. This review shows that striped catfish oil contains omega-3 fatty acids (EPA and DHA), while turmeric extract contains flavonoids, tannins, and saponins. Based on the results of the review, it is known that bioactive compounds found in catfish oil and turmeric extract can be used as nutraceutical ingredients to intervene in metabolic syndrome.
Co-Authors Adriyan Pramono Anjani, Gemala Diana Nur Afifah, Diana Nur Mohammad Sulchan Muhammad Sulchan Muniroh, Muflihatul