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All Journal Science Midwifery Jurnal Farmasi Kryonaut
Dinayanti, Westi Nur
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Formulation and characterization of bay leaf extract nanophytosomes (Syzgium polyanthum) and affinity study of interaction with alpha glucosidase enzyme as antidiabetic Septianti, Regina Dwi; Jafar, Garnadi; Dinayanti, Westi Nur; Dinata, Deden Indra
Science Midwifery Vol 13 No 1 (2025): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i1.1888

Abstract

Introduction: Diabetes Mellitus is a metabolic syndrome disease in which around 90-95% of all cases of adults aged 20-79 years suffer from type 2 Diabetes Mellitus, with long-term conventional treatment causing side effects of hypoglycemia. Bay leaves which contain quercetin and kaempferol compounds are able to lower blood glucose levels, but have challenges in drug delivery due to easy oxidation and low bioavailability. Therefore, an innovative drug delivery system is needed, such as nanophytosomes, to increase its bioavailability. Objective: This study aims to develop a thin film formula of bay leaf extract nanophytosomes that have antidiabetic affinity with in silico studies and evaluate the physical characteristics of nanophytosomes. Method: in silico using the molecular docking method to evaluate the interaction of active compounds of bay leaves with the alpha glucosidase enzyme. Bay leaf nanophytosomes are formulated using heat homogenization and probe sonicator techniques. Characterization is carried out by measuring particle size, polydispersity index, zeta potential, and particle morphology. Results: The nanophytosome formula of bay leaf extract showed a particle size of <1000 nm, a polydispersity index of <0.5, and a zeta potential of ±25 mV. In silico studies showed that quercetin and kaempferol have a strong affinity for the α-glucosidase enzyme, which plays an important role in inhibiting glucose absorption. Conclusion: Bay leaf extract can be formulated into a phytosome-based nanoparticle delivery system that shows stable physical characteristics, high adsorption efficiency, and potential antidiabetic activity through the interaction of inhibiting the α-glucosidase enzyme.
PENDEKATAN SISTEM PENGHANTARAN NANOPARTIKEL BERBASIS FITOSOM DARI EKSTRAK BAHAN ALAM UNTUK PENGOBATAN PENYAKIT METABOLIK : REVIEW Septianti, Regina Dwi; Dinayanti, Westi Nur; Jafar, Garnadi; Dinata, Deden Indra
Jurnal Farmasi Kryonaut Vol 4 No 2 (2025): JFK
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59969/jfk.v4i2.116

Abstract

Penyakit metabolik, seperti diabetes mellitus, hipertensi, dan obesitas, adalah gangguan kesehatan kronis yang memerlukan penanganan berkelanjutan. Ekstrak bahan alam diketahui memiliki potensi sebagai agen terapeutik untuk penyakit metabolik berkat kandungan senyawa bioaktifnya, seperti flavonoid dan fenolik, yang memiliki aktivitas antioksidan, antiinflamasi, dan penurun kadar gula darah. Namun, kendala pada stabilitas dan bioavailabilitas zat aktif dalam terapi konvensional sering kali membatasi efektivitasnya. Nanoteknologi berbasis fitosom menjadi salah satu inovasi dalam sistem penghantaran obat, yang dapat meningkatkan stabilitas, penetrasi, dan efikasi zat aktif. Artikel ilmiah ini mengkaji literatur dari sumber nasional dan internasional dalam 10 tahun terakhir (2014–2024) yang membahas potensi penggunaan nanopartikel fitosom dari ekstrak bahan alam untuk terapi penyakit metabolik. Hasil kajian menunjukkan bahwa nanopartikel fitosom berukuran kecil memungkinkan peningkatan penetrasi ke dalam sel target, pelepasan bahan aktif secara terkendali, dan perlindungan dari degradasi lingkungan. Selain itu, pengembangan nanopartikel fitosom menawarkan potensi besar dalam meningkatkan efektivitas pengobatan penyakit metabolik melalui formulasi baru dan sistem penghantaran yang lebih terarah. Artikel ini juga mengulas proses sintesis, karakterisasi, mekanisme aksi, dan hasil uji klinis yang relevan. Kesimpulannya, artikel ini memberikan gambaran komprehensif mengenai potensi fitosom sebagai sistem penghantaran zat aktif berbasis nanoteknologi untuk pengobatan penyakit metabolik.
Co-Authors Deden Indra Dinata, Deden Indra Garnadi Jafar, Garnadi Septianti, Regina Dwi