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All Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Buana Farma Jurnal Komprehenshif
Ningsih, Ira Wahyu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Immunology & microbiology Medicine & Pharmacology Social Sciences

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EFEK ANTIMIKROBA EKSTRAK Arcangelisia flava, Curcuma longa, Curcuma zanthorrhiza TERHADAP Bacillus DAN Pseudomonas PENYEBAB DIARE Hujjastusnani, Noor; Amin, Astuti muh.; Nirmalasari, Ridha; Awaluddin, Annisa Maharani; Latifah, Nadia Dwi Nur; Riana, Rifa; Nisa, Khairun`; Ningsih, Ira Wahyu; Anisa, Nor
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1256

Abstract

Diarrhea is a major health issue often caused by Bacillus sp. and Pseudomonas aeruginosa. This study aims to evaluate the antibacterial activity of a combination of Arcangelisia flava, Curcuma longa, and Curcuma zanthorrhiza extracts against these bacteria. The research was conducted in vitro using a Completely Randomized Design (CRD) with extract concentrations of 30%, 50%, 75%, and 100%, along with positive and negative controls. Antibacterial tests were carried out using the disk diffusion method to measure the inhibition zones after 24, 48, and 72 hours of incubation. The results showed the highest inhibition zones at 100% concentration, reaching 1.38 mm for Bacillus sp. and 1.33 mm for Pseudomonas aeruginosa after 72 hours. This antibacterial activity is supported by active compounds such as flavonoids, alkaloids, and curcumin. In conclusion the combination of these extracts effectively inhibits diarrhea-causing bacteria and has potential as a safe herbal alternative to address antibiotic resistance.
SEJARAH DAN BENTUK WHITE COLLAR CRIME Rahman, Anisah; Ningsih, Ira Wahyu
Komprehensif Vol 1 No 2 (2023)
Publisher : CV Edu Tech Jaya

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Abstract

Penelitian ini secara khusus mengkaji tentang kasus kejahatan kerah putih di Indonesia. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana kasus kejahatan yang berjalan di Indonesia khususnya pada kejahatan keuangan atau yang disebut White collar crime. Penelitian kepustakaan. Penelitian dokumenter adalah penelitian dalam penelitian ini yang mengumpulkan informasi dari lapangan (perpustakaan) dan mengkaji sumber data non-manusia. Hasil pembahasan ini menunjukkan bahwa terdapat beberapa kasus flexing atau pamer harta kekayaan di media sosial yang berujung pada pengungkapan kasus korupsi
ANTIFUNGAL EFFECTIVENESS OF BAJAKAH ROOT EXTRACT (Uncaria acida) AGAINST THE ACTIVITY OF Malassezia furfur, THE CAUSATIVE AGENT OF SEBORRHEIC DERMATITIS IN MICE Ningsih, Ira Wahyu; Rohmadi, Mukhlis; Indahsari, Lilin Ika Nur
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 12 No. 2 (2026): Biolink February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v12i2.16935

Abstract

Seborrheic dermatitis is a chronic skin disorder associated with colonization by Malassezia furfur and is commonly treated with topical antifungal agents and corticosteroids, which may cause adverse effects when used long term. Therefore, safer and more sustainable alternative therapies derived from natural products are needed. One such candidate is bajakah root (Uncaria acida), which is known to contain flavonoids, alkaloids, tannins, terpenoids, and saponins with potential antifungal activity. This study employed a true experimental posttest-only design involving 24 male BALB/c mice induced with Malassezia furfur and divided into a negative control group (distilled water), a positive control group (ketoconazole), and treatment groups receiving Uncaria acida extract at concentrations of 25%, 50%, 75%, and 100%. The research stages included extr act preparation using ethanol maceration, ointment formulation, fungal infection induction, and clinical evaluation. Phytochemical analysis confirmed a total flavonoid content of 28.5 mg QE/g. The results demonstrated significant differences across all clinical parameters (p < 0.05), with the 75% extract concentration providing the most optimal clinical improvement. These findings indicate that Uncaria acida extract has strong potential for development as a topical herbal therapeutic candidate and provides a foundation for further studies focusing on formulation optimization and clinical trials.
Co-Authors Astuti Muh. Amin Awaluddin, Annisa Maharani Hery Widijanto Hujjastusnani, Noor Indahsari, Lilin Ika Nur Latifah, Nadia Dwi Nur Mukhlis Rohmadi Nirmalasari, Ridha Nisa, Khairun` Rahman, Anisah Riana, Rifa