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All Journal Journal of Pharmaceutical and Health Research Journal of Pharmaceutical and Sciences.
Misworo, Misworo
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Analisa Fitokimia dan Aktivitas Antioksidan Sirup Herbal Ekstrak Buah Labu (Curcubita Moschata) dan Rimpang Kunyit (Curcuma Domestica) dengan Metode DPPH Kurniasih, Khamdiyah Indah; Fauziah, Fauziah; Misworo, Misworo; Prismadito, Hansen
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6189

Abstract

Pumpkin is one of the natural ingredients with antioxidant properties, and it helps reduce symptoms of diabetes, hypertension, tumors, cholesterol, antibacterial, anthelmintic, and anti-inflammatory effects. The polyphenol and flavonoid contents in pumpkin are 97.4 mgGAE/gram and 28.6 mgQE/gram, respectively, with high antioxidant activity against DPPH radicals at 0.065 ± 0.010 mol TE/gram. Turmeric rhizome is also a plant with high antioxidant activity. Turmeric rhizome contains curcumin as the main active compound, with a content of 7.798%. The ethanol extract of turmeric rhizome exhibits antioxidant activity with an IC50 value of 41.95 µg/mL (DPPH). Studies on the composition and benefits of pumpkin and turmeric rhizome have been conducted. However, so far, there has been no standardization of the simplicia and extracts of these two plants from Central Java. The herbal syrup combining pumpkin and turmeric extracts is an herbal product that has not been scientifically proven regarding its metabolite compounds and antioxidant activity, which play a role in addressing various degenerative diseases. Therefore, standardization of the simplicia and verification of the phytochemical metabolites and antioxidant content are necessary. This study was conducted by comparing the IC50 values of three syrup formulas: turmeric rhizome syrup (F1), pumpkin syrup (F2), and a mixture of pumpkin and turmeric rhizome syrup (F3). The results showed that Formula 1 (F1) had the lowest IC50 value of 17.366 µg/mL, indicating the highest antioxidant potential, followed by F3 with an IC50 of 47.862 µg/mL, and F2 with the lowest antioxidant activity, with an IC50 value of 288.545 µg/mL.
Tingkat Penggunaan Antibiotik dan Pola Peresepannya Pada Infeksi Saluran Pernapasan (ICD-10: J00-J99) di Indonesia Selama Pandemi COVID-19 Misworo, Misworo; Kusuma, Ikhwan Yuda; Kurniasih, Khamdiyah Indah; Nurkholis, Fiqih; Fauziah , Fauziah
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.849

Abstract

Introduction: Respiratory tract infections (RTIs) contribute substantially to global antibiotic consumption, raising concerns about antimicrobial resistance (AMR). This study aimed to analyze antibiotic prescribing patterns for respiratory disorders in an Indonesian teaching hospital during the COVID-19 pandemic. Methods: This retrospective, cross-sectional study examined systemic antibiotic prescriptions based on the Anatomical Therapeutic Classification (ATC: J01) for respiratory diseases (ICD-10: J00-J99) at Cilacap Government Teaching Hospital between January and December 2021. Data were extracted from electronic medical records (e-MR), including patient demographics (i.e. age and sex), ICD codes and name of antibiotics. We analyzed WHO AWaRe classifications, administration routes, and seasonal patterns based on patient’s entry and antibiotic use. Results: The study included 2,395 patients with antibiotic prescriptions for respiratory disorders. The Watch group antibiotics accounted for 85.6% of prescriptions, with the highest use among adults (86.2%). Parenteral administration (71.5%) was more common than oral administration (28.5%). Pneumonia (38.2%) and chronic obstructive pulmonary disease (27%) were the most common indications. Antibiotic use peaked in December (n=529) and was lowest in July (n=84). Ceftriaxone (n=838), azithromycin (n=270), cefixime (n=262), levofloxacin (n=216), and meropenem (n=56) were among the top prescribed antibiotics. Conclusion: The study highlights the predominant use of broad-spectrum and parenteral antibiotics for respiratory disorders, raising concerns about AMR. Factors such as seasonality, disease patterns, and diagnostic challenges may have influenced prescribing practices. Implementing antimicrobial stewardship programs, promoting evidence-based guidelines, and addressing modifiable risk factors are crucial to combat AMR and optimize patient outcomes during and beyond the COVID-19 pandemic.
Co-Authors Fauziah , Fauziah Fauziah Fauziah Ikhwan Yuda Kusuma Kurniasih, Khamdiyah Indah Nurkholis, Fiqih Prismadito, Hansen