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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health
Jefrizal Wirman
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Computer Science & IT Education Engineering Immunology & microbiology Public Health Social Sciences Other

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The Effect of Alpha Mangostin on The Expression of TGF-β1, SMAD3, Type I Collagen, Proliferation and Migration of Keloid Fibroblasts Asri, Ennesta; Rina Gustia; Indah Indria Sari; Jefrizal Wirman; Yufaz Aidi Mahesa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 1 (2025): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V37.1.2025.41-47

Abstract

Background: Keloid is a process of abnormal collagen thickening during wound healing in skin tissue accompanied by the formation of new blood vessels. Many keloid therapy modalities have been developed but the recurrence rate of those treatment still ranged 1-70%. Herbal plants have been developed for various types of treatment, one of which is for treating keloids. Purpose: The alpha mangostin content in mangosteen peel is known to have antifibrotic properties, further research is needed regarding the administration of alpha mangostin on the process of keloid occurrence. Methods: The investigation was conducted in vitro on phase III keloid fibroblast cells. There were two groups, which divided into the control groups and the treatment groups. The control groups and treatment groups were given alpha mangostin extract in concentrations of 20 μM; the sample of this study was 16. For each group after 24h of the incubation, fibroblast cell proliferation was measured by Microtetrazolium (MTT) assay, fibroblast cell migration was measured by scratch assay, SMAD3 expression was measured after immunocytochemical staining, and type 1 collagen was measured by Enzyme-Linked Immunosorbent Assay (ELISA). The Ethics Committee at the Research Ethics Commission of Faculty of Medicine Andalas University has reviewed this research. Result: Alpha mangostin can reduce the average expression of TGF-β1, SMAD3 expression, type 1 collagen, proliferation, and migration.  . Conclusion: At concentration of 20 μM, alpha mangostin suppressed TGF-β1 expression, SMAD 3, collagen type 1, proliferation, and migration in keloid fibroblast cell.
A Challenge In Establishing The Etiologic Of Toxic Epidermal Necrolysis In Children Jefrizal Wirman; Gardenia Akhyar; Irdawaty Izrul; Qaira Anum
Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Vol. 2 No. 1 (2022): Proceeding of The International Conference of Inovation, Science, Technology, E
Publisher : Program Studi DIII Rekam Medis dan Informasi Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/icistech.v2i1.33

Abstract

Background: Toxic epidermal necrolysis (TEN) is a rare especially in children, acute and potentially lifethreatening. The etiology of the higher incidence of TEN in various pediatric age groups than in adults is unclear, the cause is multifactorial. TEN have known triggering events, including infections (commonly viral or mycoplasma) drugs/herbs, malignancy, vaccines, and idiopathic. Case report: We reported a case TEN of a 5 years old boy. There was a history of fever and red rash on the patient's hands 5 days ago and taken paracetamol, amoxicilin, chlorpeniramin maleat(CTM), and vitamin C, then a red patch and blisters appears 12 hours later. Physical examination: composmentis, temperature 38,80C. Dermatological state: erythemathous macules, vesicles, bulla, erosions, excoriations, crusts on the most of body. Hyperemic conjunctiva, on oral mucosa there were erythematous oedem, erosion, excoriation and reddish-blackish crust, and erosion of the genitalia. Epidermolysis was about ± 40%. Laboratory examination :leucocyte 5300/mm3 with lymphocytosis. Serum urea increases, serum bicarbonate decreases. The patient was treated dexamethasone intra venous and decreased dose with prednisone oral, patient improved and healed on day 13. Discussion: The diagnosis of TEN in patients is made based on history and physical examination. We can establish a typical diagnosis of TEN from clinical symptoms and physical examination, but to find the etiology is sometimes difficult and requires a deep history and other investigations. The etiology in this case cannot be established because of drugs or infection. To find out, it is necessary to do further tests such as serology or PCR
A Challenge In Establishing The Etiologic Of Toxic Epidermal Necrolysis In Children Jefrizal Wirman; Gardenia Akhyar; Irdawaty Izrul; Qaira Anum
Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Vol. 2 No. 1 (2022): Proceeding of The International Conference of Inovation, Science, Technology, E
Publisher : Program Studi DIII Rekam Medis dan Informasi Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/icistech.v2i1.33

Abstract

Background: Toxic epidermal necrolysis (TEN) is a rare especially in children, acute and potentially lifethreatening. The etiology of the higher incidence of TEN in various pediatric age groups than in adults is unclear, the cause is multifactorial. TEN have known triggering events, including infections (commonly viral or mycoplasma) drugs/herbs, malignancy, vaccines, and idiopathic. Case report: We reported a case TEN of a 5 years old boy. There was a history of fever and red rash on the patient's hands 5 days ago and taken paracetamol, amoxicilin, chlorpeniramin maleat(CTM), and vitamin C, then a red patch and blisters appears 12 hours later. Physical examination: composmentis, temperature 38,80C. Dermatological state: erythemathous macules, vesicles, bulla, erosions, excoriations, crusts on the most of body. Hyperemic conjunctiva, on oral mucosa there were erythematous oedem, erosion, excoriation and reddish-blackish crust, and erosion of the genitalia. Epidermolysis was about ± 40%. Laboratory examination :leucocyte 5300/mm3 with lymphocytosis. Serum urea increases, serum bicarbonate decreases. The patient was treated dexamethasone intra venous and decreased dose with prednisone oral, patient improved and healed on day 13. Discussion: The diagnosis of TEN in patients is made based on history and physical examination. We can establish a typical diagnosis of TEN from clinical symptoms and physical examination, but to find the etiology is sometimes difficult and requires a deep history and other investigations. The etiology in this case cannot be established because of drugs or infection. To find out, it is necessary to do further tests such as serology or PCR
Co-Authors Anum, Qaira Asri, Ennesta Gardenia Akhyar Indah Indria Sari Irdawaty Izrul Rina Gustia Yufaz Aidi Mahesa