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All Journal JOURNAL LA MEDIHEALTICO Journal of Community Health Provision
Khaera, Ummul
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Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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The Effect of Giving D-Galactose as an Aging Inducer on Body Weight, Glucose Levels and Interleukin-6 Levels in Wistar Rats Gama, Arlina Wiyata; Akib, Rahmawati; Khaera, Ummul
Journal of Community Health Provision Vol. 5 No. 1 (2025): Journal of Community Health Provision
Publisher : PSPP JOURNALS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55885/jchp.v5i1.556

Abstract

Aging is a complex biological process characterized by a decline in physiological functions and an increased susceptibility to chronic diseases. D-galactose, although a naturally occurring monosaccharide, can induce aging when administered in high doses by increasing oxidative stress and inflammation, as indicated by elevated levels of reactive oxygen species (ROS) and interleukin-6 (IL-6). This study aimed to analyze the changes in body weight, blood glucose levels, and IL-6 levels in Wistar rats following D-galactose administration, with the goal of gaining insights into aging mechanisms and exploring potential therapeutic targets for age-related diseases. This was an experimental study using a pre- and post-test design, involving 20 male Wistar rats divided into two groups: a treatment group that received 150 mg/kgBW of D-galactose and a control group that received 0.9% NaCl, both for a duration of six weeks. The study was conducted at the PSPD Research Laboratory, Faculty of Medicine and Health Sciences, UIN Alauddin Makassar, from August to October 2024. Body weight, fasting blood glucose, and serum IL-6 levels were measured weekly using ELISA and a glucometer. Variables analyzed included body weight, glucose levels, and IL-6 levels, with controlled variables such as age, sex, strain, feed, water, and housing conditions. Data were analyzed using an independent t-test with a significance level of p < 0.05. Although changes were observed in all variables, the administration of D-galactose did not result in statistically significant differences in body weight or blood glucose levels between the treatment and control groups. These findings suggest that the aging process induced by D-galactose may involve more complex mechanisms and require further investigation to fully understand its effects and implications for human health.
The Relationship Between Nutritional Status and History of LBW on Child Development Khaera, Ummul; Gama, Arlina Wiyata; Larasati, Iip; Rahman, Abd; Pababbari, Musafir
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2138

Abstract

Optimal child development reflects the future of a nation. Malnutrition and low birth weight (LBW) history are significant determinants impacting children’s development, especially in low-income settings. This study examines the relationship between nutritional status and LBW history with the development of 4-year-old children using the Developmental Pre-Screening Questionnaire (KPSP). The aim is to identify the relationship between nutritional status and LBW history with the developmental outcomes of children aged 4 years. An observational analytic study with a cross-sectional design was conducted in the working area of Jongaya Health Center, Makassar. The study included 56 children, divided into groups based on their nutritional status and LBW history. Data were collected using anthropometric measurements and KPSP. Statistical analysis was performed to determine significant relationships. The results showed a significant relationship between nutritional status and child development (p<0.05). Additionally, children with LBW history showed delayed development compared to those without LBW history (p<0.05). It concludes that nutritional status and LBW history significantly influence the developmental outcomes of 4-year-old children. Early interventions addressing malnutrition and LBW are crucial to ensure optimal development.
Co-Authors Abd Rahman Akib, Rahmawati Gama, Arlina Wiyata Larasati, Iip Pababbari, Musafir