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All Journal Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan
Putri Rizki Fitriani
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Health Professions Nursing Public Health

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Pengaruh Salep Ekstrak Biji Buah Mangga Arumanis (Mangifera Indica L ) Terhadap Penyembuhan Luka Eksisi Secara In Vivo Ifmaily Ifmaily; Ulfa Anggraini; Putri Rizki Fitriani
Jurnal Ventilator Vol. 1 No. 4 (2023): Desember : Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v1i4.830

Abstract

Arumanis mango seeds (Mangifera indica L.) are organic waste, which in previous research contained many secondary metabolite compounds such as flavonoids and had very strong antioxidant activity. Arumanis mango seeds have the potential to heal wounds, including excision wounds. Excision wounds are characterized by the loss of a certain amount of tissue volume that can be filled with wound healing material. The aim of this research was to determine the effect of arumanis mango seed extract ointment on the healing of excision wounds, variations in concentration and histopathological features. The experimental animals were divided into 5 groups, namely the control group (ointment base), the arumanis mango seed extract group with concentrations of 2.5%, 5% and 7.5% and the comparison group (T® ointment). Applying is done 2 times a day for 14 days. The parameters observed were the percentage of wound healing, epithelialization time, and histopathology. Results from the average percentage of healing of excision wounds in the control group (82.4%), concentration 2.5% (85.5%), concentration 5% (90.5%), concentration 7.5% (92.1%) and comparison (95.3%). Results of epithelialization time in the control group (10 days), 2.5% concentration (9 days), 5% concentration group (7 days), 7.5% concentration group (7 days) comparison group (7 days). For histopathology, the scores for epithelialization, collagen fibers and fibroblasts were obtained respectively in the control group (2,1,2), 2.5% concentration (2,2,3), 5% concentration group (2,3,3), concentration group 7.5% (2,3,3) and comparison (3,2,2). The results of the one-way ANOVA test showed that administration of arumanis mango seed extract ointment significantly influenced the parameters of wound healing area and epithelialization time (p<0.05). The conclusion is that arumanis mango seed extract ointment is effective in healing excision wounds. The most effective group for healing excision wounds was the 7.5% concentration group, with good histopathological results.
Pengaruh Salep Ekstrak Kulit Buah Mangga Arumanis ( Mangifera Indica L ) Terhadap Luka Infeksi Pseudomonas Aeruginosa Secara In-Vivo Ifmaily Ifmaily; Sanubari Rela Tobat; Tiara Febria; Putri Rizki Fitriani
Jurnal Ventilator Vol. 2 No. 4 (2024): Desember : Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v2i4.1720

Abstract

Arumanis mango rind is an organic waste that contains secondary metabolites such as flavonoids. Many flavonoids are found in the rind of the arumanis mango, which acts as a very strong antioxidant and has the potential to heal wounds, including infected wounds. This study aims to determine the effect of arumanis mango (Mangifera indica L.) rind extract ointment on healing infected wounds caused by Pseudomonas aeruginosa bacteria, determine the effective concentration for healing infected wounds, and the histopathological decripstions. This research was an experimental study using male white rats which were divided into 5 groups, namely group I (control), group II (Gentamicin), group III (5% concentration), group IV (10% concentration) and group V (15% concentration). The parameters observed were the percentage of healing of infected wounds, epithelialization time, and histopathology. Then the data were analyzed using the ANOVA test followed by Duncan's further test.The results of the study were based on the group order above, from the parameters the average percentage of infected wound healing on 3rd day was 29.73%; 48.84%; 45.95%; 42.81%; 42.33%, on 7th day it was 70.96%; 85.79%; 83.25%; 76.95%; 73.87%, and on the 14th day it was 89.89%; 93.32%; 93.87%; 92.67%; 91.48%. Epithecization time is 9; 6; 7; 8; 9 (day), for histopathology of fibroblast cells with a score of 1; 3; 3; 2; 2; for collagen fibers 1; 3; 3; 3; 3; for re-epithelialization 2; 3; 2; 2; 2; for inflammatory cells 0; 3; 2; 2; 2. The conclusion of the research is that arumanis mango peel extract ointment (Mangifera indica L.) has an influence on the healing process of wounds infected by Pseudomonas aeruginosa bacteria in male white mice, the most effective concentration and the best histopathological descriptions at a concentration of 5%.
Co-Authors Ifmaily Ifmaily Sanubari Rela Tobat Tiara Febria Ulfa Anggraini