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All Journal Medicinus : Jurnal Kedokteran Social, Humanities, and Educational Studies (SHEs): Conference Series
Negara, Puspa
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Education Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences

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COX-2 Expression and Its Prognostic Implications in Uterine Leiomyosarcoma: A Systematic Review and Meta-Analysis Suherman, Levita Dyah Kartika; Sungkarto, Kenny; Ellyamurti, Devanti Octavia; Tarigan, Tiara Namora; Negara, Puspa; Tjahyanto, Teddy; Wijaya, Jeremiah Hilkiah
Medicinus Vol. 14 No. 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i2.9547

Abstract

Background : Uterine leiomyosarcoma (ULMS) is a rare, aggressive malignancy with high recurrence and poor survival, necessitating prognostic biomarkers and therapeutic targets. Cyclooxygenase-2 (COX-2), implicated in tumorigenesis and angiogenesis, remains understudied in ULMS. This systematic review and meta-analysis assessed COX-2’s prognostic role in ULMS. Methods : Following PRISMA guidelines, six studies (n=185) were retrieved from PubMed, EMBASE, and Scopus (2001–2024). Inclusion criteria required ULMS cohorts with COX-2 expression data and survival outcomes. Risk of bias was assessed using QUADAS-2, and evidence certainty via GRADE. A random-effects meta-analysis calculated pooled effect estimates with 95% confidence intervals (CIs), while heterogeneity was evaluated using I² statistics. Result : COX-2 expression correlated moderately with epithelial components (pooled effect: 0.51, 95% CI: 0.26–0.77) and weakly with mesenchymal components (0.26, 95% CI: 0.06–0.45). High heterogeneity (I² = 89.5% and 82.2%) reflected differences in study design, tumor subtypes, and COX-2 measurement thresholds. QUADAS-2 indicated a low risk of bias, and GRADE confirmed high evidence certainty. Stronger epithelial correlations were observed in Asian cohorts, highlighting geographic variability. Conclusions: COX-2 plays a more significant role in epithelial-driven ULMS carcinogenesis. Despite heterogeneity, robust methodologies support these findings. Future studies should standardize COX-2 assessment, expand cohort sizes, and integrate multi-omics approaches to refine prognostic and therapeutic applications.
Literature Review: Potency of Honey Use in Burn Management Negara, Puspa; Tiara, Adelia Hanny
Social, Humanities, and Educational Studies (SHES): Conference Series Vol 7, No 2 (2024): Social, Humanities, and Educational Studies (SHEs): Conference Series
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/shes.v7i2.84902

Abstract

Salah satu jenis cedera yang paling fatal adalah luka bakar yang mengakibatkan tingginya angka kematian dan kecacatan. Banyak prosedur pembedahan, rawat inap yang lama di rumah sakit, rehabilitasi intensif, dan perawatan medis yang mahal semuanya berhubungan dengan luka bakar. Tujuan penelitian ini adalah untuk mengetahui pengaruh madu terhadap proses penyembuhan luka bakar. Metodologi yang digunakan dalam penelitian ini adalah tinjauan pustaka. Populasi sasaran penelitian ini terdiri dari jurnal-jurnal yang mengkhususkan diri pada bidang kesehatan. Perawatan luka bakar dengan madu dapat memberikan hasil yang positif. Madu memiliki pH rendah dan memiliki sifat antibakteri. Di antara bakteri, Staphylococcus aureus adalah yang paling responsif terhadap madu. Kesimpulan penelitian adalah madu dapat digunakan sebagai terapi luka bakar.
Co-Authors Ellyamurti, Devanti Octavia Suherman, Levita Dyah Kartika Sungkarto, Kenny Tarigan, Tiara Namora Tiara, Adelia Hanny Tjahyanto, Teddy Wijaya, Jeremiah Hilkiah