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All Journal JURNAL FARMASIMED (JFM) Medistra Medical Journal (MMJ)
Andy Febriady
Institut Kesehatan Medistra Lubuk Pakam
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Optimization of the Preventive Potential of Andaliman (Zanthoxylum acanthopodium DC) as a Natural Biofilter Against Cigarette SmokeExposure Through TNF-α Expression Novidawati Boru Situmorang; Andy Febriady
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/d1tsbq73

Abstract

Background: Indonesia ranks third in the world for the highest smoking prevalence after China and India. Smokers often smoke both indoors and outdoors, exposing others to harmful cigarette smoke. Cigarette smoke can trigger oxidative stress, which induces the release of pro-inflammatory cytokines such as Tumor Necrosis Factor (TNF-α). Objective: This study aimed to analyze the optimization of andaliman (Zanthoxylum acanthopodium DC) as a natural biofilter against cigarette smoke exposure through TNF-α expression as a potential preventive measure. Methods: An experimental method was used by measuring TNF-α expression in serum isolated from mice blood using the Enzyme-Linked Immunosorbent Assay (ELISA) technique. Results: TNF-α levels measured by ELISA showed that andaliman extract at doses of 50–400 mg/kg body weight significantly reduced TNF-α levels in mice exposed to cigarette smoke compared to the negative control group (p < 0.05). This reduction is likely related to the presence of flavonoids and alkaloids in andaliman, which act as antioxidants and immunomodulators that inhibit inflammatory pathways triggered by oxidative stress from cigarette smoke. With its anti-inflammatory potential, andaliman can be developed as an eco-friendly natural biofilter to prevent the harmful effects of cigarette smoke, although further studies are needed regarding its optimal dosage and long-term safety. Conclusion: Andaliman extract (Zanthoxylum acanthopodium DC) effectively reduced TNF-α levels in mice exposed to cigarette smoke, demonstrating anti-inflammatory potential as a natural biofilter. Its flavonoid and alkaloid content act as antioxidants and immunomodulators that suppress inflammatory pathways induced by cigarette smoke toxins. Andaliman shows promise as an environmentally friendly natural preventive agent to mitigate the negative impacts of cigarette smoke exposure.
Development of Molecularly Imprinted Polymer Materials as Selective Recognition Elements for Electrochemical Meropenem Sensors Herlina Herlina; Ahmad Hafizullah Ritonga; Andy Febriady; Asvia Rahayu; Naomi Geraldin Sinaga
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/j884sv81

Abstract

The rising prevalence of bacterial resistance to carbapenem antibiotics, particularly meropenem, highlights the urgent need for rapid, selective, and efficient detection methods. This study reports the synthesis of molecularly imprinted polymers (MIPs) based on methyl methacrylate (MMA) as selective recognition elements for electrochemical meropenem sensors. Bulk polymerization was employed using MMA as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the crosslinker, dimethyl sulfoxide (DMSO) as the porogen, and benzoyl peroxide (BPO) as the initiator. Both non-imprinted polymers (NIPs) and molecularly imprinted polymers (MIPs) were prepared, followed by template extraction through sequential washing with acetonitrile, methanol–acetic acid, and methanol–deionized water to generate specific recognition cavities. Characterization using Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) confirmed the success of molecular imprinting, as evidenced by the disappearance of characteristic meropenem bands and the formation of porous cavities in the MIP. Adsorption studies revealed that the MIP exhibited a higher adsorption capacity (8.9940 mg/g) compared to the NIP (3.9904 mg/g), yielding an imprinting factor (IF) of 2.25. Selectivity testing against the competing analyte amoxicillin produced a selectivity coefficient (α) of 1.06, indicating preferential binding toward meropenem despite modest discrimination. These results demonstrate that MMA–EGDMA-based MIPs possess promising potential as selective recognition elements for electrochemical meropenem sensors. The developed material not only contributes to the advancement of functional polymer research but also offers practical opportunities for real-time monitoring of antibiotic levels in clinical and environmental samples.
Utilization Of Butterfly Pea Flowers (Clioria ternate L.) In Gram Staining Of Staphylococcus aureus and Escherichia coli Bacteria DIAN HASTARI NINGRUM; Herlina Herlina; Visensius Krisdianilo; Andy Febriady
Medistra Medical Journal (MMJ) Vol 2 No 1 (2024): Medistra Medical Journal (MMJ)
Publisher : Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/mmj.v2i1.2377

Abstract

Introduction : Butterfly pea flower (Clitoria ternatea L.) is one of the most commonly found plants.  Butterfly pea flowers contain anthocyanins which are abundant in the flowers and play a role in giving red, violet-blue color to the flowers. Anthocyanins are the main molecules of plant colorants. The potential of anthocyanins in butterfly pea flowers can be used as a natural coloring reagent. Objective : The purpose of this study was to determine whether telang flower extract can be used as a substitute for gentian violet in Gram staining. Method : The research method used is experimental. Result : The results of Gram staining research using original pH butterfly pea flower extract at concentrations of 1:10, 2:10, 3:10, 4:10, and pH 5 butterfly pea flower extract at concentrations of 1:10, 2:10, 3:10, 4:10, 5:10 on Staphylococcus aureus bacteria showed poor bacterial staining results because the bacteria were not purple while the original pH butterfly pea flower extract at a concentration of 5:10 showed good staining results because the bacteria were purple. While in Escherichia coli bacteria, butterfly pea flower extract shows good staining results because the bacteria are red. Conclusion : Data analysis using the Kruskal Wallis test obtained Asymp. Sig (0.000) <0.05, it can be concluded that there is a significant difference in Gram staining using gentian violet and telang flower extract with variations in pH and composition as a substitute for gentian violet.
Co-Authors Asvia Rahayu DIAN HASTARI NINGRUM Herlina H Naomi Geraldin Sinaga Novidawati Boru Situmorang Visensius Krisdianilo