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All Journal International Journal of Applied and Scientific Research (IJASR) International Journal of Global Sustainable Research
Uwuigbe Mathew
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Religion Humanities Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Social Sciences

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Histological Effect of Ultra Violet (UV) Light on the Brain of Albino Wistar Rats Uwuigbe Mathew; Ohiwerei Wisdom Omogbai; Edebiri Ogbemudia; Ajanwachukwu; Ogbonna Wilson
International Journal of Global Sustainable Research Vol. 2 No. 12 (2024): December 2024
Publisher : MultiTech Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59890/ijgsr.v2i12.2940

Abstract

UV light, or ultraviolet light, is a type of radiation that falls between the visible light and X-ray regions of the electromagnetic spectrum. It is a form of electromagnetic radiation emitted by the sun and artificial sources, such as tanning beds and UV lamps. It has a shorter wavelength than visible light, ranging from 100 to 400 nanometers (nm). It is categorized into three types based on their wavelengths: UVA, UVB, and UVC. The aim of this study is to evaluate the histopathological effect of uv light on the brain of adult Wistar albino rats. In all, fifty (50) adult Albino Wistar rats were used for this study. Group A served as the control and the rats were given distilled water. Animals in the test groups (B, C, D and E) were exposed to 30mins, 1hr, 2hrs and 4hrs of UV lights. After the administration, the rats were put under light chloroform anaesthesia and the brain harvested for histological processing. Short-term exposure (30 min daily) did not cause significant changes, whereas prolonged exposure (1 to 4 hours daily) led to pronounced gliosis, neuronal congestion, and axonal alterations. These findings suggest that chronic UV radiation exposure can have detrimental effects on neural integrity, possibly through oxidative stress, DNA damage, and vascular compromise. The long-term implications of these findings may extend beyond structural damage to include cognitive and behavioral deficits, underscoring the need for further investigations
Evaluation of the Effect of Ginger Zingiber Officinale Extract on Kidney of Albino Rat Administered with Graded Doses of Piroxicam Uwuigbe Mathew; Ohiwerei Wisdom Omogbai; Ajanwachukwu; Ogbonna Wilson; Edebiri Ogbemudia .E; Loveth Ada Adikwu
International Journal of Global Sustainable Research Vol. 3 No. 3 (2025): March 2025
Publisher : MultiTech Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59890/ijgsr.v3i3.2997

Abstract

Ginger or ginger root is the rhizome of the plant Zingiber officinale, commonly consumed as a delicacy, medicine, or spice. It is named after its genus and belongs to the Zingiberaceae family. Ginger is native to southern China and later spread to the Spice Islands, other parts of Asia, West Africa, and the Caribbean. This study aims to evaluate the effects of ginger Zingiber officinale extracts on the kidney when administered alongside graded doses of piroxicam. Fifty albino rats were used, divided into five (5) equal groups (A to E) of ten (10) rats each. Group A served as the control, while Group B received 2.7mg/kg of piroxicam. Group C was administered 400mg/kg of ginger, Group D received 2.7mg/kg of piroxicam and 100mg/kg of ginger, and Group E received 2.7mg/kg of piroxicam along with 400mg/kg of gingerData on weight changes were analyzed using ANOVA, with statistical significance set at P < 0.05. All results were expressed as Mean ± Standard Error of Mean (SEM) and presented in tables for statistical comparison. However, Group B (administered 2.7mg/kg of piroxicam) displayed signs of renal distortion, while Group C (administered 400mg/kg of ginger) showed adipose tissue formation. Groups D and E, which received both piroxicam and ginger at different doses, exhibited normal histological features. Further research is recommended to determine the precise effects of mild, moderate, and high doses of Zingiber officinale (ginger) on kidneys affected by varying levels of piroxicam
Histological Effect of Ultra Violet (UV) Light on the Testis of Albino Wistar Rats Uwuigbe Mathew; Ohiwerei Wisdom Omogbai; Ogbe O Clementina; Ajanwachukwu Ogbonna Wilson; Obeagu E I
International Journal of Applied and Scientific Research Vol. 2 No. 12 (2024): December 2024
Publisher : MultiTech Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

UV light, or ultraviolet light, is a type of radiation that falls between the visible light and X-ray regions of the electromagnetic spectrum. It is a form of electromagnetic radiation emitted by the sun and artificial sources, such as tanning beds and UV lamps. It has a shorter wavelength than visible light, ranging from 100 to 400 nanometers (nm). It is categorized into three types based on their wavelengths: UVA, UVB, and UVC. The aim of this study is to evaluate the histopathological effect of uv light on the testis of male Wistar albino rats. A total of fifty (50) adult Albino Wistar rats of comparable sizes were used for this study. They were divided into four equal groups (A – E) with ten (10) rats each. Group A served as the control and the rats were given distilled water and feed only. In addition to feed and water, Groups B rats were kept under Uv light for 30mins, Group C rats were kept under Uv light for 1hour twice daily, Group D rats were kept under Uv light for 2 hours thrice daily and Group E were kept under Uv light for 4 hours thrice daily. The administration was given daily for 14 days (2 weeks) and the weights of both the test and control animals was monitored before and after administration of Uv light. After the administration, the rats were put under light chloroform anaesthesia and the stomach was obtained. ANOVA was used to analyze the results of the weight and differences was considered significant at p<0.05 level of confidence. All data was expressed in table as mean ± standard deviation (SD). From the results, it was observed that Group B showed mild adenofibroma, Group C exhibited denatured testicular cells, indicating severe damage. Group D had adenocarcinoma and fatty tissue, suggesting potential malignancy and Group E presented fatty tissue. In conclusion, the exposure of testis to uv light cause significant alterations in testis histology
Co-Authors Ajanwachukwu Ajanwachukwu Ogbonna Wilson Edebiri Ogbemudia Edebiri Ogbemudia .E Loveth Ada Adikwu Obeagu E I Ogbe O Clementina Ogbonna Wilson Ohiwerei Wisdom Omogbai