Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Jurnal Anestesi Perioperatif Majalah Anestesia & Critical Care (MACC)
Sibarani, Nicholas Hamonangan
Unknown Affiliation
Education Health Professions Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Perbandingan Bupivakain 0,5% 15 mg dan Fentanil 25 mcg dengan Bupivakain 0,5% 15 mg dan Morfin 100 mcg terhadap Nilai Oksigenasi Serebral pada Pasien yang Menjalani Anestesi Spinal Sibarani, Nicholas Hamonangan; Irina, Sinta; Hamdi, Tasrif
Majalah Anestesia & Critical Care Vol 43 No 1 (2025): Februari
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif (PERDATIN) / The Indonesian Society of Anesthesiology and Intensive Care (INSAIC)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55497/majanestcricar.v43i1.359

Abstract

Latar Belakang: Salah satu teknik pemantauan oksigenasi jaringan yaitu near-infrared spectroscopy (NIRS). Anestesi spinal menurunkan oksigenasi serebral (rSO2) pada penggunaan fentanil dan morfin sebagai adjuvan dari bupivakain. Metode: Penelitian ini merupakan penelitian randomized control trial, dengan tujuan untuk mengetahui perbandingan rSO2 dan hemodinamik pada pasien yang menjalani anestesi spinal. Didapatkan total sampel 36 pasien yang dibagi menjadi 2 kelompok, kelompok yang mendapat bupivakain 0,5% 15 mg ditambah fentanil 25 mcg dan bupivakain 0,5% 15 mg ditambah morfin 100 mcg. Nilai rSO2 dinilai pada sebelum tindakan spinal (T0), 5 menit setelah spinal (T1), dan 30 menit setelah anestesi spinal (T2). Hasil: Rerata rSO2 pada kelompok bupivakain dengan tambahan fentanil berkisar antara 68–72 pada sisi kiri dan kanan. Sementara itu, rerata rSO2 pada kelompok bupivakain dengan tambahan morfin berkisar antara 69–70 pada kedua sisi. Terdapat perbedaan signifikan pada nilai rSO2 pada T1 dan T2 kelompok bupivakain 0,5% 15 mg dengan fentanil 25 mcg dibandingkan dengan kelompok bupivakain 0,5% 15 mg dengan morfin 100 mcg. Simpulan: Pada kelompok dengan tambahan fentanil, terjadi penurunan rSO2 yang tidak signifikan pada T0 dan T1 di kedua sisi kepala, namun penurunan yang signifikan ditemukan pada T2. Sementara itu, pada kelompok dengan tambahan morfin, terjadi penurunan rata-rata rSO2 dari T0 ke T1 dengan nilai penurunan yang tidak signifikan, tetapi penurunan rSO2 yang signifikan ditemukan pada kedua sisi kepala pada T2. Secara keseluruhan, kedua kelompok obat memberikan pengaruh yang serupa terhadap perubahan rSO2.
Hemodynamic Effects of Phenylephrine 100 µg versus Ephedrine 5 mg During Propofol-Induced General Anesthesia: A Randomized Study Sibarani, Nicholas Hamonangan; Lubis, Andriamuri Primaputra; Bangun, Chrismas Gideon; Yunanda, Yuki
Jurnal Anestesi Perioperatif Vol 13, No 3 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15851/jap.v13n3.4454

Abstract

Background: Propofol is widely used for induction of general anesthesia; however, it frequently associated hypotension due to vasodilation and myocardial depression. Vasopressors such as phenylephrine and ephedrine are commonly administered to counteract this effect, but evidence comparing their hemodynamic efficacy during induction remains limited.Methods: This randomized double-blind clinical trial included 80 patients undergoing elective surgery under general anesthesia. Patients were randomly allocated into two groups to receive either phenylephrine 100 µg or ephedrine 5 mg at the time of propofol induction. Demographic characteristics (sex, age, body mass index, and ASA physical status) were recorded. Hemodynamic parameters, including systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate, were measured after premedication and 30 seconds following propofol administration.Results: Baseline characteristics were comparable between the two groups. At 30 seconds after induction, there were no statistically significant differences in systolic blood pressure, diastolic blood pressure, mean arterial pressure, or heart rate between the phenylephrine and ephedrine groups. Both vasopressors effectively maintained hemodynamic stability during propofol induction.Discussion: The findings suggest that phenylephrine and ephedrine have similar hemodynamic profiles when administered during propofol induction. Despite their differing pharmacological mechanisms, both agents were equally effective in preventing early hypotension without significant differences in heart rate or blood pressure responses.Conclusion: Phenylephrine 100 µg and ephedrine 5 mg demonstrated comparable efficacy in maintaining hemodynamic stability during propofol-induced general anesthesia, with no significant difference in their ability to prevent hypotension.
Co-Authors Bangun, Chrismas Gideon Hamdi, Tasrif Irina, Sinta Lubis, Andriamuri Primaputra Yunanda, Yuki