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All Journal Indonesian Journal of Global Health research Journal of Applied Nursing and Health International Journal of Health and Pharmaceutical (IJHP)
Angreni, Frisca
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Morphology Profile and PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Patients Nurprilinda, Marliana; Novelyn, Silphia; Siahaan, Sonya Trinur Veronika; Angreni, Frisca
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6167

Abstract

Lung cancer cases in Indonesia became the second highest with the highest mortality rate in 2022. Various advanced examinations such as histopathology and immunohistochemistry are performed to identify the morphological types of lung cancer. Histopathologically, lung cancer classified into two types are Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC). After histopathological examination, further immunohistochemical testing is required to help classify the subtype and identify therapeutic markers. One of the markers is the expression of Programmed Death Ligand 1 (PD-L1). Patients with this marker can receive anti-PD-L1 immunotherapy according to the specified criteria. This study determined the morphological profile and PD-L1 expression in patients with Non-Small Cell Lung Cancer (NSCLC) at Siloam MRCCC Semanggi Hospital between 2020 and 2022. The method used was descriptive with a retrospective approach by collecting data from the archives of the Anatomical Pathology Laboratory at Siloam MRCCC Semanggi Hospital. The population in this study comprised all patients diagnosed with NSCLC who underwent PD-L1 IHC testing at Siloam MRCCC Semanggi Hospital between 2020 and 2022. Data collection was conducted using a total sampling method, including all individuals who met the predefined inclusion and exclusion criteria. The final sample consisted of 91 patients diagnosed with NSCLC who had undergone PD-L1 IHC examination during the 2020–2022 period. A total of 91 patients including the inclusion and exclusion criteria were included in the data and analyzed. The analysis revealed that the age group 60-69 years accounted for 39.5% of cases, 54.9% of cases were male, 73.6% of cases had an adenocarcinoma morphology, and 54.9% of cases had a negative PD-L1. The incidence of NSCLC patients who underwent PD-L1 IHK examination based on age was dominated by the 60-69 year age group, and most of them were male with the most common diagnosis being adenocarcinoma morphology type and PD-L1 expression with negative values.
Trabeculectomy Surgery in Primary and Secondary Glaucoma: Retrospective Cross-sectional Analysis Christine, Reinne Natali; Tanong, Nicolas Dwiki; Rombe, Claudia Valoryn Iona; Angreni, Frisca
Journal of Applied Nursing and Health Vol. 7 No. 2 (2025): Journal of Applied Nursing and Health
Publisher : Chakra Brahmanda Lentera Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55018/janh.v7i2.333

Abstract

Background: Glaucoma remains a leading cause of permanent blindness worldwide, with elevated intraocular pressure (IOP) as the most modifiable risk factor. When medical therapy fails, trabeculectomy is often the preferred surgical option, though its effectiveness may differ based on the type of glaucoma. Primary glaucoma is typically idiopathic, while secondary glaucoma results from identifiable causes such as trauma, inflammation, or diabetes. Understanding these distinctions is essential for optimizing surgical outcomes and tailoring patient-specific treatment strategies. This study aims to determine whether there is a difference between the reduction in intraocular pressure in primary and secondary glaucoma after undergoing trabeculectomy surgery. Methods: This descriptive cross-sectional study used purposive sampling to select medical records of patients who underwent trabeculectomy at the Christian University of Indonesia Teaching Hospital from July 2021 to June 2022. A total of 30 patients were included. Inclusion criteria were patients diagnosed with either primary or secondary glaucoma who underwent trabeculectomy and had complete pre- and postoperative IOP data. Exclusion criteria included patients with previous glaucoma surgery, incomplete medical records, or less than one month of follow-up. The primary outcome was the percentage reduction in IOP one month postoperatively.. Results: The results showed that the percentage reduction in IOP within 1 month in primary glaucoma was 43.54%, whereas in secondary glaucoma, it was 41.87%. P value > 0.05 in all postoperative IOPs between primary glaucoma and secondary glaucoma. Conclusion: Trabeculectomy is still the first choice to reduce IOP, which has failed pharmacological treatments. However, there was no significant difference between decreased intraocular pressure in patients with primary and secondary glaucoma.
Spastic Lower Paraparesis Due To Multiple Ossification of The Ligamentum Flavum of Fusion and Tuberous Type In The Thoracolumbar Region In A 42-Year-Old Woman Septayudha Suryonegoro, Gregorius; Angreni, Frisca
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.462

Abstract

Ossification of the ligamentum flavum (OLF) is characterized by the replacement of ligamentum flavum tissue with mature laminar bone accompanied by hypertrophy. Although rare, its highest prevalence is reported among East Asian populations, predominantly affecting males under 50 years old, and most commonly found in the lower thoracic region. Clinically, OLF presents as a slowly progressive myelopathy, yet its precise pathogenesis remains unclear. Diagnostic imaging modalities include radiography, computed tomography (CT), and magnetic resonance imaging (MRI). This case report describes a 42-year-old female diagnosed with thoracolumbar OLF based on MRI examination. The patient presented with spastic paraparesis and hypoesthesia from both feet to dermatomes Th10–11 following a history of trauma. Lumbar radiography showed only lumbal spondylosis, while thoracolumbar MRI revealed nodular thickening of the ligamentum flavum from Th6–7 to Th12–L1, resulting in spinal canal stenosis and compression of the spinal cord. Additional degenerative findings included superior endplate degeneration of L4 and multiple intervertebral disc bulging. Neurological deficits indicated myelopathy and radiculopathy due to compression of the lateral corticospinal and spinothalamic tracts. The absence of spinal cord edema on MRI suggested a chronic onset. OLF frequently coexists with vertebral degenerative abnormalities, as observed in this patient. Based on the radiologic characteristics, the lesion represented several morphological types including extended, enlarged, fused, and tuberous forms. Laminectomy performed in this case resulted in gradual neurological recovery. In conclusion, OLF is a rare but important cause of progressive thoracic myelopathy that may lead to irreversible neurological impairment. MRI evaluation plays a crucial role in preoperative assessment of spinal canal stenosis and spinal cord compression.
Co-Authors Novelyn, Silphia Nurprilinda, Marliana Reinne Natali Christine, Reinne Natali Rombe, Claudia Valoryn Iona Septayudha Suryonegoro, Gregorius Siahaan, Sonya Trinur Veronika Tanong, Nicolas Dwiki