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All Journal Indonesian Journal of Dental Medicine
Putri, Salsabila Fitriana
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Dentistry

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White sponge nevus as a hereditary disease: A brief narrative review Mahdani, Fatma Yasmin; Puspasari, Karlina; Manuaba, Ida Bagus Pramana Putra; Putri, Salsabila Fitriana; Ayunnisa, Naqiya; Ernawati, Diah Savitri; Hendarti, Hening Tuti
Indonesian Journal of Dental Medicine Vol. 8 No. 1 (2025): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v8i1.2025.49-52

Abstract

Background: White sponge nevus (WSN) is an autosomal dominant hereditary genetic disorder characterized by thickened keratin in the oral mucosa that appears folded, wavy, spongy, thick, and rough. WSN do not have the potential to become malignant, but an accurate diagnosis is still needed to prevent unnecessary treatment and reduce potential remissions and exacerbations due to infection. Purpose: to provide a detailed description of white sponge nevus as a hereditary disease by means of narrative review. Review: A literature search using ScienceDirect and PubMed yielded results between 2012 and 2024. The keywords of the search strategy were “hereditary disease” and “white sponge nevus” or “Cannon’s disease” or “white folded gingivostomatitis” or “leukokeratosis.”. White sponge nevus (WSN) was first discovered by Hyde in 1909 and usually occurs in children and people under 20 years old. The main etiology of WSN is an autosomal dominant hereditary genetic disorder; KRT4 and KRT13 are specific keratin encoders that cause WSN, and there are predisposing factors such as bacterial infection, smoking, and alcohol consumption. Conclusion: In determining the diagnosis of WSN, it is necessary to carry out blood tests, subjective examinations, objective examinations, and supporting examinations in the form of exfoliative cytology and biopsies. As well as the need for comprehensive treatment, even though the prognosis of this disorder is good.
Co-Authors Ayunnisa, Naqiya Diah Savitri Ernawati Fatma Yasmin Mahdani Hening Tuti Hendarti Manuaba, Ida Bagus Pramana Putra Puspasari, Karlina